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11.发明授权
公开(公告)号：EP1993590B1
公开(公告)日：2013-12-25
申请号：EP07752090.6
申请日：2007-02-27
申请人： Biogen Idec MA Inc.
CPC分类号： A61K38/185
摘要： Disclosed are methods of increasing serum exposure of an administered glial cell line-derived neurotrophic factor (GDNF) ligand family protein by administering to a subject via systemic delivery (i) a GDNF ligand family protein, and (ii) an amount of heparin or heparan sulphate that increases serum exposure of the administered GDNF ligand family protein in the subject.
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公开(公告)号：EP2246362B1
公开(公告)日：2013-12-18
申请号：EP10173737.7
申请日：2004-02-02
申请人： Biogen Idec MA Inc.
发明人： Sah, Dinah, Wen-Yee , Pepinsky, R. Blake , Boriack-Sjodin, Paula Ann , Miller, Stephan S. , Rossomando, Anthony , Silvian, Laura
IPC分类号： C07K14/475 , A61K47/48
CPC分类号： C07K14/4756 , A61K38/00 , A61K39/00 , A61K47/60 , C07K14/475 , C07K2319/00
摘要： A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
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13.发明授权
公开(公告)号：EP1656952B1
公开(公告)日：2013-12-18
申请号：EP06003415.4
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
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公开(公告)号：EP2324844A3
公开(公告)日：2013-12-11
申请号：EP10181119.8
申请日：2000-10-05
IPC分类号： A61K38/17 , A61K39/395
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K2319/30
摘要： A receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
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15.发明公开Method for treatment of fibrosis using an antagonist of the integrin alpha-4 subunit 审中-公开一种用于纤维化的使用整合的α-4亚基的拮抗剂治疗过程
公开(公告)号：EP1666063A3
公开(公告)日：2013-11-27
申请号：EP05007878.1
申请日：2000-04-21
申请人： Biogen Idec MA Inc.
发明人： Gotwals, Philip , Lobb, Roy R.
IPC分类号： C07K16/28 , A61K39/395 , A61P11/00 , A61P37/00
CPC分类号： C07K16/2842 , A61K2039/505
摘要： Disclosed is a method of treating fibrosis in a human or animal subject. The method comprises administering to the subject an effective amount of an antagonist to VLA-4 integrin or fragment thereof.
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16.发明公开Improved antibodies having altered effector function and methods for making the same 有权改进的具有改变的效应功能的抗体，以及它们的制备方法
公开(公告)号：EP2502935A3
公开(公告)日：2013-11-13
申请号：EP11195651.2
申请日：2004-08-23
申请人： Biogen Idec MA Inc.
IPC分类号： C07K16/00 , A61K39/395 , C12Q1/37 , C12N1/20 , C12N15/00
CPC分类号： C07K16/2875 , A61K47/60 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/71
摘要： The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.
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公开(公告)号：EP2653873A1
公开(公告)日：2013-10-23
申请号：EP13169139.6
申请日：2008-02-07
申请人： Biogen Idec MA Inc.
CPC分类号： A61K9/0065 , A61K9/28 , A61K9/4891 , A61K31/137 , A61K31/194 , A61K31/197 , A61K31/225 , A61K31/277 , A61K31/436 , A61K31/4704 , A61K31/7076 , A61K38/217 , A61K45/06 , G01N33/502 , G01N33/5041 , G01N2333/90209 , G01N2800/285 , A61K2300/00
摘要： Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
摘要翻译： 本发明提供了筛选的某些方法，识别，评估和用于治疗神经系统疾病，：如，E. G.，多发性硬化症（MS）的有用神经保护性化合物。 描述的化合物通过上调的Nrf2调节的蜂窝细胞保护通路。 如此提供在治疗中的某些利用检查化合物的方法对神经系统疾病，特别是用于减慢或减少脱髓鞘，轴突损失，或神经元和少突胶质细胞死亡。
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18.发明公开Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor 审中-公开用可溶性淋巴毒素β受体脱髓鞘疾病的治疗
公开(公告)号：EP2311481A3
公开(公告)日：2013-10-16
申请号：EP10157664.3
申请日：2007-10-18
申请人： Biogen Idec MA Inc.
发明人： Browning, Jeffrey
IPC分类号： A61K38/17 , A61K39/395 , A61P25/00 , C07K14/705
CPC分类号： A61K38/1793 , C07K14/70578 , C07K2319/30
摘要： Methods of treating a demyelinating disorder using inhibitors of the lymphotoxin pathway.
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公开(公告)号：EP2609930A2
公开(公告)日：2013-07-03
申请号：EP13156164.9
申请日：2007-02-27
IPC分类号： A61K38/18
CPC分类号： A61K38/1883
摘要： Disclosed are methods of improving impaired proprioception, treating brachial plexus injuries, regenerating large and small nerve fibers, treating dorsal root nerve injuries, and improving sensory neural responses in a subject by administration of a neublastin polypeptide.
摘要翻译： 公开了改善本发明受损的方法，治疗臂丛神经损伤，再生大小神经纤维，治疗背根神经损伤，以及通过施用新斯的斯多肽多肽来改善受试者的感觉神经反应。
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20.发明授权Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists 有权使用α4整联蛋白拮抗剂治疗中枢神经系统的缺血性或出血创伤的方法
公开(公告)号：EP2140881B1
公开(公告)日：2013-04-17
申请号：EP09012818.2
申请日：2000-12-14
申请人： Biogen Idec MA Inc.
发明人： Relton, Jane , Lobb, Roy , Whalley, Eric , Adams, Steven P.
CPC分类号： C07K16/2842 , A61K39/395 , A61K2039/505 , A61K38/49 , A61K38/20 , A61K38/19 , A61K38/18 , A61K31/56 , A61K31/00 , A61K2300/00
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