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11.发明授权BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权杂环β-氨基化合物作为用于治疗或二肽基肽酶抑制剂 预防糖尿病
公开(公告)号：EP1490335B1
公开(公告)日：2007-09-19
申请号：EP03745557.3
申请日：2003-03-21
申请人： Merck & Co., Inc.
IPC分类号： C07D487/04 , A61K31/495 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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12.发明授权PHENYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权苯丙氨酸衍生物作为糖尿病的治疗或预防二肽基肽酶抑制剂
公开(公告)号：EP1562925B1
公开(公告)日：2007-01-03
申请号：EP03783112.0
申请日：2003-11-03
申请人： Merck & Co., Inc.
发明人： COLANDREA, Vincent, J. , EDMONDSON, Scott, D. , MATHVINK, Robert, J. , MASTRACCHIO, Anthony , WEBER, Ann, E. , XU, Jinyou
IPC分类号： C07D295/18 , C07D207/10 , C07D403/10 , C07D401/10 , C07D413/10 , C07D417/10 , C07D403/12 , C07D471/04 , C07D403/06 , C07D487/04 , C07D205/04 , C07D211/38 , C07D213/64 , A61K31/40 , A61K31/395 , A61K31/445 , A61P3/10
CPC分类号： C07D205/04 , C07D207/10 , C07D211/38 , C07D213/64 , C07D295/185 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07D487/04
摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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13.发明授权BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权β-氨基四氢（1,2-A）吡嗪和-TETRAHYDROTRIAZOLO（4,3-A）吡嗪ALS二肽基肽酶抑制剂对于糖尿病的治疗或预防
公开(公告)号：EP1412357B1
公开(公告)日：2006-03-22
申请号：EP02749813.8
申请日：2002-07-05
申请人： Merck & Co., Inc.
发明人： EDMONDSON, Scott, D. , FISHER, Michael, H. , KIM, Dooseop , MACCOSS, Malcolm , PARMEE, Emma, R. , WEBER, Ann, E. , XU, Jinyou
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/10
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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14.发明公开3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 审中-公开3-氨基-4-PHENYLBUTANSÄUREDERIVATEALS抑制剂的二肽为糖尿病治疗或预防
公开(公告)号：EP1592689A2
公开(公告)日：2005-11-09
申请号：EP04705717.9
申请日：2004-01-27
申请人： Merck & Co., Inc.
发明人： ASHTON, Wallace, T. , CALDWELL, Charles, G. , DUFFY, Joseph, L. , MATHVINK, Robert, J. , WANG, Liping , WEBER, Ann, E.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4375 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/53 , A61P3/10
CPC分类号： C07D471/04 , C07D217/06 , C07D217/26
摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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15.发明公开3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 审中-公开3-氨基-4-苯基丁酸衍生物作为二磷酸二肽酶抑制剂用于治疗或预防糖尿病
公开(公告)号：EP1589969A2
公开(公告)日：2005-11-02
申请号：EP04701770.2
申请日：2004-01-13
申请人： Merck & Co. Inc.
发明人： ASHTON, Wallace, T. , CALDWELL, Charles, G. , MATHVINK, Robert, J. , OK, Hyun, O. , REIGLE, Leah, Bitalac , WEBER, Ann, E.
IPC分类号： A61K31/4365 , C07D513/04
CPC分类号： C07D498/04 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶抑制剂（'DP-IV抑制剂'）的3-氨基-4-苯基丁酸衍生物，其可用于治疗或预防其中二肽基肽酶 - IV酶参与，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗其中涉及二肽基肽酶-IV酶的疾病中的用途。
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16.发明公开BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权β-氨基四氢吡啶甲酸（1,2-A）吡咯烷酮（4,3-A）吡嗪ALS DIPEPTIDYL PEPTIDASE INHIBITOREN ZUR BEHANDLUNG ODER PREVENTION VON DIABETES
公开(公告)号：EP1412357A1
公开(公告)日：2004-04-28
申请号：EP02749813.8
申请日：2002-07-05
申请人： Merck & Co., Inc.
发明人： EDMONDSON, Scott, D. , FISHER, Michael, H. , KIM, Dooseop , MACCOSS, Malcolm , PARMEE, Emma, R. , WEBER, Ann, E. , XU, Jinyou
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/10
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及包含二肽基肽酶-IV酶抑制剂（“DP-IV抑制剂”）的化合物的药物组合物，以及这些组合物在治疗或预防二肽基肽酶-IV酶是 涉及，如糖尿病，特别是2型糖尿病。
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公开(公告)号：EP1406622A2
公开(公告)日：2004-04-14
申请号：EP02737543.5
申请日：2002-06-19
申请人： Merck & Co., Inc.
发明人： BROCKUNIER, Linda , PARMEE, Emma , WEBER, Ann, E.
IPC分类号： A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5375 , C07D211/32 , C07D241/04 , C07D265/30 , C07D295/185 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/10 , C07D409/06 , C07D417/04
CPC分类号： C07D275/06 , C07D209/14 , C07D213/36 , C07D217/22 , C07D239/52 , C07D239/86 , C07D241/04 , C07D295/185 , C07D319/18 , C07D333/20 , C07D401/06 , C07D403/06 , C07D409/06
摘要： Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and conditions, such as non-insulin dependent diabetes mellitus.
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18.发明授权BICYCLIC PYRIMIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权双环嘧啶类作为二磷酸二肽酶-IV抑制剂用于治疗或预防糖尿病
公开(公告)号：EP1841770B1
公开(公告)日：2009-11-11
申请号：EP06718696.5
申请日：2006-01-18
申请人： Merck & Co., Inc.
发明人： ASHTON, Wallace, T. , CALDWELL, Charles, G. , DONG, Hong , GAO, Ying-duo , SCAPIN, Giovanna , WEBER, Ann, E.
IPC分类号： C07D487/04 , C07D471/14 , C07D413/12 , A61K31/519 , A61K31/5377 , A61P3/06
CPC分类号： C07D487/04 , C07D495/14
摘要： The present invention is directed to novel substituted bicyclic pyrimidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DPP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）抑制剂的新型取代双环嘧啶，其可用于治疗或预防其中涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗其中涉及二肽基肽酶-IV酶的疾病中的用途。
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19.发明授权HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权HEXAHYDRODIAZEPINONE AS二肽基肽IV用于治疗或抑制剂 预防糖尿病
公开(公告)号：EP1651623B1
公开(公告)日：2008-12-17
申请号：EP04779221.3
申请日：2004-07-27
申请人： Merck & Co., Inc.
IPC分类号： C07D243/08 , A61P3/10 , A61K31/551
CPC分类号： C07D243/14 , C07D401/06 , C07D487/04
摘要： The present invention is directed to hexahydrodiazepinone compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DPP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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20.发明授权
公开(公告)号：EP1385508B1
公开(公告)日：2008-05-21
申请号：EP02753819.8
申请日：2002-03-22
申请人： Merck & Co., Inc.
IPC分类号： A61K31/40 , A61K31/426 , A61K31/427 , A61K31/4178 , A61K31/4436 , A61K31/4535 , C07D207/09 , C07D207/16 , C07D277/04 , C07D277/06 , C07D417/04 , A61P3/10
CPC分类号： C07D417/06 , C07D207/09 , C07D277/04 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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