公开(公告)号：EP4358976A1

公开(公告)日：2024-05-01

申请号：EP22827749.7

申请日：2022-06-22

申请人： AZURA OPHTHALMICS LTD

发明人： BOSWORTH, Charles ,  ALSTER, Yair ,  EPSTEIN-BARASH, Hila ,  RAFAELI, Omer ,  GLEESON, Marc

IPC分类号： A61K33/04 ,  A61K47/02 ,  A61K31/07

CPC分类号： A61K33/04 ,  A61K47/06 ,  A61K47/44 ,  A61K9/0048 ,  A61K9/06 ,  A61P1/00 ,  A61K31/60

公开(公告)号：EP4352058A1

公开(公告)日：2024-04-17

申请号：EP22821087.8

申请日：2022-06-10

申请人： Neuronascent, Inc.

发明人： KELLEHER-ANDERSSON, Judith

IPC分类号： C07D471/02 ,  A61K31/33 ,  A61K31/395 ,  C07D471/00 ,  A61K31/00

CPC分类号： C07D215/46 ,  C07D451/04 ,  C07D401/04 ,  A61P25/00 ,  A61K31/551 ,  A61K31/496 ,  A61K9/10 ,  A61K47/44

公开(公告)号：EP3411014A1

公开(公告)日：2018-12-12

申请号：EP17708583.4

申请日：2017-02-02

申请人： Apharm S.r.l.

发明人： PIZZONI, Angelo ,  PIZZONI, Paolo

IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K47/44 ,  A61K31/343

CPC分类号： A61K9/0014 ,  A61K31/343 ,  A61K31/496 ,  A61K45/06 ,  A61K47/10 ,  A61K47/44 ,  A61K2300/00

摘要： The present invention refers to new topical compositions comprising usnic acid. The invention also comprises the use of said compositions, possibly in association with other active principles, for the therapy of skin diseases, including eczemas, dermatitis, skin wounds of various origin, sores, burns, psoriasis, proliferative keratosis and skin diseases caused by microbial and fungal agents.

公开(公告)号：EP3000474B1

公开(公告)日：2018-11-28

申请号：EP14801762.7

申请日：2014-05-20

申请人： Taejoon Pharm. Co., Ltd.

发明人： LEE, Joon Youb ,  SHIN, Youn Jae ,  RYU, Sang-Rok

IPC分类号： A61K9/107 ,  A61K47/44 ,  A61K47/26 ,  A61K47/10 ,  A61K47/14 ,  A61K38/13 ,  A61P27/02

CPC分类号： A61K9/1075 ,  A61K9/0048 ,  A61K38/13 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44

摘要： The present invention relates to an ophthalmic nanoemulsion composition and a method for preparing the same which increases the solubility of cyclosporine as an active ingredient and improves the stability of the ophthalmic composition by mixing cyclosporine, a nonaqueous solvent, an emulsifier, and an aqueous solvent, and a method for preventing or treating dry eye syndrome using the same. The ophthalmic nanoemulsion composition according to the present invention is characterized by having an average particle size of 200 nm or less, preferably 100 nm or less, and having a very narrow particle distribution. Therefore, sterilizing filtration is available, stability is improved and has superior effect in clinical enhancement of foreign body sensation and visual disturbance, and thus the ophthalmic nanoemulsion composition of the present disclosure can be effectively used as an ophthalmic composition.

公开(公告)号：EP3402457A1

公开(公告)日：2018-11-21

申请号：EP17738735.4

申请日：2017-01-16

申请人： Nanyang Technological University ,  Agency for Science, Technology and Research

发明人： LIM, Sierin ,  SARKER, Mridul ,  TOMCZAK, Nikodem

IPC分类号： A61K8/06 ,  A61K9/107 ,  A61K47/42

CPC分类号： A61K8/062 ,  A23L27/70 ,  A23L33/10 ,  A61K8/0279 ,  A61K8/64 ,  A61K9/1075 ,  A61K47/42 ,  A61K47/44 ,  A61K2800/10 ,  A61K2800/33 ,  A61K2800/412 ,  A61K2800/56 ,  A61Q19/00

摘要： The present invention relates to a Pickering emulsion comprising an aqueous phase, an oil phase and a nanoparticle, wherein the nanoparticle is a protein cage. The protein cage is preferably a Bacillus stearothermophilus E2 protein of pyruvate dehydrogenase multi-enzyme complex or an E2LC2 protein. Preferably the aqueous or oil phase of the Pickering emulsion com prises an agent, or the protein cage is coupled to or loaded with an agent, wherein the agent is a therapeutic, nutritional, nutraceutical or cosmetic agent. The invention further includes use of the Pickering emulsions disclosed herein in pharmaceutical, cosmetic, or food applications, or as a controlled release delivery system, and use of protein cages as emulsifiers in Pickering emulsions.

公开(公告)号：EP3266446B1

公开(公告)日：2018-11-21

申请号：EP16382321.4

申请日：2016-07-07

申请人： Laboratorios SALVAT, S.A.

发明人： IZQUIERDO TORRES, Francisca ,  MARCHAN SANCHO, Sandra ,  DELGADO GAÑÁN, Isabel

IPC分类号： A61K9/107 ,  A61P27/02

CPC分类号： A61K9/0048 ,  A61K9/1075 ,  A61K31/18 ,  A61K31/4166 ,  A61K36/45 ,  A61K47/14 ,  A61K47/44

摘要： The present invention relates to a sterile ophthalmic composition comprising castor oil and a medium chain triglyceride, to its use in medicine, in particular for the treatment and/or prevention of an ocular disease selected from the group consisting of dry eye, conjunctivitis, dermatitis, blepharitis, entropion, floppy eyelid syndrome, thyroid ophthalmopathy, pterygium, conjunctivochalasis, epithelial damage induced by preservatives, epithelial or anterior chamber damage induced by ocular surgery, limbal cell deficiency, corneal ulcers induced by physical or chemical agents, keratitis, episcleritis and uveitis.

公开(公告)号：EP3192515B1

公开(公告)日：2018-11-21

申请号：EP17150991.2

申请日：2017-01-11

申请人： Immunopharm AG

发明人： BIEBERSCHULTE, Werner ,  GRIMM, Christine ,  ROHAN, Charles Fernando

IPC分类号： A61K31/575 ,  A61K47/10 ,  A61K47/44

CPC分类号： A61K31/575 ,  A61K9/0019 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/28 ,  A61K47/44

公开(公告)号：EP3189827B1

公开(公告)日：2018-11-21

申请号：EP17150557.1

申请日：2017-01-06

申请人： Evergreen Land Limited

发明人： VIDAL, Nicolas ,  LESGARDS, Jean-François

IPC分类号： A61K8/26 ,  A61Q13/00 ,  A61K8/73 ,  A61K47/00 ,  A61K9/107 ,  A61K8/06 ,  A61P17/02

CPC分类号： A61K36/61 ,  A01N25/02 ,  A01N25/04 ,  A01N31/06 ,  A01N65/28 ,  A61K8/26 ,  A61K8/34 ,  A61K8/345 ,  A61K8/678 ,  A61K8/731 ,  A61K8/922 ,  A61K8/965 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/22 ,  A61K47/38 ,  A61K47/44 ,  A61K2800/10 ,  A61K2800/52 ,  A61K2800/522 ,  A61K2800/524 ,  A61K2800/592 ,  A61Q19/00

公开(公告)号：EP2544707B1

公开(公告)日：2018-11-21

申请号：EP11754034.4

申请日：2011-03-09

申请人： Dignity Health

发明人： GARFIELD, Robert ,  SHI, Leili ,  SHI, Shao-Qing

IPC分类号： A61P15/06 ,  A61K39/00 ,  A61K31/4422 ,  A61K31/405 ,  A61K31/57 ,  A61K9/00 ,  A61K47/44

CPC分类号： A61K31/4422 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0034 ,  A61K9/0043 ,  A61K31/405 ,  A61K31/57 ,  A61K47/44 ,  A61K2300/00

摘要： The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone.

公开(公告)号：EP3399963A1

公开(公告)日：2018-11-14

申请号：EP17736445.2

申请日：2017-01-06

申请人： Viramal Limited

发明人： BOLOGNA, William ,  LARSEN, Finn

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K47/10 ,  A61K47/38 ,  A61K47/14 ,  A61K31/568 ,  A61K31/56 ,  A61K31/196

CPC分类号： A61K31/58 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/06 ,  A61K9/14 ,  A61K31/196 ,  A61K31/565 ,  A61K31/568 ,  A61K31/57 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44

摘要： Disclosed herein are gel compositions for enhanced transdermal delivery of an active ingredient into a serum of a subject through production of a reservoir of the active ingredient in the stratum corneum of the subject. Also disclosed herein are methods of using the gel composition to at least partially ameliorate a condition, and kits comprising the gel composition.