公开(公告)号：EP1842559B1

公开(公告)日：2010-08-25

申请号：EP05781870.0

申请日：2005-09-02

申请人： Chongqing Haifu (Hifu) Technology Co., Ltd.

发明人： WANG, Zhibiao ,  LI, Faqi ,  XIAO, Yanbing ,  XIAO, Ziwen ,  LIU, Liping ,  WANG, Zhilong

IPC分类号： A61K41/00 ,  A61K9/127 ,  A61K31/685 ,  A61P35/00

CPC分类号： A61K41/0033 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/127 ,  A61K31/685

公开(公告)号：EP1974771A1

公开(公告)日：2008-10-01

申请号：EP06761454.5

申请日：2006-07-17

申请人： CHONGQING HAIFU(HIFU)TECHNOLOGY CO., LTD

发明人： ZHAO, Chunliang ,  MAO, Aihua ,  LEI, Guangyun

IPC分类号： A61N7/00 ,  A61B18/00 ,  A61B17/32

CPC分类号： A61N7/02 ,  A61B17/320092 ,  A61B2017/00084 ,  A61B2090/378 ,  A61N2007/0078

摘要： The present invention relates to an ultrasound treatment clamp. The ultrasound treatment clamp comprises ultrasound therapy applicators and handles connected to the ultrasound therapy applicators. The handles are clamp-shaped. The two ultrasound therapy applicators with their central axes overlapping each other are mounted face to face on the two clamps of the clamp-shaped handles respectively. A parallel moving mechanism for keeping the two ultrasound therapy applicators in parallel when moving along with clamps is connected between the two clamps. The present invention has a compact structure, a convenient operation, a low treatment cost, a capability of quickly causing a coagulative necrosis of the diseased part. Furthermore, the present invention has an abroad use in treating many kinds of diseases.

摘要翻译： 本发明涉及超声治疗夹具。 超声治疗夹具包括连接到超声治疗施用器的超声治疗施用器和手柄。 手柄是夹形的。 其两个中心轴彼此重叠的超声治疗仪分别安装在钳形手柄的两个夹具上。 在两个夹具之间连接用于在与夹具一起移动时保持两个超声治疗施放器并联的平行移动机构。 本发明具有结构紧凑，操作方便，治疗成本低，能够迅速引起患病部位凝固性坏死的能力。 此外，本发明在国外用于治疗多种疾病。

公开(公告)号：EP1847294A1

公开(公告)日：2007-10-24

申请号：EP05781862.7

申请日：2005-08-26

申请人： CHONGQING HAIFU(HIFU)TECHNOLOGY CO., LTD

发明人： CHEN, Wenzhi ,  WEN, Yingang ,  Wang, Zhibao ,  WANG, Zhilong ,  LIN, Tao

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B90/14 ,  A61B2090/378

摘要： The present invention pertains to an ultrasound therapy system and more specifically, to a high-intensity focused ultrasound (HIFU) therapy apparatus guided by image registration and fusion method. The therapy system of the present invention comprises a central control means; an acoustic energy applicator; a mechanical driving and locating means of said acoustic energy applicator; a real-time B-mode ultrasound image guiding device. Further the therapy system of the present invention comprises an immobilization means for body position. By the help of this immobilization means for body position, real-time B-mode ultrasound images can be registered with diagnosis images, and then on the basis of registration, said B-mode ultrasound images are fused with said diagnosis images for guiding said therapy. Comparing to the existed technical solutions in this field, the present invention has effectively solved the difficult problems in high-intensity focused ultrasound therapy and particularly for tumor treatment with a low cost. And it provides a very practical technical solution, which can be easily applied to clinical treatment of tumors.

摘要翻译： 本发明涉及一种超声治疗系统，更具体地，涉及由图像配准和融合方法引导的高强度聚焦超声（HIFU）治疗装置。 本发明的治疗系统包括中央控制装置; 声能施加器; 所述声能施加器的机械驱动和定位装置; 实时B模式超声图像引导装置。 此外，本发明的治疗系统包括用于身体位置的固定装置。 借助于身体位置的这种固定装置，实时B模式超声图像可以与诊断图像一起登记，然后在注册的基础上，将所述B模式超声图像与用于引导所述治疗的所述诊断图像融合 。 与现有技术方案相比，本发明有效地解决了高强度聚焦超声治疗中的难题，特别是低成本肿瘤治疗。 它提供了一个非常实用的技术解决方案，可以很容易地应用于肿瘤的临床治疗。

公开(公告)号：EP1842560A1

公开(公告)日：2007-10-10

申请号：EP05781912.0

申请日：2005-08-31

申请人： Chongqing Haifu (Hifu) Technology Co., Ltd.

发明人： WANG, Zhilong ,  WANG, Zhibiao ,  LI, Faqi ,  XIAO, Yanbing ,  XIAO, Ziwen ,  LIU, Liping

IPC分类号： A61K49/00 ,  A61K49/22

CPC分类号： A61K41/0052 ,  A61K41/0028

摘要： The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF = ηPt / v (unit: J/mm 3 ), and refers to the HIFU energy needed to effectively treat a tumor per unit volume of the tumor, wherein, η=0.7; P refers to the total acoustic power of HIFU source (unit: W); t refers to the total time of HIFU treatment (unit: s); V refers to the volume of HIFU-induced lesions (unit: mm 3 ). If the amount of EEF at the target location before administration of the enhancement agent is defined as EEF (base) and the amount of EEF at the target location after administration of the enhancement agent is defined as EEF (measurement) , the ratio between EEF (base) and EEF (measurement) is more than 1, preferably more than 2, and more preferably over 4. The use of the enhancement agent for HIFU treatment of the present invention makes it possible to treat deep-seated tumors. In addition, patients with hepatic tumors can be effectively treated without removal of ribs. Accordingly, the present invention discloses methods for increasing acoustic energy deposition at target location during HIFU treatment and screening the enhancement agents for HIFU treatment.

摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）治疗的增强剂，其在HIFU治疗之前施用于患者，并且可以降低待HIFU治疗的目标位置处的EEF水平。 EEF由以下表达式表示：EEF =·Pt / v（单位：J / mm 3），并且是指每单位体积肿瘤有效治疗肿瘤所需的HIFU能量，其中，= 0.7; P指HIFU源的总声功率（单位：W）; t指HIFU治疗的总时间（单位：s）; V指HIFU诱导的病变体积（单位：mm 3）。 如果将增强剂施用前的目标位置处的EEF量定义为EEF（碱基），并且将施用增效剂后的目标位置处的EEF的量定义为EEF（测量值），则EEF 碱）和EEF（测量）大于1，优选大于2，更优选超过4.使用本发明的HIFU治疗用增强剂可以治疗深层肿瘤。 此外，可以有效地治疗肝肿瘤患者，而不需要排除肋骨。 因此，本发明公开了在HIFU处理期间增加目标位置处的声能沉积并筛选HIFU处理增强剂的方法。

公开(公告)号：EP1839677A1

公开(公告)日：2007-10-03

申请号：EP05781799.1

申请日：2005-09-02

申请人： CHONGQING HAIFU(HIFU)TECHNOLOGY CO., LTD

发明人： WANG, Zhibiao ,  LI, Faqi ,  XIAO, Ziwen ,  XIAO, Yanbing ,  LIU, Liping ,  WANG, Zhilong

IPC分类号： A61K49/00 ,  A61K49/22 ,  A61K9/127 ,  A61K31/685

CPC分类号： A61K41/0033 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/685 ,  A61K49/226

摘要： The present invention discloses a fluoro-carbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2µm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100°C, and the amount of the core material in the enhancement agent is 5-200ml/L. The fluoro-carbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the ability of clinical HIFU treatment to ablate tumor cells can be significantly improved. Accordingly, the present invention discloses use of a fluoro-carbon emulsion enhancement agent for HIFU treatment during HIFU treatment.

摘要翻译： 本发明公开了一种用于HIFU处理的氟碳乳液增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括由膜形成材料包封的芯材料和由水性介质组成的连续相的不连续相; 不连续相均匀分散在连续相中，不连续相的粒径为0.1-2μm; 增强剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃下经历液相 - 气相转变的液体组成，增强剂中芯材的量为5-200ml / L。 本发明的用于HIFU处理的氟碳乳液增强剂可以显着改变目标位置的声学环境，并且可以在HIFU处理期间增加目标位置处的声能沉积。 最终，临床HIFU治疗消融肿瘤细胞的能力可以显着提高。 因此，本发明公开了在HIFU处理中使用氟碳乳液增强剂进行HIFU处理。

公开(公告)号：EP1837051A1

公开(公告)日：2007-09-26

申请号：EP05771731.6

申请日：2005-08-02

申请人： CHONGQING HAIFU(HIFU)TECHNOLOGY CO., LTD

发明人： CHEN, Wenzhi ,  WANG, Zhibiao ,  WANG, Whilong ,  LIN, Tao ,  ZHAO, Chunliang

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B2090/378

摘要： The apparatus for high-intensity focused ultrasound therapy of the present invention usually comprises a ultrasound transducer, an image acquisition device, a driving unit for driving said ultrasound transducer and mechanical drive means for mechanically driving said ultrasound transducer and image acquisition device together. Additionally, this apparatus for high-intensity focused ultrasound therapy further comprises a signal processing unit connected to image acquisition device for receiving and saving the original images of the target area prior to treatment and for receiving and saving the images of the target area in a certain time during high-intensity focused ultrasound (HIFU) treatment and for evaluating the therapeutic effects according to the images of the target area before and after treatment, and a control unit respectively connected to signal processing unit, driving unit and mechanical driving means. When the signal processing unit judges that the therapeutic requirements have been met, the control unit controls the driving unit and mechanical driving means to stop the working of ultrasound transducer and when the signal processing unit judges that the therapeutic requirements have not been met, the control unit controls the driving unit and mechanical driving means to make the ultrasound transducer continue to work.

摘要翻译： 本发明的高强度聚焦超声治疗装置通常包括超声波换能器，图像采集装置，用于驱动所述超声换能器的驱动单元和用于将所述超声换能器和图像采集装置机械地驱动的机械驱动装置。 此外，该高强度聚焦超声治疗装置还包括连接到图像获取装置的信号处理单元，用于在处理之前接收和保存目标区域的原始图像，并且在一定程度上接收和保存目标区域的图像 在高强度聚焦超声（HIFU）治疗期间的时间和根据治疗前后目标区域的图像评价治疗效果的时间，以及分别连接到信号处理单元，驱动单元和机械驱动装置的控制单元。 当信号处理单元判定满足治疗要求时，控制单元控制驱动单元和机械驱动装置来停止超声波换能器的工作，并且当信号处理单元判断未满足治疗要求时，控制 单元控制驱动单元和机械驱动装置，以使超声换能器继续工作。