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11.发明公开NOUVEAUX DERIVES TRICYCLIQUES DE DIHYDRO-QUINOLEINES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开新DIHYDROISOCHINOLINTRIZYKLISCHE衍生物，其制造方法和药物制剂
公开(公告)号：EP1389210A1
公开(公告)日：2004-02-18
申请号：EP02740805.3
申请日：2002-05-22
发明人： HUSSON, Henri-Philippe , GIORGI-RENAULT, Sylviane , DESBENE, Stéphanie , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D491/14 , C07D497/14 , C07D491/04
CPC分类号： C07D491/04 , C07D491/14 , C07D497/14
摘要： The invention concerns a compound of formula (I), wherein (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv), (v), (vi) and (vii). The inventive compounds, besides their novelty, exhibit very interesting antitumour properties.
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12.发明授权DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权9 AMINOPODOPHYLLOTOXINDERIVATE，其制备方法和药物组合物含有这些衍生物
公开(公告)号：EP1664055B9
公开(公告)日：2007-10-10
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
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13.发明公开DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权9 AMINOPODOPHYLLOTOXINDERIVATE，其制备方法和药物组合物含有这些衍生物
公开(公告)号：EP1664055A1
公开(公告)日：2006-06-07
申请号：EP04787274.2
申请日：2004-09-01
发明人： MONNERET, Claude , DAUZONNE, Daniel , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN-NH and N-R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
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14.发明公开DERIVES DE PYRROLO[3,4-C]CARBAZOLE ET DE PYRIDO[2,3-B]PYRROLO[3,4-E]INDOLE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开PYRROLO¬3,4-C咔唑和PYRIDO¬2,3-BPYRROLO¬3,4E-吲哚衍生物，生产和药物制剂的方法
公开(公告)号：EP1554277A1
公开(公告)日：2005-07-20
申请号：EP03778389.1
申请日：2003-10-14
发明人： PRUDHOMME, Michelle , HUGON, Bernadette , ANIZON, Fabrice , HICKMAN, John , PIERRE, Alain , GOLSTEYN, Roy , RENARD, Pierre , PFEIFFER, Bruno
IPC分类号： C07D471/22 , C07D487/14 , A61K31/437 , A61K31/407 , A61P35/00
CPC分类号： C07D487/14
摘要： The invention concerns compounds of formula (I), wherein: Z represents a group of formula U-V such as defined in the description; W1 represents, with the carbon atoms to which it is bound, a phenyl group or a pyridinyl group; W2 is such as defined in the description; X1, X2 represent each a hydrogen atom, a hydroxy, alkoxy, mercapto or alkylthio group; Y1, Y2 represent each a hydrogen atom, or X1 and Y1, X2 and Y2 represent each a hydrogen atom, a hydroxy, a linear or branched C1-C6 alkoxy, mercapto, and linear or branched C1-C6 alkythio group; R1 is such as defined in the description; Q represents an oxygen atom or a NR2 group such as defined in the description.
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15.发明公开DERIVES DE PYRIDO-PYRIDO-PYRROLO PYRROLO-INDOLE ET PYRIDO-PYRROLO PYRROLO CARBAZOLE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开PYRIDOPYRIDOPYRROLOPYRROLOINDOL- AND PYRIDOPYRROLOPYRROLOCARBAZOLDERIVATE，其制造方法和方法衍生物技术含有的药物组合物
公开(公告)号：EP1409486A1
公开(公告)日：2004-04-21
申请号：EP02767534.7
申请日：2002-06-28
发明人： PRUDHOMME, Michelle , MARMINON, Christelle , ROUTIER, Sylvain , COUDERT, Gérard , MEROUR, Jean-Yves , HICKMAN, John , PIERRE, Alain , RENARD, Pierre , PFEIFFER, Bruno
IPC分类号： C07D471/22 , C07D498/22 , A61K31/44
CPC分类号： C07H15/252
摘要： Compounds of formula (I) wherein: WI and W2 represent, with the carbon atoms to which they are bound, a phenyl group or a pyridinyl group, and at least one of the groups W1 or W2 represent a pyridinyl group; R1 and R2 each represent a group of formula U-V as defined in the description, X and X1 each represent a hydrogen atom, a hydroxy, alkoxy, mercapto or alkylthio group; Y and Y1 each represent a hydrogen atom; or X and Y, X1 and Y1 represent, together with the carbon atom that they include, a carbonyl or thiocarbonyl group; R4 and R5 are as defined in the description; Q1, Q2 represent a hydrogen atom, or Q1 and Q2, together with the carbon atoms that they include, form an aromatic link. The inventive compounds are used in medicaments.
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16.发明公开
公开(公告)号：EP1910377A2
公开(公告)日：2008-04-16
申请号：EP06794288.8
申请日：2006-08-04
IPC分类号： C07D491/22 , C07D471/14 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/14
摘要： Compounds of formula (I), wherein R1, R2, R3, R4, R5, R80, R90, R81, R91, AIk and G are such as defined in the description, can be used for drugs.
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17.发明公开NOUVEAUX DERIVES DE 1,4 BENZODIOXINO 2,3-e ISOINDOLE SUBSTITUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权取代的[1,4]苯并二恶英并[2,3-E]异吲哚衍生物，PROCESS FOR它们的生产和药物组合物
公开(公告)号：EP1587810A1
公开(公告)日：2005-10-26
申请号：EP03809363.9
申请日：2003-10-17
发明人： COUDERT, Gérard , AYERBE, Nathalie , LEPIFRE, Franck , ROUTIER, Sylvain , CAIGNARD, Daniel-Henri , RENARD, Pierre , HICKMAN, John , PIERRE, Alain , LEONCE, Stéphane
IPC分类号： C07D498/14 , C07D498/22 , C07D491/14 , C07D487/04 , A61P35/00 , A61K31/5365
CPC分类号： C07D471/14 , C07D487/04 , C07D491/14
摘要： The invention concerns compounds of formula (I), wherein: A is such as described in the description; Y represents a group selected among an oxygen atom or a methylene group; R2 represents a hydrogen atom, in which case: R3 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or SO2CF3, or R2 and R3 form a bond; R1 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or a linear or branched C1-C6 alkylene chain; Z1 and Z2 represent each a hydrogen atom or Z1 and Z2 form together, with the carbon atoms bearing them, a phenyl group. The invention is useful for preparing medicines.
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18.发明公开
公开(公告)号：EP1292597A1
公开(公告)日：2003-03-19
申请号：EP01947525.0
申请日：2001-06-19
发明人： MONNERET, Claude , BERTOUNESQUE, Emmanuel , MERESSE, Philippe , ATASSI, Ghanem , PIERRE, Alain , HICKMAN, John , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/365 , A61P35/00
CPC分类号： C07D493/04 , Y02P20/55
摘要： A compound selected from these of formula (I):wherein:R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono,R2 represents oxygen or sulphur,R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl,X represents linear or branched (C1-C6)alkylene,R4 represents a group selected from amino optionally substituted by one or two groups, -N(R3)-X1-OR5 wherein R3, X1 and R5 are as defined in the description, -N(R3)-X1-NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, -O-X1-OR5 wherein R5 and X1 are as defined in the description, and -O-X1-NR6R7 wherein R6, R7 and X1 are as defined in the description,its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.
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19.发明授权NOUVEAUX DERIVES DE L'ACRONYCINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权ACRONYCINDERIVATE，其制造方法SAME和药物制剂
公开(公告)号：EP1042326B1
公开(公告)日：2002-06-19
申请号：EP98962511.6
申请日：1998-12-18
发明人： KOCH, Michel , TILLEQUIN, François , MICHEL, Sylvie , ATASSI, Ghanem , PIERRE, Alain , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D491/052 , A61K31/44 , C07D491/14 , C07D498/14
CPC分类号： C07D491/04 , C07D491/14
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