-
11.发明公开METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR VERNDNDUNG EINES HLA-LOCUS
公开(公告)号：EP2596011A4
公开(公告)日：2014-03-19
申请号：EP11810427
申请日：2011-07-21
发明人： COLLINGWOOD TREVOR , COOPER LAURENCE J N , GREGORY PHILIP D , HOLMES MICHAEL C , MILLER JEFFREY C , REBAR EDWARD J , REIK ANDREAS , URNOV FYODOR
IPC分类号： C07K14/00
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
摘要翻译： 本文公开了用于调节HLA基因座表达或选择性删除或操纵HLA基因座或HLA调节剂的方法和组合物。
-
公开(公告)号：EP2526112A4
公开(公告)日：2013-12-04
申请号：EP11734969
申请日：2011-01-24
CPC分类号： C12N15/10 , A01H1/06 , C07K2319/81 , C12N9/22 , C12N15/8213 , C12N15/85 , C12N15/90 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted integration and/or targeted excision of one or more sequences into a cell, for example, for expression of one or more polypeptides of interest.
-
公开(公告)号：EP2370575A4
公开(公告)日：2012-05-09
申请号：EP09836506
申请日：2009-12-17
发明人： BUTLER HOLLY J , CORBIN DAVID R , DOYON YANNICK , GAO ZHIFANG , SHUKLA VIPULA K , URNOV FYODOR , WORDEN SARAH E
CPC分类号： C12N15/8213
-
公开(公告)号：EP2997146A4
公开(公告)日：2017-04-26
申请号：EP14797155
申请日：2014-05-15
发明人： CONWAY ANTHONY , COST GREGORY J , DEKELVER RUSSELL , REBAR EDWARD J , REIK ANDREAS , URNOV FYODOR , WANG JIANBIN , ZHANG H STEVE
IPC分类号： C12N15/11
CPC分类号： C12N15/907 , C07K2/00 , C07K2319/81 , C12N9/22 , C12N15/11 , C12N15/90 , C12N15/902 , C12N2320/30 , C12Y301/21004
摘要： Methods and compositions comprising single guide RNAs targeted to an endogenous mammalian β globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia 11A (BCL11A) gene, Kruppel-like factor 1 (KLF1) gene, CCR5 gene, CXCR4 gene, PPP1R12C (AAVS1) gene, hypoxanthine phosphoribosyltransferase (HPRT) gene, albumin gene, Factor VIII gene, Factor IX gene, Leucine-rich repeat kinase 2 (LRRK2) gene, Hungtingin (Htt) gene, rhodopsin (RHO) gene, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, surfactant protein B gene (SFTPB), T-cell receptor alpha (TRAC) gene, T-cell receptor beta (TRBC) gene, programmed cell death 1 (PD1) gene, Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene, human leukocyte antigen (HLA) A gene, a LMP7 gene, a Transporter associated with Antigen Processing (TAP) gene, tapasin gene (TAPBP), a class II major histocompatibility complex transactivator (CIITA) gene, a dystrophin gene (DMD), a glucocorticoid receptor gene (GR), IL2RG gene or RFX5 for genetic alteration of cells are provided.
摘要翻译： 提供了细胞的遗传改变的方法和组合物。
-
公开(公告)号：EP2890780A4
公开(公告)日：2016-08-31
申请号：EP13833658
申请日：2013-08-29
发明人： COST GREGORY J , GREGORY PHILIP D , GUSCHIN DMITRY , HOLMES MICHAEL C , MILLER JEFFREY C , PASCHON DAVID , REBAR EDWARD J , REIK ANDREAS , URNOV FYODOR , ZHANG LEI
IPC分类号： C12N5/071 , C07K14/47 , C07K14/805 , C12N9/22 , C12N15/85
CPC分类号： C12N15/85 , C07K14/4702 , C07K14/805 , C07K2319/81 , C12N9/22 , C12N15/52
摘要： Disclosed herein are nucleases and methods of using these nucleases for alteration of a globin gene and generation of cells.
-
公开(公告)号：EP2780460A4
公开(公告)日：2015-08-26
申请号：EP12850371
申请日：2012-11-16
发明人： GREGORY PHILIP D , MILLER JEFFREY C , PASCHON DAVID , REBAR EDWARD J , TAN SIYUAN , URNOV FYODOR , ZHANG LEI
IPC分类号： C12N15/87 , C07K14/195 , C12N5/04 , C12N5/071 , C12N9/22 , C12N15/63 , C12N15/90 , C12P19/34
CPC分类号： C07K14/195 , C07K2319/80 , C12N1/16 , C12N5/04 , C12N5/0602 , C12N9/1007 , C12N9/22 , C12N15/63 , C12N15/902 , C12N15/907 , C12P19/34 , C12Y301/21004
摘要： Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
-
公开(公告)号：EP2764102A4
公开(公告)日：2015-06-10
申请号：EP12838704
申请日：2012-10-04
发明人： HOLMES MICHAEL C , GREGORY PHILIP D , URNOV FYODOR
IPC分类号： C12N15/55 , A61K31/7088
CPC分类号： C12N15/85 , A61K31/7088 , A61K31/7105 , A61K31/713 , C07K2/00 , C07K2319/81 , C12N9/16 , C12N15/87 , C12Y301/21004
-
公开(公告)号：EP2640399A4
公开(公告)日：2014-08-06
申请号：EP11840913
申请日：2011-11-17
发明人： GREGORY PHILIP D , HOLMES MICHAEL C , MENDEL MATTHEW C , MENG XIANGDONG , PASCHON DAVID , REIK ANDREAS , URNOV FYODOR
IPC分类号： A61K31/7088 , A61K38/17 , A61P31/12 , A61P35/00 , C07H21/00 , C07K14/435 , C12N5/0783 , C12N9/22
CPC分类号： A61K38/1709 , A61K35/17 , C07K2319/71 , C12N9/22
摘要： Disclosed herein are methods and compositions for modulating expression of a PD1 gene.
-
19.发明公开
公开(公告)号：EP2571512A4
公开(公告)日：2013-11-20
申请号：EP11783865
申请日：2011-05-17
发明人： GREGORY PHILIP D , MILLER JEFFREY C , PASCHON DAVID , REBAR EDWARD J , TAN SIYUAN , URNOV FYODOR , ZHANG LEI
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了包含新型DNA结合结构域的多肽，编码多核苷酸的细胞和生物体，包括TALE DNA结合结构域。 还公开了使用这些新的DNA结合结构域调节内源性细胞序列的基因表达和/或基因组编辑的方法。
-
公开(公告)号：EP2419511A4
公开(公告)日：2013-08-28
申请号：EP10761996
申请日：2010-04-08
发明人： GREGORY PHILIP D , HOCKEMEYER DIRK , HOLMES MICHAEL C , JAENISH RUDOLF , SOLDNER FRANK , URNOV FYODOR , YAO SHUYUAN
CPC分类号： C12N15/86 , C12N9/22 , C12N2710/10343 , C12N2740/15043 , C12N2800/30 , C12N2830/008
摘要： Disclosed herein are methods and compositions for targeted integration of sequences of interest such as lineage-specific or cell fate reporter constructs or protein encoding sequences into stem cells.
摘要翻译： 本文公开了用于将感兴趣的序列靶向整合到干细胞中的方法和组合物，例如谱系特异性或细胞命运报道构建体或蛋白质编码序列。
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.013 秒)
