公开(公告)号：EP3205716A1

公开(公告)日：2017-08-16

申请号：EP15848765.2

申请日：2015-10-07

申请人： Universidad de Murcia

发明人： ROMAR ANDRES, Raquel ,  COY FUSTER, María Pilar

IPC分类号： C12N5/073 ,  A61K35/48 ,  A61P15/08

CPC分类号： C12M21/06 ,  A01K67/00 ,  A01K67/02 ,  A61B17/43 ,  A61K35/48 ,  B01L3/50 ,  B01L2200/06 ,  C12M1/00 ,  C12N5/0604 ,  C12N2517/10 ,  C12Q1/02

摘要： Processing and use of fluids from the reproductive tract (biofluids) to improve the in vitro production of mammalian embryos comprising the following steps: a) fractionation and processing of biofluids through a sorting, purification, lyophilization and subsequent storage; b) a method of sperm capacitation in a culture medium supplemented with biofluids; c) in vitro fertilization in a medium enriched with biofluids and d) subsequent in vitro culture with development of the obtained embryos to any stage of preimplantational development in culture media supplemented with biofluids.

摘要翻译： 处理和使用来自生殖道的流体（生物流体）以改善哺乳动物胚胎的体外生产，包括以下步骤：a）通过分选，纯化，冻干和随后的储存分馏和处理生物流体; b）补充生物流体的培养基中的精子获能方法; c）在富含生物流体的培养基中进行体外受精，和d）随后的体外培养以及获得的胚胎发育至补充有生物流体的培养基中的任何植入前发育阶段。

公开(公告)号：EP3060163A4

公开(公告)日：2017-04-19

申请号：EP14855550

申请日：2014-10-24

申请人： UNIV COLORADO STATE RES FOUND

发明人： HANSEN THOMAS R ,  PRENNI JESSICA ,  NETT TERRY M ,  MCSWEENEY KEVIN ,  ROMERO JARED

IPC分类号： A61D19/00

CPC分类号： G01N33/689 ,  A01K29/005 ,  A01K67/00 ,  G01N33/6866 ,  H01J49/0027 ,  H01J49/26

摘要： The present invention provides compositions and methods for detection schemes for ascertaining pregnancy status of an animal. The compositions and methods employ interferon-tau (IFNT) and/or antibodies specific for IFNT. Methods of the present invention detect the presence of IFNT in samples obtained from animals as an early indicator of pregnancy. Methods are provided to identify non-pregnant animals so that management decisions regarding rebreeding can be made earlier compared to existing approaches.

摘要翻译： 本发明提供了用于确定动物怀孕状态的检测方案的组合物和方法。 组合物和方法使用IFNτ特异性的干扰素τ（IFNT）和/或抗体。 本发明的方法检测从动物获得的样品中的IFNτ的存在作为怀孕的早期指标。 提供了用于识别非怀孕动物的方法，使得与现有方法相比，可以更早地进行关于再生的管理决策。

公开(公告)号：EP2851426A3

公开(公告)日：2015-08-19

申请号：EP14197970.8

申请日：2011-09-27

申请人： Arrowhead Research Corporation

发明人： Boylan, John Frederick ,  Bramlage, Birgit ,  Hossbach, Markus ,  Reidhaar-Olson, John

IPC分类号： C12N15/113 ,  A61P35/00 ,  C12N9/02

CPC分类号： C12N15/1137 ,  A01K67/00 ,  A61K48/00 ,  C12N9/0093 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/335 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/50 ,  C12N2310/53 ,  C12Y117/04001

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

摘要翻译： 本发明涉及用于抑制RRM2基因表达的双链核糖核酸（dsRNA）。 本发明还涉及包含dsRNA或核酸分子的药物组合物或编码其​​的载体与药学上可接受的载体一起; 使用所述药物组合物治疗由RRM2基因表达引起的疾病的方法; 以及抑制细胞中RRM2表达的方法。

公开(公告)号：EP2630240A1

公开(公告)日：2013-08-28

申请号：EP11767402.8

申请日：2011-09-27

申请人： Arrowhead Research Corporation

发明人： BOYLAN, John Frederick ,  BRAMLAGE, Birgit ,  HOSSBACH, Markus ,  REIDHAAR-OLSON, John

IPC分类号： C12N15/113 ,  A61P35/00

CPC分类号： C12N15/1137 ,  A01K67/00 ,  A61K48/00 ,  C12N9/0093 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/335 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/50 ,  C12N2310/53 ,  C12Y117/04001

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

摘要翻译： 本发明涉及用于抑制RRM2基因表达的双链核糖核酸（dsRNA）。 本发明还涉及包含dsRNA或核酸分子的药物组合物或编码其​​的载体与药学上可接受的载体一起; 使用所述药物组合物治疗由RRM2基因表达引起的疾病的方法; 以及抑制细胞中RRM2表达的方法。

公开(公告)号：EP1490487A4

公开(公告)日：2007-08-29

申请号：EP03723815

申请日：2003-03-25

申请人： GTC BIOTHERAPEUTICS INC

发明人： MELICAN DAVID ,  BUTLER ROBIN E ,  GAVIN WILLIAM G

IPC分类号： A01K67/027 ,  A01K67/00 ,  C12N5/02 ,  C12N5/10 ,  C12N15/09 ,  C12N15/877 ,  C12N15/00 ,  C12N5/00 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12N15/87

CPC分类号： C12N15/8772 ,  A01K67/00

摘要： The present invention provides data to demonstrate that the fusion performance of a cell-line in procedures involving fusion and cleavage indices either alone or in combination are a means for selecting a cell lines that will be successful in a nuclear transfer or microinjection program. This technique and method of selecting a cell line offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production of live offspring in various mammalian non-human species including goats, pigs, rodents, primates, rabbits and cattle.

公开(公告)号：EP1615492A2

公开(公告)日：2006-01-18

申请号：EP04759332.2

申请日：2004-04-09

申请人： Magee-Womens Health Corporation ,  Schatten, Gerald ,  Simerly, Calvin ,  Navara, Christopher

发明人： SCHATTEN, Gerald ,  SIMERLY, Calvin ,  NAVARA, Christopher

IPC分类号： A01K67/00 ,  C12N15/00

CPC分类号： A01K67/00 ,  A01K67/027 ,  A01K2217/05 ,  A01K2227/106 ,  A01K2267/03 ,  C12N5/10 ,  C12N15/873 ,  C12N15/8776

摘要： The present invention is directed to various methodologies to make NT a practical procedure for animals, specifically, primates including human and non-human primates. Furthermore, the methods and molecular components provided by the the present invention provide a practical means for producing embryos with desired characteristics. In a specific embodiment, the methodology of the present invention comprises introducing nuclei having desired characteristics along with one or more molecular components into an egg, culturing the egg to produce a viable embryo, transferring the embryo to the oviducts of a female, and prouducing a cloned animal.

公开(公告)号：EP0444024A1

公开(公告)日：1991-09-04

申请号：EP89902874.0

申请日：1989-02-06

申请人： BIOSYS

发明人： FRIEDMAN, Milton, J.

IPC分类号： A01N1 ,  A01K67 ,  A01N63 ,  C12N1

CPC分类号： C12N1/04 ,  A01K67/00 ,  A01K67/033 ,  A01N63/00 ,  A01N25/04 ,  A01N1/02 ,  A01N2300/00

摘要： Est décrit un procédé pour induire un état anhydrobiotique chez les sujets jeunes infectieux des nématodes entomogènes. Ces sujets jeunes infectieux anhydrobiotiques se prêtent particulièrement au stockage et au transport. Ce procédé permet une dessiccation soigneusement contrôlée desdits sujets en les mettant en suspension dans de l'huile, et en éliminant graduellement l'eau à l'aide d'un agent déshydratant, notamment en utilisant de l'air à une humidité relative inférieure à 100 %, en présence éventuelle d'un tensio-actif.

公开(公告)号：EP0351921A2

公开(公告)日：1990-01-24

申请号：EP89201885.4

申请日：1989-07-19

申请人： MERCK & CO. INC.

发明人： Dixon, Richard A. F. ,  Patchett, Arthur A. ,  Sigal, Irving S. ,  Strader, Catherine D.

IPC分类号： A01K67/00 ,  C12N15/85

CPC分类号： C12N15/8509 ,  A01K67/00 ,  A01K2217/05 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/02 ,  C07K14/70571 ,  C12N15/85 ,  C12N2830/008

摘要： Modified Beta Adrenergic Receptors having the amino acid residue in position 113 substituted by certain other amino acids have been synthesized. These modified receptors interact with novel ligands that do not react with the natural Asp 113 containing receptors. Transgenic animals containing this modified receptor will respond to novel ligands which will not interact with the normal receptor.
RELATED APPLICATION
The present application is a continuation-in-­part of our copending U.S. Patent Application Serial No. 223,182, filed 22 July, 1988.

摘要翻译： 已经合成了由某些其他氨基酸取代的113位氨基酸残基的修饰的β肾上腺素能受体。 这些修饰的受体与不与天然Asp 113含有受体反应的新配体相互作用。 含有该修饰的受体的转基因动物将对不与正常受体相互作用的新配体产生反应。 相关申请本申请是1988年7月22日提交的共同未决的美国专利申请系列号223,182的部分继续申请。

公开(公告)号：EP3412147A1

公开(公告)日：2018-12-12

申请号：EP16889298.2

申请日：2016-02-05

申请人： Kao Corporation

发明人： HASUMURA, Takahiro

IPC分类号： A01K67/00

CPC分类号： A01K67/00

摘要： A method of identifying individual zebrafish ( Danio rerio ), containing the steps of:
observing a striped pattern for each of an anal fin and a caudal fin of each individual of two or more zebrafish in side view;
determining characteristics of each individual from the observed striped pattern; and
identifying each individual on the basis of the characteristics obtained.

公开(公告)号：EP3060163B1

公开(公告)日：2018-05-16

申请号：EP14855550.1

申请日：2014-10-24

申请人： COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： HANSEN, Thomas R. ,  PRENNI, Jessica ,  NETT, Terry M. ,  MCSWEENEY, Kevin ,  ROMERO, Jared

IPC分类号： A61D19/00

CPC分类号： G01N33/689 ,  A01K29/005 ,  A01K67/00 ,  G01N33/6866 ,  H01J49/0027 ,  H01J49/26

摘要： The present invention provides compositions and methods for detection schemes for ascertaining pregnancy status of an animal. The compositions and methods employ interferon-tau (IFNT) and/or antibodies specific for IFNT. Methods of the present invention detect the presence of IFNT in samples obtained from animals as an early indicator of pregnancy. Methods are provided to identify non-pregnant animals so that management decisions regarding rebreeding can be made earlier compared to existing approaches.