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公开(公告)号：EP4352099A1
公开(公告)日：2024-04-17
申请号：EP22738126.6
申请日：2022-06-06
发明人： ENGLISH, Hejiao , MERLINO, Glenn , HO, Mitchell , LI, Dan , DAY, Chi-Ping
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12.发明公开
公开(公告)号：EP2998320A1
公开(公告)日：2016-03-23
申请号：EP15188264.4
申请日：2012-04-19
发明人： HO, Mitchell , FENG, Mingqian , GAO, Wei , KIM, Heungnam , DIMITROV, Dimiter S.,
IPC分类号： C07K16/30 , A61K39/395 , A61K47/48 , C07K16/28 , G01N33/574 , G01N33/68 , A61K39/00
CPC分类号： C07K16/3076 , A61K39/39558 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K14/21 , C07K16/28 , C07K16/303 , C07K16/3092 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/33 , C07K2319/55 , G01N33/57438 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2400/40
摘要： Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies described herein are capable of inhibiting HCC cell growth and migration. Provided are human monoclonal antibodies specific for GPC3 or HS chains on GPC3, including immunoglobulin molecules, such as IgG antibodies, as well as antibody fragments, such as single-domain VH antibodies or single chain variable fragments (scFv). Further provided are compositions including the antibodies that bind GPC3 or HS chains on GPC3, nucleic acid molecules encoding these antibodies, expression vectors comprising the nucleic acids, and isolated host cells that express the nucleic acids. Methods of treating cancer and/or inhibiting tumor growth or metastasis are also provided. Further provided are methods of detecting cancer in a subject and confirming a diagnosis of cancer in a subject.
摘要翻译： 本文描述了鉴定以高亲和力在GPC3上结合GPC3或硫酸乙酰肝素（HS）链的人单克隆抗体。 本文所述的抗体能够抑制HCC细胞生长和迁移。 提供了对GPC3上的GPC3或HS链特异性的人单克隆抗体，包括免疫球蛋白分子如IgG抗体，以及抗体片段，如单结构域VH抗体或单链可变片段（scFv）。 进一步提供了包含GPC3上结合GPC3或HS链的抗体，编码这些抗体的核酸分子，包含核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 还提供了治疗癌症和/或抑制肿瘤生长或转移的方法。 还提供了检测受试者中的癌症并确认受试者中癌症的诊断的方法。
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13.发明公开
公开(公告)号：EP2699603A1
公开(公告)日：2014-02-26
申请号：EP12717009.0
申请日：2012-04-19
申请人： The United States of America As Represented by the Secretary Department of Health and Human Services
发明人： HO, Mitchell , FENG, Mingqian , GAO, Wei , KIM, Heungnam , DIMITROV, Dimiter, S.
IPC分类号： C07K16/30
CPC分类号： C07K16/3076 , A61K39/39558 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K14/21 , C07K16/28 , C07K16/303 , C07K16/3092 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/33 , C07K2319/55 , G01N33/57438 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2400/40
摘要： Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies described herein are capable of inhibiting HCC cell growth and migration. Provided are human monoclonal antibodies specific for GPC3 or HS chains on GPC3, including immunoglobulin molecules, such as IgG antibodies, as well as antibody fragments, such as single-domain VH antibodies or single chain variable fragments (scFv). Further provided are compositions including the antibodies that bind GPC3 or HS chains on GPC3, nucleic acid molecules encoding these antibodies, expression vectors comprising the nucleic acids, and isolated host cells that express the nucleic acids. Methods of treating cancer and/or inhibiting tumor growth or metastasis are also provided. Further provided are methods of detecting cancer in a subject and confirming a diagnosis of cancer in a subject.
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14.发明公开
公开(公告)号：EP4429767A1
公开(公告)日：2024-09-18
申请号：EP22821820.2
申请日：2022-11-09
发明人： HO, Mitchell , KOLLURI, Aarti , LI, Nan
IPC分类号： A61P35/00 , A61K39/00 , C07K14/725 , C07K16/30
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公开(公告)号：EP4031250A1
公开(公告)日：2022-07-27
申请号：EP20804404.0
申请日：2020-10-21
发明人： HO, Mitchell , WANG, Ruixue , ST. CROIX, Brad , LI, Dan
IPC分类号： A61P35/00 , A61K47/68 , C07K16/28 , G01N33/574
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公开(公告)号：EP3883971A1
公开(公告)日：2021-09-29
申请号：EP20704743.2
申请日：2020-01-15
发明人： HO, Mitchell , PAN, Jiajia , LI, Nan
IPC分类号： C07K16/30 , C07K14/435 , A61K47/68
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17.发明授权
公开(公告)号：EP2699603B1
公开(公告)日：2016-03-02
申请号：EP12717009.0
申请日：2012-04-19
申请人： The United States of America As Represented by the Secretary Department of Health and Human Services
发明人： HO, Mitchell , FENG, Mingqian , GAO, Wei , KIM, Heungnam , DIMITROV, Dimiter, S.
IPC分类号： C07K16/30 , A61K39/395 , G01N33/68 , A61K39/00
CPC分类号： C07K16/3076 , A61K39/39558 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K14/21 , C07K16/28 , C07K16/303 , C07K16/3092 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/33 , C07K2319/55 , G01N33/57438 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2400/40
摘要： Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies described herein are capable of inhibiting HCC cell growth and migration. Provided are human monoclonal antibodies specific for GPC3 or HS chains on GPC3, including immunoglobulin molecules, such as IgG antibodies, as well as antibody fragments, such as single-domain VH antibodies or single chain variable fragments (scFv). Further provided are compositions including the antibodies that bind GPC3 or HS chains on GPC3, nucleic acid molecules encoding these antibodies, expression vectors comprising the nucleic acids, and isolated host cells that express the nucleic acids. Methods of treating cancer and/or inhibiting tumor growth or metastasis are also provided. Further provided are methods of detecting cancer in a subject and confirming a diagnosis of cancer in a subject.
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18.发明公开MESOTHELIN ANTIBODIES AND METHODS FOR ELICITING POTENT ANTITUMOR ACTIVITY 有权MESOTHELIN-ANTIKÖRPERUND VERFAHREN ZURAUSLÖSUNGEINER STARKENANTITUMORAKTIVITÄT
公开(公告)号：EP2900695A1
公开(公告)日：2015-08-05
申请号：EP13766859.6
申请日：2013-09-16
发明人： HO, Mitchell , PASTAN, Ira, H. , DIMITROV, Dimiter, S. , TANG, Zhewei , FENG, Mingqian , GAO, Wei
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/52 , C07K2317/56 , C07K2317/569 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/00 , G01N33/57492 , G01N2333/705
摘要： Described herein is the use of phage display antibody engineering technology and synthetic peptide screening to identify SD1 and SD2, human single-domain antibodies to mesothelin. SD1 recognizes a conformational epitope at the C-terminal end (residues 539-588) of human mesothelin close to the cell surface. SD2 binds full-length mesothelin. To investigate SD1 as a potential therapeutic agent, a recombinant human Fc (SD1-hFc) fusion protein was generated. The SD1-hFc protein exhibits strong complement-dependent cytotoxicity (CDC), in addition to antibody-dependent cellular cytotoxicity (ADCC), against mesothelin-expressing tumor cells. Furthermore, the SD1-hFc protein causes significant tumor growth inhibition of tumor xenografts in nude mice. SD1 and SD2 are the first human single-domain antibodies targeting mesothelin-expressing tumors.
摘要翻译： 本文描述的是使用噬菌体展示抗体工程技术和合成肽筛选来鉴定SD1和SD2，人间皮素间接抗体。 SD1识别靠近细胞表面的人间皮素C末端（残基539-588）的构象表位。 SD2结合全长间皮素。 为了研究SD1作为潜在的治疗剂，产生了重组人Fc（SD1-hFc）融合蛋白。 除抗体依赖性细胞毒性（ADCC）外，SD1-hFc蛋白对表达间皮素的肿瘤细胞具有强的补体依赖性细胞毒性（CDC）。 此外，SD1-hFc蛋白在裸鼠中引起肿瘤异种移植物的显着肿瘤生长抑制。 SD1和SD2是靶向表达间皮素的肿瘤的第一个人单域抗体。
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