公开(公告)号：EP1776622A4

公开(公告)日：2009-12-23

申请号：EP05761948

申请日：2005-06-30

申请人： UNIV ALBERTA ,  MATRIKON INC

发明人： CHOUDHURY MD ALI A SHOUKAT ,  SHAH SIRISH L ,  THORNHILL NINA F ,  SHOOK DAVID

IPC分类号： G05B23/00

CPC分类号： G05B23/0229

公开(公告)号：EP1765395A4

公开(公告)日：2008-06-18

申请号：EP05735623

申请日：2005-04-18

申请人： UNIV ALBERTA

发明人： SUNWOO HOON ,  SIM JEONG S

IPC分类号： A61K39/395 ,  A23L1/305 ,  A23L2/66 ,  A61P1/00 ,  A61P37/00 ,  C07K16/02 ,  C07K16/16

CPC分类号： C07K16/16 ,  A23L33/17 ,  A61K2039/505 ,  C07K16/02 ,  C07K2317/11

公开(公告)号：EP1730199A4

公开(公告)日：2008-05-21

申请号：EP05714647

申请日：2005-03-21

申请人： UNIV ALBERTA

发明人： VASANTHAN THAVARATNAM ,  TEMELLI FERAL

IPC分类号： C08B37/00 ,  A61K9/16 ,  A61K9/50 ,  A61K9/62 ,  A61K47/36 ,  C08L5/00 ,  C08L99/00

CPC分类号： C08B37/0024 ,  A61K9/1652 ,  A61K9/5036 ,  C08L5/00 ,  C12P19/04

摘要： The present invention relates to native cell wall compositions characterized by a relatively intact wall structure and uses of the compositions as micro-encapsulation agents. In a preferred embodiment this invention relates to native cell wall compositions derived from oat or barley flour wherein the native cell wall composition is composed primarily of beta-glucan.

公开(公告)号：EP1653999A4

公开(公告)日：2007-10-03

申请号：EP04761658

申请日：2004-08-12

申请人： UNIV ALBERTA

发明人： BARABAS ARPAD Z

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61P37/00 ,  A61P37/02 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K39/0008 ,  A61K39/395 ,  A61K2300/00

摘要： The invention provides compositions and methods for increasing the levels of an autoantigen-specific IgM antibody in a mammal and, thus, decreasing the levels of a circulating autoantigen in a mammal. Using these autoantigen-specific IgM anti-bodies, the invention provides compositions and methods for ameliorating an autoimmune disease in a mammal. In one aspect, the invention provides compositions and methods for increasing the levels of an antigen-specific IgG antibody in a mammal and, thus, decreasing the levels of a circulating antigen in a mammal. Using these antigen-specific IgG antibodies, the invention provides compositions and methods for ameliorating a disease or condition in a mammal, e.g., a cancer or a foreign antigen, such as a pathogen.

公开(公告)号：EP0966692A4

公开(公告)日：2000-07-12

申请号：EP98911598

申请日：1998-03-13

申请人： UNIV ALBERTA ,  BRYMAN DOUGLAS ,  UNIV FRASER SIMON ,  UNIV VICTORIA ,  UNIV BRITISH COLUMBIA ,  TRIUMF

发明人： BRYMAN DOUGLAS

IPC分类号： G01T1/20 ,  G01T1/185

CPC分类号： G01T1/185

摘要： A gamma ray detector for determining the position of gamma ray interactions has at least one module (1). Each module has a converter (2) for converting gamma rays (3) to charged particles (4), a scintillator (5) for emitting light in response to charged particles produced by the converter, a photodectector (6) to determine when light has been emitted from the scintillator, a two-coordinate position detector (7) for determining the X and Y coordinates of charged particles interacting with the position detector, and a signal device (8) for signaling the presence of emitted light in the photodetector and for activating the position detector.

公开(公告)号：EP0958508A4

公开(公告)日：2000-05-10

申请号：EP98909989

申请日：1998-02-05

申请人： UNIV ALBERTA ,  CTI INC ,  UNIV FRASER SIMON ,  UNIV VICTORIA ,  UNIV BRITISH COLUMBIA ,  TRIUMF

发明人： MOISAN CHRISTIAN ,  ANDREACO MARK S ,  PAQUET SEBASTIAN ,  ROGERS JOEL G

IPC分类号： G01T1/20 ,  G01T1/202

CPC分类号： G01T1/2002 ,  G01T1/202

摘要： The present invention relates to light guides (1) capable of encoding the transverse and longitudinal coordinates of light emission induced by the interaction of photons in an array of a plurality of the light guides. Each light guide has at least two discrete crystal segments (4) adjacently disposed along a common longitudinal axis of the light guide (1). Between adjacent segments is a boundary layer (7) having less light transmission than the light transmission of the crystal segments (4). A light absorbing mask (8) increases light adsorption in a segment (4). Photons enter the light guide (1) and cause the emission of scintillation light which is delivered in different and resolvable quantities to light sensing devices. The differences in quantity of delivered light is caused by successive decreases in light transmission to light transmitting end (5) caused at least in part by the boundary layers (7). The differences in quantity of light establish the segment from which the light emission took place.

公开(公告)号：EP2517136A4

公开(公告)日：2017-03-22

申请号：EP10838451

申请日：2010-12-15

申请人： UNIV ALBERTA

发明人： HARYNUK JAMES ,  SINKOV NIKOLAI

IPC分类号： G06F19/00 ,  G06F17/10

CPC分类号： G06F19/24 ,  G06F19/10 ,  G06F19/707 ,  G06K9/622

公开(公告)号：EP2893343A4

公开(公告)日：2016-08-31

申请号：EP13835859

申请日：2013-09-06

申请人： UNIV ALBERTA ,  HANNOVER MED HOCHSCHULE

发明人： LANDI ABDOLAMIR ,  HOUGHTON MICHAEL ,  TYRRELL LORNE D ,  LANKISCH TIM ,  WEISMUELLER TOBIAS ,  MANNS MICHAEL

IPC分类号： G01N33/48 ,  G06F19/00

CPC分类号： G01N33/6893 ,  A61K45/00 ,  G01N33/6827 ,  G01N2333/521 ,  G01N2333/523 ,  G01N2333/5443 ,  G01N2333/916 ,  G01N2800/085 ,  G06F19/24 ,  G06F19/3431 ,  G06F19/345 ,  G16H50/20 ,  G16H50/30 ,  Y02A90/22 ,  Y02A90/24 ,  Y02A90/26

摘要： The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.

摘要翻译： 本公开提供了用于促进受试者中炎性肝病诊断的方法和组合物。 方法和组合物通常涉及单独或与嗜酸细胞活化趋化因子-1（E1）的水平以及任选地与CCL22水平以及进一步任选的IL15水平检测嗜酸细胞活化趋化因子-3（E3）水平。 这些水平可以用于促进自身免疫性肝炎（AIH），原发性胆汁性肝硬化（PBC）和原发性硬化性胆管炎（PSC）中的至少一种的肝脏疾病的诊断，和/或促进AIH， PBC和PSC。 本公开的方法和组合物也用于促进受试者的治疗决定。

公开(公告)号：EP2890708A4

公开(公告)日：2016-06-08

申请号：EP13832369

申请日：2013-08-28

申请人： UNIV ALBERTA ,  DOSCHAK MICHAEL ,  YANG YANG ,  BHANDARI KRISHNA HARI

发明人： DOSCHAK MICHAEL ,  YANG YANG ,  BHANDARI KRISHNA HARI

IPC分类号： C07K14/65 ,  A61K38/28 ,  A61K47/48 ,  A61P19/08 ,  C07K14/62 ,  C07K14/635 ,  C07K17/08 ,  C08F299/02

CPC分类号： C07K14/62 ,  A61K31/663 ,  A61K38/29 ,  A61K47/548 ,  A61K47/60 ,  C07K14/635 ,  C07K14/65 ,  C08F299/02

摘要： Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair.

公开(公告)号：EP2595949A4

公开(公告)日：2016-03-30

申请号：EP11809115

申请日：2011-07-21

申请人： UNIV ALBERTA

发明人： CURTIS JONATHAN ,  LIU GUOGUANG ,  OMONOV TOLIBJON ,  KHARRAZ EREDDAD

IPC分类号： C07C67/343 ,  C07C67/08 ,  C07C67/31 ,  C07C69/708 ,  C08G18/36 ,  C08G63/12 ,  C08G65/28

CPC分类号： C07C67/08 ,  C07C67/31 ,  C08G18/36 ,  C11C3/00 ,  C11C3/003 ,  C11C3/006 ,  C07C69/708 ,  C07C69/732 ,  C07C69/734

摘要： A method for preparing polyols from fatty acid substrates such as free fatty acids, alkyl esters of fatty acids, mono-glycerides, diglycerides, and triglycerides. The method comprises the steps of (a) epoxidizing an unsaturated fatty acid substrate and (b) hydroxylating the epoxidized fatty acid substrate with at least one diol to produce a polyol or a blend of polyols. The method may be varied to produce polyols with desired functionality, molecular weights, or viscosity.