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    SECOND OPINION NETWORK
    14.
    发明公开
    SECOND OPINION NETWORK 审中-公开
    第二种意见NETWORK

    公开(公告)号：EP2143030A1

    公开(公告)日：2010-01-13

    申请号：EP08780568.5

    申请日：2008-04-25

    申请人： Aperio Technologies, Inc.

    发明人： SOENKSEN, Dirk G. ,  ZIRKER-SMITH, Kathy ,  EICHHORN, Ole

    IPC分类号： G06F19/00

    CPC分类号： G16H80/00 ,  G06F19/00 ,  G06F19/321 ,  G16H50/50

    摘要： Systems and methods are provided to facilitate consultations between a referral source (e.g., labs, pathologists and patients) and a consultant (e.g., pathologist, radiologist, or other digital image analyst). Links between the various referral sources and consultants are established through a scanning center via a data communication network such as the Internet. The referral source sends a slide to the scanning center where the corresponding digital slide is posted for review and analysis by the consultant. Upon completion of the analysis and report, a digital slide conference is conducted through the scanning center that provides a venue for direct communication regarding the consultation. The scanning center may also facilitate payment from the referral source to the consultant.

    Fully automatic rapid microscope slide scanner
    16.
    发明公开
    Fully automatic rapid microscope slide scanner 审中-公开
    全自动快速显微镜载玻片扫描仪

    公开(公告)号：EP2282230A3

    公开(公告)日：2011-05-25

    申请号：EP10184724.2

    申请日：2001-03-13

    申请人： Aperio Technologies, Inc.

    发明人： Soenksen, Dirk

    IPC分类号： G02B21/00 ,  G02B21/36 ,  G06T1/00 ,  H04N1/191

    CPC分类号： G02B21/367 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/14 ,  G02B21/245 ,  G02B21/26 ,  G02B21/32 ,  G02B21/34 ,  G02B21/365 ,  H04N1/053 ,  H04N1/1903 ,  H04N1/193 ,  H04N1/19573 ,  H04N5/2256 ,  H04N5/23206 ,  H04N7/18 ,  H04N7/183 ,  H04N2201/04727 ,  H04N2201/04755

    摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample using a computer controlled microscope slide scanner for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The method provides for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The method also provides for dynamically displaying portions of the contiguous digital image. In one preferred embodiment all elements of the scanner are in single-enclosure with a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide with illumination and imaging optics consistent with transmission mode optics for diffraction-limited digital imaging.

    摘要翻译： 使用计算机控制的显微镜载片扫描仪对整个显微镜样品进行全自动快速扫描和数字化的设备和方法，用于将从连续扫描样品获得的图像条组合成单个连续的数字图像。 该方法提供以不同放大率静态显示该大数字图像的子区域，以及整个样本的缩小放大宏观图像。 该方法还提供动态显示连续数字图像的部分。 在一个优选实施例中，扫描器的所有元件均处于单一外壳中，具有到因特网或本地内联网的主要连接。 在该实施例中，优选的样本类型是具有与用于衍射受限数字成像的透射模式光学元件一致的照明和成像光学元件的显微镜载片。

    INTERMEDIATE LAYOUT FOR RESOLUTION ENHANCEMENT IN SEMICONDUCTOR FABRICATION
    18.
    发明公开
    INTERMEDIATE LAYOUT FOR RESOLUTION ENHANCEMENT IN SEMICONDUCTOR FABRICATION 审中-公开
    之间的半导体制造用布局分辨率改善

    公开(公告)号：EP1751683A4

    公开(公告)日：2008-01-23

    申请号：EP05729870

    申请日：2005-03-29

    申请人： APERIO TECHNOLOGIES INC

    发明人： WU SHAO-PO ,  WANG XIN ,  TANG HONGBO ,  HUNG MEG

    IPC分类号： G06F17/50 ,  G03F1/00 ,  G03F1/36 ,  G03F7/20

    CPC分类号： G06F17/5068 ,  G03F1/36

    摘要： Intermediate resolution-enhancement state layouts are generated based upon an original non-resolution enhanced layout of an integrated circuit and an associated resolution-enhanced layout (fig 1-11). The intermediate resolution-enhancement state layout includes fragments corresponding to parts of the original layout and biases associated with the fragments, where the biases indicate distances between the fragments and the resolution-enhanced layout. The fragments are also assigned attributes such as fragment type, fragment location, and biases. The intermediate resolution-enhancement state layouts can be combined to generate the layout for a full chip IC (fig 1-11). Two or more intermediate resolution-enhancement state layouts are assembled and are locally reconverged to adjust the resolution enhancement associated with the intermediate resolution-enhancement state layouts and obtain the intermediate resolution-enhancement state layouts for the full IC (fig 1-11).

    SYSTEM AND METHOD FOR DATA MANAGEMENT IN A LINEAR-ARRAY-BASED MICROSCOPE SLIDE SCANNER
    19.
    发明公开
    SYSTEM AND METHOD FOR DATA MANAGEMENT IN A LINEAR-ARRAY-BASED MICROSCOPE SLIDE SCANNER 审中-公开
    基于线性阵列的系统和方法进行数据管理在显微镜载玻片扫描仪

    公开(公告)号：EP1784763A4

    公开(公告)日：2014-08-20

    申请号：EP04782757

    申请日：2004-09-01

    申请人： APERIO TECHNOLOGIES INC

    发明人： CRANDALL GREG J ,  EICHHORN OLE ,  OLSON ALLEN H ,  SOENKSEN DIRK G

    IPC分类号： G06K9/00 ,  G02B21/36

    CPC分类号： G02B21/008 ,  G02B21/367 ,  G06T3/4038 ,  G06T7/32 ,  G06T2207/30004

    摘要： A data management system and method for processing, storing, and viewing the extremely large imagery data that is rapidly produced by a linear-array-based microscope slide scanner is provided. The system receives, processes, and stores imagery data produced by the linear-array-based microscope slide scanner at approximately 3 GB per minute. The data are received as a series of overlapping image stripes and combined into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The data management system enables imagery data compression while scanning and capturing new image stripes. This advantageously eliminates the overhead associated with storing uncompressed image stripes. The image compression also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The data management system efficiently converts image stripes into a high quality virtual slide that allows rapid panning and zooming by image viewing software in accordance with the individual addressed regions. The virtual slide also allows efficient processing by an algorithm framework. The data management system is costs effective and scaleable, employs standard image file formats and supports the use of virtual slides in desirable applications such as telemedicine, telepathology, microscopy education, and the analysis of high value specimens such as tissue arrays.

    SYSTEM AND METHOD TO DETERMINE SLIDE QUALITY OF A DIGITIZED MICROSCOPE SLIDE
    20.
    发明公开
    SYSTEM AND METHOD TO DETERMINE SLIDE QUALITY OF A DIGITIZED MICROSCOPE SLIDE 审中-公开
    系统和方法用于确定显微镜数字化的滑动质量PUSHER

    公开(公告)号：EP2577602A2

    公开(公告)日：2013-04-10

    申请号：EP11790514.1

    申请日：2011-06-03

    申请人： Aperio Technologies, Inc.

    发明人： EICHHORN, Ole ,  PERZ, Cindy

    IPC分类号： G06T1/00 ,  G01N33/483 ,  G01N21/00 ,  G06T7/00 ,  H04N7/26

    摘要： A system that determines the quality of a digital microscope slide by analyzing digital slide images based on complexity and spatial frequencies. An example embodiment detailed in the application may provide visual feedback on the whole slide quality by overlaying the image with a color coded "heat map" of local area quality. A user provided with the overlap image may obtain both an absolute quality measurement for the whole image and quickly identity the quality variability within the slide.