公开(公告)号：EP3546460B1

公开(公告)日：2020-07-08

申请号：EP17874613.7

申请日：2017-11-24

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： ZHANG, Ao ,  DING, Jian ,  XIE, Hua ,  SONG, Zilan ,  XUE, Yu ,  TONG, Linjiang ,  GENG, Meiyu

IPC分类号： C07D471/14 ,  C07D487/14 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02 ,  A61P29/00 ,  A61P37/02

公开(公告)号：EP3299014B1

公开(公告)日：2019-11-20

申请号：EP16795854.5

申请日：2016-05-13

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Shanghai Acebright Pharmaceuticals Co. Ltd.

发明人： GUO, Shiyan ,  GAN, Yong ,  ZHANG, Ao ,  MIAO, Zehong ,  GAO, Li ,  DING, Jian

IPC分类号： A61K9/28 ,  A61K9/48 ,  A61K31/502 ,  A61K47/32 ,  A61K47/38 ,  A61K47/40 ,  A61K47/34 ,  A61P35/00 ,  A61K47/10 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20

公开(公告)号：EP2917210B1

公开(公告)日：2019-02-27

申请号：EP13853072.0

申请日：2013-11-05

申请人： Shanghai Fochon Pharmaceutical Co. Ltd ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： WANG, Weibo ,  GENG, Meiyu ,  DING, Jian ,  ZHAO, Xingdong ,  AI, Jing ,  TIAN, Qiang ,  PENG, Xia ,  ZHANG, Weipeng ,  LIU, Hongbin ,  TAN, Haohan ,  CHEN, Ling

IPC分类号： C07D405/14 ,  A61K31/558 ,  A61P35/00

公开(公告)号：EP3418277A1

公开(公告)日：2018-12-26

申请号：EP17752701.7

申请日：2017-02-17

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： ZHANG, Ao ,  GENG, Meiyu ,  XING, Li ,  AI, Jing ,  SONG, Zilan ,  PENG, Xia ,  GU, Wangting ,  DING, Jian

IPC分类号： C07D401/12 ,  C07D213/75 ,  C07D413/12 ,  C07D417/12 ,  C07D403/12 ,  C07D405/12 ,  A61K31/4427 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61P35/00

CPC分类号： A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  C07D213/75 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： Provided in the present invention are a substituted amino six-membered nitric heterocyclic ring compound and a preparation and use thereof. In particular, provided in the present invention is a compound as shown by general formula (I) below, wherein the definition of each group is as described in the description. The compound of the present invention has an excellent tyrosine kinase inhibitory activity, and can thus be used to prepare a series of medicines for treating diseases related to tyrosine kinase inhibitory activity.

公开(公告)号：EP3018147A1

公开(公告)日：2016-05-11

申请号：EP14819337.8

申请日：2014-07-02

申请人： Shanghai Institute Of Materia Medica Chinese Academy of Sciences

发明人： DING, Jian ,  AI, Jing ,  CHEN, Yi ,  HUANG, Xun

IPC分类号： C08B37/04 ,  A61K31/734 ,  A61K31/737 ,  A61P35/00 ,  A61P35/04

CPC分类号： A61K31/737 ,  C08B37/0084 ,  C08L5/00

摘要： A polygulonic acid sulfate or pharmaceutically acceptable salt thereof, preparation method therefor and use thereof in the preparation of tumor growth and/or metastasis inhibitors are disclosed. The polygulonic acid sulfate or pharmaceutically acceptable salt thereof of the present invention can be used in the preparation of any one or more of tumor growth inhibitors, tumor metastasis inhibitors, angiogenesis inhibitors, heparanase inhibitors, C-Met enzyme inhibitors, microtubule polymerization inhibitors, actin-depolymerising factor activity inhibitors and actin-aggregation inhibitors.

摘要翻译： 甲polygulonic酸硫酸盐或其药学上可接受的盐，制备方法以及在肿瘤的生长和/或转移抑制剂的制备中的用途是游离缺失盘。 本发明的polygulonic酸式硫酸酯或药学上可接受的盐可以以肿瘤生长抑制剂，肿瘤转移抑制剂，血管生成抑制剂，乙酰肝素酶抑制剂，c-Met的酶抑制剂，微管聚合抑制剂，肌动蛋白的任何一个或多个的制备中可以使用的 -depolymerising因子抑制剂活性和肌动蛋白聚合抑制剂。

公开(公告)号：EP2881395A1

公开(公告)日：2015-06-10

申请号：EP13825341.4

申请日：2013-07-24

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： ZHANG, Ao ,  MIAO, Zehong ,  YE, Na ,  HUAN, Xiajuan ,  SONG, Zilan ,  CHEN, Chuanhuizi ,  CHEN, Yi ,  DING, Jian

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/502

摘要： Provided is a piperazinotriazole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose)polymerase-1 (PARP 1) inhibitor in the preparation of drugs for the prevention and / or treatment of PARP-related diseases.

摘要翻译： 本发明提供一种由通式表示的异构体，药学上可接受的盐，酯，前药或水合物的I或其化合物piperazinotriazole。 这样提供了用于制备所述化合物，药物组合物含有该化合物，并且作为高选择性的聚（ADP-核糖）在制备药物用于预防聚合酶-1（PARP 1）抑制剂及其使用的方法和/ 或治疗的PARP有关的疾病。

公开(公告)号：EP1995249A1

公开(公告)日：2008-11-26

申请号：EP07702109.5

申请日：2007-01-17

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： LU, Wei ,  DING, Jian ,  GAO, Heyong ,  LIN, Liping ,  CHEN, Yi

IPC分类号： C07D491/22 ,  A61K31/475 ,  A61P35/00 ,  C07D221/00 ,  C07D209/00 ,  C07D311/00

CPC分类号： C07D491/22

摘要： New camptothecin derivatives with the following structure of the formula (I), their use and the pharmaceutical compositions containing the same. The compounds of the present invention have good anti-tumor activities and good solubility in water, and can be used in development of medicines.

摘要翻译： 具有以下式（I）结构的新的喜树碱衍生物，它们的用途和含有它们的药物组合物。 本发明化合物具有良好的抗肿瘤活性和在水中的良好溶解性，可用于药物开发。

公开(公告)号：EP4219456A1

公开(公告)日：2023-08-02

申请号：EP21871504.3

申请日：2021-09-22

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： DING, Jian ,  DUAN, Wenhu ,  XIE, Hua ,  GENG, Meiyu ,  WANG, Caixia ,  ZHAN, Zhengsheng ,  GAO, Na ,  ZHANG, Yang

IPC分类号： C07D231/56 ,  A61K31/416 ,  A61P35/00

摘要： Provided is the use of a CSF1R kinase inhibitor compound or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating diseases related to the CSF1R kinase signal transduction pathway or drugs for regulating immunization.

公开(公告)号：EP4032890A1

公开(公告)日：2022-07-27

申请号：EP20866743.6

申请日：2020-09-21

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  China Pharmaceutical University

发明人： DUAN, Wenhu ,  GENG, Meiyu ,  ZHANG, Huibin ,  XIE, Zuoquan ,  ZHOU, Jinpei ,  YANG, Yifei ,  WANG, Xiyuan ,  YANG, Xiaojun ,  ZHANG, Yan ,  HU, Zhaoxue ,  DING, Jian

IPC分类号： C07D491/04 ,  A61K31/4184 ,  A61P35/00 ,  A61P31/00

摘要： Provided are a heterocyclic amide compound of general formula (I), a pharmaceutically acceptable salt thereof and a preparation method therefor, and the use of the compound in the preparation of a drug for treating diseases related to the activity of STING, in the preparation of an immunologic adjuvant, and in the preparation of a drug for activating STING.

公开(公告)号：EP4029862A1

公开(公告)日：2022-07-20

申请号：EP20861098.0

申请日：2020-09-03

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： DUAN, Wenhu ,  GENG, Meiyu ,  ZHANG, Hefeng ,  DING, Jian ,  AI, Jing ,  PENG, Xia ,  JI, Yinchun

IPC分类号： C07D401/14 ,  C07D471/04 ,  C07D405/14 ,  C07D498/04 ,  C07F7/08 ,  A61K31/506 ,  A61K31/5383 ,  A61K31/695 ,  A61K31/519 ,  A61P35/00

摘要： A compound having Axl and c-Met kinase inhibitory activity, a preparation method therefor and an application thereof. Specifically, a compound having the structure represented by formula (I), a preparation method therefor and an application thereof in the preparation of a medication for the treatment and/or prevention of tumor-associated diseases and/or kinase-related diseases.