公开(公告)号：EP2748192B1

公开(公告)日：2018-11-14

申请号：EP12825669.0

申请日：2012-08-23

申请人： Foundation Medicine, Inc.

发明人： LIPSON, Doron ,  STEPHENS, Philip, James ,  PARKER, Alexander, N. ,  DOWNING, Sean, R. ,  HAWRYLUK, Matthew, J.

IPC分类号： C07K14/82 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/513 ,  A61K31/517 ,  C12Q1/6886 ,  C12N9/14 ,  C12N15/113 ,  A61K31/47

CPC分类号： A61K31/517 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/47 ,  A61K31/513 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/14 ,  C12N15/1135 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

摘要： Novel RET fusion molecules and uses are disclosed.

公开(公告)号：EP3388057A1

公开(公告)日：2018-10-17

申请号：EP18161847.1

申请日：2012-09-10

申请人： Vizuri Health Sciences LLC

发明人： BUCKS, Daniel ,  BIRBARA, Philip J

IPC分类号： A61K31/045 ,  A61K31/05 ,  A61K31/125 ,  A61K31/165 ,  A61K31/618 ,  A61K45/06 ,  A61K9/06 ,  A61K9/14 ,  A61K47/10 ,  A61K9/08 ,  A61P29/00

CPC分类号： A61K31/165 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/08 ,  A61K31/045 ,  A61K31/05 ,  A61K31/125 ,  A61K31/196 ,  A61K31/35 ,  A61K31/351 ,  A61K31/352 ,  A61K31/513 ,  A61K31/60 ,  A61K31/618 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00

摘要： The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.

公开(公告)号：EP3377050A1

公开(公告)日：2018-09-26

申请号：EP16867149.3

申请日：2016-11-17

申请人： The Trustees of Columbia University in the City of New York

发明人： BRACHMAN, Rebecca, Anne ,  DENNY, Christine, Ann ,  HEN, Rene

IPC分类号： A61K31/135 ,  A61P25/22 ,  A61P25/24 ,  A61P23/00 ,  A61P29/00

CPC分类号： A61K31/138 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K31/135 ,  A61K31/198 ,  A61K31/401 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/453 ,  A61K31/513 ,  A61K31/517 ,  A61K31/53 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00 ,  A61P25/22 ,  A61P25/24

摘要： Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount, of an antagonist of the glutamate N-methyl-D-aspartate (NMDA) receptor, such as ketamine, or a pharmaceutically acceptable salt or derivative thereof, is administered to a subject prior to a stressor.

公开(公告)号：EP2979700B1

公开(公告)日：2018-09-26

申请号：EP14773638.3

申请日：2014-03-27

申请人： Taiho Pharmaceutical Co., Ltd.

发明人： OKABE, Hiroyuki

IPC分类号： A61K31/7072 ,  A61K31/4745 ,  A61K31/506 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/7072 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/513 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K2300/00

摘要： Provided is a novel combination therapy using an FTD/TPI combination drug which exhibits remarkable antitumor effects, and few side effects. An antitumor agent is characterized in that the FTD/TPI combination drug is administered, using a reduced amount of trifluridine, at a dose in the range of 35 to 70 mg/m 2 /day and CPT-11 is administered at a dose in the range of 45 to 144 mg/m 2 /day.

公开(公告)号：EP3368546A1

公开(公告)日：2018-09-05

申请号：EP16860972.5

申请日：2016-10-28

申请人： Tarveda Therapeutics, Inc.

发明人： WOOSTER, Richard ,  WHALEN, Kerry ,  BAZINET, Patrick Rosaire ,  BILODEAU, Mark T. ,  KADIYALA, Sudhakar ,  PERINO, Samantha ,  SWERYDA-KRAWIEC, Beata ,  SHINDE, Rajesh R.

IPC分类号： C07K14/00 ,  A61P35/00

CPC分类号： A61K47/64 ,  A61K31/404 ,  A61K31/436 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5365 ,  A61K31/655 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/6937 ,  A61K51/083 ,  A61P35/00 ,  C07K14/72

摘要： Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

公开(公告)号：EP3368064A1

公开(公告)日：2018-09-05

申请号：EP15907392.3

申请日：2015-10-29

申请人： CLS Therapeutics Limited

发明人： GENKIN, Dmitry ,  TETS, Georgy Viktorovich ,  TETS, Viktor Veniaminovich

IPC分类号： A61K38/47 ,  A61P35/00

CPC分类号： C12Y301/22001 ,  A61K31/513 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K38/465 ,  A61K45/06 ,  C12Y301/21001 ,  A61K2300/00

摘要： The invention relates to the use of a deoxyribonuclease (DNase) enzyme for prevention or amelioration of toxicity associated with various cytostatic and/or cytotoxic chemotherapeutic compounds and radiation therapy.

公开(公告)号：EP3357917A1

公开(公告)日：2018-08-08

申请号：EP18161153.4

申请日：2011-02-16

申请人： Aragon Pharmaceuticals, Inc.

发明人： SMITH, Nicholas, D ,  BONNEFOUS, Celine ,  JULIEN, Jackaline, D.

IPC分类号： C07D401/04 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4439 ,  A61K31/5025 ,  A61P5/26 ,  A61P5/28 ,  A61P35/00

CPC分类号： C07D401/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/635 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon androgen receptors.

公开(公告)号：EP2867232B1

公开(公告)日：2018-08-08

申请号：EP13731771.5

申请日：2013-06-26

申请人： F. Hoffmann-La Roche AG

发明人： DO, Steven ,  HU, Huiyong ,  KOLESNIKOV, Aleksandr ,  TSUI, Vickie, H. ,  WANG, Xiaojing

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  A61P3/00 ,  A61P5/00 ,  A61P25/00

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

摘要： 5-Azaindazole compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：EP2568964B1

公开(公告)日：2018-08-01

申请号：EP11706248.9

申请日：2011-03-03

申请人： Evonik Röhm GmbH

发明人： NALAWADE, Pravin ,  SHETTY, Smitha ,  RAVISHANKAR, Hema ,  GADHINGLAJKAR, Shripad ,  GRYCZKE, Andreas ,  PETEREIT, Hans-Ulrich ,  NOLLENBERGER, Kathrin

IPC分类号： A61K9/14 ,  A61K31/427 ,  A61K9/16 ,  A61K9/48

CPC分类号： A61K31/513 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/4866 ,  A61K31/427

摘要： The invention relates to a pharmaceutical dosage form comprising one or more antiretroviral active ingredients in the form of a solid dispersion or solid solution in a matrix, wherein said matrix comprises an amino(meth)acrylate copolymer, characterized in that the matrix does not contain any essential amounts of pharmaceutically acceptable surfactants with an HLB value from 12 to 18 and in that the matrix comprises a mono carboxylic acid or an alcohol with 12 to 22 carbon atoms or both.

公开(公告)号：EP3348263A1

公开(公告)日：2018-07-18

申请号：EP18151859.8

申请日：2009-06-02

申请人： Boehringer Ingelheim International GmbH

发明人： KLEIN, Thomas ,  MARK, Michael ,  NIESSEN, Heiko ,  THOMAS, Leo

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/422 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/513 ,  A61K31/522 ,  A61P1/16 ,  A61K45/06 ,  A61K31/155 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/519 ,  A61K31/53

CPC分类号： A61K31/40 ,  A61K31/155 ,  A61K31/403 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/522 ,  A61K31/53 ,  A61K45/06 ,  A61P1/16 ,  A61K2300/00

摘要： The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing non alcoholic fatty liver diseases (NAFLD).