公开(公告)号：EP0291917A3

公开(公告)日：1990-12-05

申请号：EP88107852.1

申请日：1988-05-17

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Shimada, Nobuyoshi ,  Hasegawa, Shigeru ,  Tomizawa, Takayuki ,  Saito, Seiichi ,  Shibuya, Kyoichi ,  Fujii, Akio ,  Hoshino, Hiroo ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Takahashi, Katsutoshi ,  Nishiyama, Yukihiro

IPC分类号： C07D473/06 ,  A61K31/52 ,  C07D473/16 ,  C07D473/18 ,  C07D473/40

CPC分类号： C07D473/00 ,  C07D501/00 ,  C07H19/02

摘要： This invention relates to novel oxetanocins represented by the following general formula (I):
wherein R represents a group represented by
and their pharmacologically acceptable salts which have immunosuppressive and antiviral activities.

公开(公告)号：EP0322748A1

公开(公告)日：1989-07-05

申请号：EP88121449.8

申请日：1988-12-22

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Yamashita, Takumi ,  Yamazaki, Masanori ,  Tsuchiya, Takako ,  Harada, Takashi ,  Saito, Seiichi ,  Shimada, Nobuyoshi ,  Kurokawa, Takashi ,  Hirose, Kiyonobu ,  Nishikiori, Takaaki

IPC分类号： C07D493/20 ,  C12P17/18 ,  A61K31/335

CPC分类号： C07D493/20 ,  C07H19/01 ,  C12P17/181 ,  C12R1/465

摘要： This invention relates to an antibiotic NK86-0279 of the formula:
which exhibits antifungal, antitumor, vascularizations-­inhibitory and insecticidal activities, obtainable by culturing a microorganism of the genus Streptomyces, particularly Streptomyces bottropensis NK86-0279 (FERM BP-1787) and recovering the same from the culture medium. The invention also comprises a pure culture of this microorganism and mutants and variants thereof as well as pharmaceutical compositions comprising the new antibiotic.

摘要翻译： 本发明涉及上式的抗生素NK86-0279：哪些通过培养链霉菌属，特别是链霉菌bottropensis NK86-0279的微生物展品抗真菌，抗肿瘤，vascularizations抑制和杀虫活性，得到A（FERM BP-1787 ）并从该培养基中的相同。 因此本发明包括这种微生物和突变体的纯培养物和其变体以及药物组合物，包含新的抗生素。

公开(公告)号：EP0291917B1

公开(公告)日：1994-08-24

申请号：EP88107852.1

申请日：1988-05-17

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Shimada, Nobuyoshi ,  Hasegawa, Shigeru ,  Tomizawa, Takayuki ,  Saito, Seiichi ,  Shibuya, Kyoichi ,  Fujii, Akio ,  Hoshino, Hiroo ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Takahashi, Katsutoshi ,  Nishiyama, Yukihiro

IPC分类号： C07D473/06 ,  A61K31/52 ,  C07D473/16 ,  C07D473/18 ,  C07D473/40

CPC分类号： C07D473/00 ,  C07D501/00 ,  C07H19/02

公开(公告)号：EP0322748B1

公开(公告)日：1994-04-20

申请号：EP88121449.8

申请日：1988-12-22

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Yamashita, Takumi ,  Yamazaki, Masanori ,  Tsuchiya, Takako ,  Harada, Takashi ,  Saito, Seiichi ,  Shimada, Nobuyoshi ,  Kurokawa, Takashi ,  Hirose, Kiyonobu ,  Nishikiori, Takaaki

IPC分类号： C07D493/20 ,  C12P17/18 ,  A61K31/335

CPC分类号： C07D493/20 ,  C07H19/01 ,  C12P17/181 ,  C12R1/465

公开(公告)号：EP0416605B1

公开(公告)日：1994-04-13

申请号：EP90117162.9

申请日：1990-09-06

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Kurabayashi, Katsuhiko ,  Seki, Junichi ,  Machida, Haruo ,  Yoshikawa, Hiroshi ,  Hoshino, Hiroo ,  Saito, Seiichi ,  Kitagawa, Masayuki

IPC分类号： C07H19/02 ,  A61K31/70 ,  C07H19/052

CPC分类号： C07H19/02

公开(公告)号：EP0493722A1

公开(公告)日：1992-07-08

申请号：EP91121327.0

申请日：1991-12-12

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Saito, Seiichi ,  Masuda, Akira ,  Kitagawa, Masayuki ,  Shimada, Nobuyoshi ,  Seki, Jun-ichi ,  Hoshino, Hiroo ,  Nishiyama, Yukihiro

IPC分类号： C07H19/02 ,  A61K31/70

CPC分类号： C07H19/02

摘要： It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1):

wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue

or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.

摘要翻译： 发现由以下通式（1）表示的2-卤代 - 氧杂环鸟菌素A和4'-磷酸酯：其中X表示卤素原子，R表示氢原子或磷酸残基或< 其盐具有强的抗病毒活性，可用作病毒性疾病的治疗药物的活性成分。 此外，还发现本发明的化合物的特征在于它们不被广泛存在于活体中的腺苷脱氨酶灭活并且表现出高残留活性。

公开(公告)号：EP0334250A3

公开(公告)日：1991-10-16

申请号：EP89104910.8

申请日：1989-03-18

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Saito, Seiichi ,  Hasegawa, Shigeru ,  Takahashi, Katsutoshi ,  Shimada, Nobuyoshi ,  Seki, Jun-ichi ,  Hoshino, Hiroo ,  Nishiyama, Yukihiro 8-25, Shiratori-2-chome ,  Matsubara, Kenichi ,  Nagahata, Takemitsu Senri Sakanoki Haitsu 208

IPC分类号： C07H19/16 ,  C07D473/00 ,  A61K31/52 ,  A61K31/70 ,  C12P19/40

CPC分类号： C07H19/02 ,  C07D305/06 ,  C07D305/08 ,  C07D305/10

摘要： This invention relates to oxetanocin-related compounds represented by the following formula (I):
[in formula (I), R 1 , Y and B have the following meanings: (a) R 1 represents -CH 2 0H or -CN 2 OCO-(alkyl), (b) Y represents
provided that R 2 is -H, -OH or -CHzOH and R 3 is -H, -OH, halogen atom, -CH 2 OH, lower alkyl group, -CH z -N 3 , -CH 2 -F, -N 3 , -COOH, -NH 2 , -CH 2 OSO 3 H or -CH 2 OCO-(lower alkyl), and (c) B represents a residue of purine base, (d) provided that R 1 and R 3 cannot simultaneously represente -CH 2 OH]
and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.

公开(公告)号：EP0381124A3

公开(公告)日：1991-03-27

申请号：EP90101758.2

申请日：1990-01-30

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Nishikiori, Takaaki ,  Yamazaki, Masanori ,  Saito, Seiichi ,  Shimada, Nobuyoshi ,  Kurokawa, Takashi ,  Hirose, Kiyonobu ,  Yamashita, Takumi ,  Harada, Takashi

IPC分类号： C07D498/20 ,  A61K31/365 ,  C12P17/08 ,  C12N1/20 ,  A01N43/90

CPC分类号： C07D493/20 ,  A01N43/90 ,  C12P17/181

摘要： This invention relates to an antibiotic NK130119 of the formula:
which exhibits antifungal, antitumor, vascularizations-­inhibitory and insecticidal activities.

公开(公告)号：EP0291917A2

公开(公告)日：1988-11-23

申请号：EP88107852.1

申请日：1988-05-17

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Shimada, Nobuyoshi ,  Hasegawa, Shigeru ,  Tomizawa, Takayuki ,  Saito, Seiichi ,  Shibuya, Kyoichi ,  Fujii, Akio ,  Hoshino, Hiroo ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Takahashi, Katsutoshi ,  Nishiyama, Yukihiro

IPC分类号： C07D473/06 ,  A61K31/52 ,  C07D473/16 ,  C07D473/18 ,  C07D473/40

CPC分类号： C07D473/00 ,  C07D501/00 ,  C07H19/02

摘要： This invention relates to novel oxetanocins represented by the following general formula (I):
wherein R represents a group represented by

and their pharmacologically acceptable salts which have immunosuppressive and antiviral activities.

摘要翻译： 本发明涉及由以下通式（I）表示的新型氧杂环丁酮：其中R表示由