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公开(公告)号：EP3623372A1
公开(公告)日：2020-03-18
申请号：EP19207235.3
申请日：2015-12-29
发明人： IOANNIDIS, Stephanos , TALBOT, Adam Charles , FOLLOWS, Bruce , BUCKMELTER, Alexandre Joseph , WANG, Minghua , CAMPBELL, Ann-Marie , SCHMIDT, Darby Rye , GUERIN, David Joseph , CARAVELLA, Justin A , DIEBOLD, R. Bruce , ERICSSON, Anna , LANCIA, David R., Jr.
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P9/00 , A61P25/28 , A61P35/00
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:
where m, n, X 1 , X 2 , R 1 -R 5 , R 5' and R 6 are described herein.-
公开(公告)号：EP3201185B1
公开(公告)日：2018-11-21
申请号：EP15771465.0
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, Jr., David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14 , A61P35/00 , A61K31/4704 , A61K31/4709
CPC分类号： C07D401/12 , A61K31/4704 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：EP2112150B1
公开(公告)日：2013-10-16
申请号：EP08103665.9
申请日：2008-04-22
发明人： Schoop, Andreas Dr. , Backes, Alexander Dr. , Vogt, Joachim Dr. , Neumann, Lars Dr. , Eickhoff, Jan Dr. , Hannus, Stefan Dr. , Hansen, Kerrin , Amon, Peter Dr. , Ivanov, Igor Dr. , Borgmann, Matthias Dr. , Smith, Chase , Kluge, Arthur F. , Murthi, Krishna , Casaubon, Rebecca
IPC分类号： C07D471/04 , A61K31/505 , A61P35/00
CPC分类号： C07D471/04
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公开(公告)号：EP3681885B1
公开(公告)日：2024-02-28
申请号：EP18833127.6
申请日：2018-09-14
发明人： SCHILLER, Shawn E.R. , HERBERTZ, Torsten , LI, Hongbin , GRAVES, Bradford , MISCHKE, Steven , WEST, Angela V. , ERICSSON, Anna , DOWNING, Jennifer R.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP3720442B1
公开(公告)日：2022-12-28
申请号：EP19728271.8
申请日：2019-05-16
发明人： KELLY, Patrick F. , COLLIS, Alan , DAVIS, Jeff , WALKER, Duncan , ASHWELL, Susan , THOMSON, Blythe , WEI, Lu
IPC分类号： A61K31/4704 , A61K31/4709 , A61P35/00 , A61P35/02
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公开(公告)号：EP3483164B1
公开(公告)日：2020-03-04
申请号：EP18209919.2
申请日：2018-03-20
发明人： ERICSSON, Anna , GREEN, Neal , GUSTAFSON, Gary , HAN, Bingsong , LANCIA JR., David, R , MITCHELL, Lorna , RICHARD, David , SHELEKHIN, Tatiana , SMITH, Chase C. , WANG, Zhongguo , ZHENG, Xiaozhang
IPC分类号： C07D487/04 , A61K31/407 , C07D519/00 , A61P7/00
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公开(公告)号：EP3458448A1
公开(公告)日：2019-03-27
申请号：EP17790287.1
申请日：2017-04-25
IPC分类号： C07D401/04 , C07D403/04 , C07D471/04
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公开(公告)号：EP3448859A1
公开(公告)日：2019-03-06
申请号：EP18716455.3
申请日：2018-03-20
发明人： ERICSSON, Anna , GREEN, Neal , GUSTAFSON, Gary , HAN, Bingsong , LANCIA, JR., David R. , MITCHELL, Lorna , RICHARD, David , SHELEKHIN, Tatiana , SMITH, Chase C. , WANG, Zhongguo , ZHENG, Xiaozhang
IPC分类号： C07D487/04 , A61K31/407 , C07D519/00 , A61P7/00
CPC分类号： C07D487/04 , A61K9/0053 , A61P7/00 , C07D519/00
摘要： Compositions for the activation of PKR are provided, as well as therapeutic administration of the compositions for the treatment of pyruvate kinase-related medical conditions, such as pyruvate kinase deficiency (PKD).
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公开(公告)号：EP3194376B1
公开(公告)日：2018-10-24
申请号：EP15778433.1
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, Jr., David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/12 , A61P35/00 , A61K31/4704 , A61K31/4709 , C07D471/04 , C07D401/14
CPC分类号： C07D401/12 , A61K31/47 , A61P35/00 , C07D401/14 , C07D471/04
摘要： where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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20.发明公开3-ALKYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开作为HDAC抑制剂的3-烷基-4-氨基 - 双环[4,5,0]羟基酸
公开(公告)号：EP3253747A1
公开(公告)日：2017-12-13
申请号：EP16706457.5
申请日：2016-02-02
发明人： ZHENG, Xiaozhang , NG, Pui Yee , HAN, Bingsong , THOMASON, Jennifer R. , ZABLOCKI, Mary-Margaret , LIU, Cuixian , DAVIS, Heather , RUDNITSKAYA, Aleksandra , LANCIA JR., David , BAIR, Kenneth W. , MILLAN, David S. , MARTIN, Matthew W.
IPC分类号： C07D403/06 , C07D413/06 , C07D243/14 , C07D267/12 , A61K31/551 , A61K31/553 , A61P35/00
CPC分类号： C07D267/14 , C07D243/14 , C07D267/12 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/107 , C07D493/08 , C07D495/10 , C07D498/04 , C07D498/08
摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC,
e.g ., HDAC6, having a Formula I:, where R, L, X
1 , X
2 , X
3 , X
4 , Y
1 , Y
2 , Y
3 , and Y
4 are described herein.
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