公开(公告)号：EP3965897A1

公开(公告)日：2022-03-16

申请号：EP20802725.0

申请日：2020-05-06

申请人： The Board of Trustees of the Leland Stanford Junior University ,  The Children's Hospital Of Philadelphia ,  The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

发明人： HEITZENEDER, Sabine ,  MAJZNER, Robbie, G. ,  MACKALL, Crystal, L. ,  MARIS, John, M. ,  BOSSE, Kristopher, R. ,  DIMITROV, Dimiter, S. ,  ZHU, Zhongyu

IPC分类号： A61P35/00 ,  C07K16/28 ,  C07K16/30

公开(公告)号：EP2912061B1

公开(公告)日：2019-02-06

申请号：EP13773468.7

申请日：2013-09-18

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： ORENTAS, Rimas, J. ,  PASTAN, Ira, H. ,  DIMITROV, Dimiter, S. ,  MACKALL, Crystal, L.

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/00 ,  C12N5/0783

公开(公告)号：EP3328994A1

公开(公告)日：2018-06-06

申请号：EP16833684.0

申请日：2016-08-01

申请人： Memorial Sloan-Kettering Cancer Center ,  The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： SADELAIN, Michel ,  BENJAMIN, Reuben ,  DIMITROV, Dimiter, S. ,  FENG, Yang

IPC分类号： C12N5/0783 ,  C07K14/725 ,  C07K16/30

CPC分类号： C07K16/2803 ,  A61K35/17 ,  A61K2039/505 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70521 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/70

摘要： The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.

公开(公告)号：EP2900695B1

公开(公告)日：2018-01-17

申请号：EP13766859.6

申请日：2013-09-16

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

发明人： HO, Mitchell ,  PASTAN, Ira, H. ,  DIMITROV, Dimiter, S. ,  TANG, Zhewei ,  FENG, Mingqian ,  GAO, Wei

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/00 ,  G01N33/57492 ,  G01N2333/705

摘要： Described herein is the use of phage display antibody engineering technology and synthetic peptide screening to identify SD1 and SD2, human single-domain antibodies to mesothelin. SD1 recognizes a conformational epitope at the C-terminal end (residues 539-588) of human mesothelin close to the cell surface. SD2 binds full-length mesothelin. To investigate SD1 as a potential therapeutic agent, a recombinant human Fc (SD1-hFc) fusion protein was generated. The SD1-hFc protein exhibits strong complement-dependent cytotoxicity (CDC), in addition to antibody-dependent cellular cytotoxicity (ADCC), against mesothelin-expressing tumor cells. Furthermore, the SD1-hFc protein causes significant tumor growth inhibition of tumor xenografts in nude mice. SD1 and SD2 are the first human single-domain antibodies targeting mesothelin-expressing tumors.

公开(公告)号：EP1504034B1

公开(公告)日：2012-12-12

申请号：EP03733940.5

申请日：2003-05-06

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： DIMITROV, Dimiter, S. ,  ZHANG, Mei-Yun

IPC分类号： C07K16/10 ,  A61K39/21 ,  A61K31/70 ,  C07H21/04

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/605 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C12N2740/16134

公开(公告)号：EP2477658A2

公开(公告)日：2012-07-25

申请号：EP10817555.5

申请日：2010-09-16

申请人： Duke University ,  The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Feinstein Institute for Medical Research

发明人： HAYNES, Barton, F. ,  TOMARAS, Georgia ,  SHEN, Shaunna ,  DIMITROV, Dimiter, S. ,  ZHU, Zhongyu ,  HWANG, Kwan-Ki ,  CHIORAZZI, Nicholas

IPC分类号： A61K39/42 ,  C07K16/10 ,  C12N5/07 ,  A61P31/18

CPC分类号： C07K16/1063 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76

摘要： The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.

公开(公告)号：EP3685842A1

公开(公告)日：2020-07-29

申请号：EP20158336.6

申请日：2015-06-05

申请人： Memorial Sloan-Kettering Cancer Center ,  The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： ADUSUMILLI, Prasad, S. ,  SADELAIN, Michel ,  DIMITROV, Dimiter, S. ,  FENG, Yang

IPC分类号： A61K35/00 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/30 ,  A61P1/18 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/04 ,  A61P37/06 ,  A61P43/00

摘要： The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.

公开(公告)号：EP3151854B1

公开(公告)日：2020-02-26

申请号：EP15803100.5

申请日：2015-06-05

申请人： Memorial Sloan Kettering Cancer Center ,  The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： ADUSUMILLI,Prasad, S. ,  SADELAIN, Michel ,  DIMITROV, Dimiter, S. ,  FENG, Yang

IPC分类号： A61K35/00 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/30

公开(公告)号：EP2699603B1

公开(公告)日：2016-03-02

申请号：EP12717009.0

申请日：2012-04-19

申请人： The United States of America As Represented by the Secretary Department of Health and Human Services

发明人： HO, Mitchell ,  FENG, Mingqian ,  GAO, Wei ,  KIM, Heungnam ,  DIMITROV, Dimiter, S.

IPC分类号： C07K16/30 ,  A61K39/395 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/3076 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6813 ,  A61K47/6829 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/21 ,  C07K16/28 ,  C07K16/303 ,  C07K16/3092 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/55 ,  G01N33/57438 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/705 ,  G01N2400/40

摘要： Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies described herein are capable of inhibiting HCC cell growth and migration. Provided are human monoclonal antibodies specific for GPC3 or HS chains on GPC3, including immunoglobulin molecules, such as IgG antibodies, as well as antibody fragments, such as single-domain VH antibodies or single chain variable fragments (scFv). Further provided are compositions including the antibodies that bind GPC3 or HS chains on GPC3, nucleic acid molecules encoding these antibodies, expression vectors comprising the nucleic acids, and isolated host cells that express the nucleic acids. Methods of treating cancer and/or inhibiting tumor growth or metastasis are also provided. Further provided are methods of detecting cancer in a subject and confirming a diagnosis of cancer in a subject.

公开(公告)号：EP2900695A1

公开(公告)日：2015-08-05

申请号：EP13766859.6

申请日：2013-09-16

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

发明人： HO, Mitchell ,  PASTAN, Ira, H. ,  DIMITROV, Dimiter, S. ,  TANG, Zhewei ,  FENG, Mingqian ,  GAO, Wei

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/00 ,  G01N33/57492 ,  G01N2333/705

摘要： Described herein is the use of phage display antibody engineering technology and synthetic peptide screening to identify SD1 and SD2, human single-domain antibodies to mesothelin. SD1 recognizes a conformational epitope at the C-terminal end (residues 539-588) of human mesothelin close to the cell surface. SD2 binds full-length mesothelin. To investigate SD1 as a potential therapeutic agent, a recombinant human Fc (SD1-hFc) fusion protein was generated. The SD1-hFc protein exhibits strong complement-dependent cytotoxicity (CDC), in addition to antibody-dependent cellular cytotoxicity (ADCC), against mesothelin-expressing tumor cells. Furthermore, the SD1-hFc protein causes significant tumor growth inhibition of tumor xenografts in nude mice. SD1 and SD2 are the first human single-domain antibodies targeting mesothelin-expressing tumors.

摘要翻译： 本文描述的是使用噬菌体展示抗体工程技术和合成肽筛选来鉴定SD1和SD2，人间皮素间接抗体。 SD1识别靠近细胞表面的人间皮素C末端（残基539-588）的构象表位。 SD2结合全长间皮素。 为了研究SD1作为潜在的治疗剂，产生了重组人Fc（SD1-hFc）融合蛋白。 除抗体依赖性细胞毒性（ADCC）外，SD1-hFc蛋白对表达间皮素的肿瘤细胞具有强的补体依赖性细胞毒性（CDC）。 此外，SD1-hFc蛋白在裸鼠中引起肿瘤异种移植物的显着肿瘤生长抑制。 SD1和SD2是靶向表达间皮素的肿瘤的第一个人单域抗体。