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17 条记录 (耗时 0.027 秒)

    2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF
    5.
    发明公开
    2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF 有权
    2-ARYLBENZOFURAN-7-FORMAMIDVERBINDUNGEN，HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON

    公开(公告)号：EP2813495A1

    公开(公告)日：2014-12-17

    申请号：EP13746724.7

    申请日：2013-01-14

    申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Cisen Pharmaceutical Co. Ltd.

    发明人： YANG, Chunhao ,  MIAO, Zehong ,  DING, Jian ,  WANG, Meng ,  HE, Jinxue ,  TAN, Cun ,  CHEN, Yi

    IPC分类号： C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  A61P35/00 ,  A61P29/00

    CPC分类号： C07D307/81 ,  C07C67/08 ,  C07C67/307 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12

    摘要： Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable salt thereof, a preparation method thereof and use thereof in preparing anti-tumour drugs, wherein R 1 and R 2 are each independently hydrogen, straight or branched chained C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl or saturated 5- or 6-membered heterocyclyl containing oxygen or nitrogen; or R 1 and R 2 together with N form an unsubstituted or substituted saturated 5- or 6-membered heterocyclyl containing at least one heteroatom, wherein the heteroatom is O, N and S, the substituent is a methyl on N; R 3 is a hydrogen atom or a chlorine atom; R 4 is a hydrogen atom or a fluorine atom; X is CH, CF or N; and Y is CH, CF or N.

    摘要翻译： 本发明提供了通式Ⅰ所示的2-芳基苯并呋喃-7-甲酰胺化合物或其药理学或生理学上可接受的盐，其制备方法和其制备抗肿瘤药物的用途，其中R 1和R 2 各自独立地为氢，直链或支链C 1 -C 4烷基，C 3 -C 4环烷基或含有氧或氮的饱和5-或6-元杂环基; 或R 1和R 2与N一起形成含有至少一个杂原子的未取代或取代的饱和的5-或6-元杂环基，其中杂原子是O，N和S，取代基是N上的甲基; R 3为氢原子或氯原子; R 4为氢原子或氟原子; X是CH，CF或N; Y为CH，CF或N.

    SULFATED POLYGULONIC ACID POLYSACCHARIDE OR PHARMACEUTICAL SALT THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
    7.
    发明公开
    SULFATED POLYGULONIC ACID POLYSACCHARIDE OR PHARMACEUTICAL SALT THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF 有权
    硫酸化多糖POLYGULONSÄURE或其药用盐，方法以及这种生产的使用

    公开(公告)号：EP3018147A1

    公开(公告)日：2016-05-11

    申请号：EP14819337.8

    申请日：2014-07-02

    申请人： Shanghai Institute Of Materia Medica Chinese Academy of Sciences

    发明人： DING, Jian ,  AI, Jing ,  CHEN, Yi ,  HUANG, Xun

    IPC分类号： C08B37/04 ,  A61K31/734 ,  A61K31/737 ,  A61P35/00 ,  A61P35/04

    CPC分类号： A61K31/737 ,  C08B37/0084 ,  C08L5/00

    摘要： A polygulonic acid sulfate or pharmaceutically acceptable salt thereof, preparation method therefor and use thereof in the preparation of tumor growth and/or metastasis inhibitors are disclosed. The polygulonic acid sulfate or pharmaceutically acceptable salt thereof of the present invention can be used in the preparation of any one or more of tumor growth inhibitors, tumor metastasis inhibitors, angiogenesis inhibitors, heparanase inhibitors, C-Met enzyme inhibitors, microtubule polymerization inhibitors, actin-depolymerising factor activity inhibitors and actin-aggregation inhibitors.

    摘要翻译： 甲polygulonic酸硫酸盐或其药学上可接受的盐，制备方法以及在肿瘤的生长和/或转移抑制剂的制备中的用途是游离缺失盘。 本发明的polygulonic酸式硫酸酯或药学上可接受的盐可以以肿瘤生长抑制剂，肿瘤转移抑制剂，血管生成抑制剂，乙酰肝素酶抑制剂，c-Met的酶抑制剂，微管聚合抑制剂，肌动蛋白的任何一个或多个的制备中可以使用的 -depolymerising因子抑制剂活性和肌动蛋白聚合抑制剂。