公开(公告)号：EP1562488A4

公开(公告)日：2007-12-26

申请号：EP03754961

申请日：2003-09-25

申请人： ETHICON INC

发明人： SCALZO HOWARD ,  FISCHER JEROME A ,  CERWIN ROBERT

IPC分类号： A61B17/06 ,  A61L17/00

CPC分类号： A61L17/005 ,  A61B17/06114 ,  A61B17/06166 ,  A61B2017/00889 ,  A61B2050/3005 ,  A61L2300/202 ,  A61L2300/404 ,  A61L2300/606

摘要： ABSTRACTA packaged medical device produced according to the steps of positioning an antimicrobial agent source within a package comprising an inner surface, positioning a medical device within the package; and subjecting the package,the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device.

公开(公告)号：EP1327893B1

公开(公告)日：2006-07-12

申请号：EP03250210.6

申请日：2003-01-14

申请人： Johnson & Johnson Vision Care, Inc.

发明人： Rathore, Osman

IPC分类号： G02B1/04 ,  A61L27/54 ,  C08J7/12

CPC分类号： A61L27/54 ,  A61L2300/202 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2430/16 ,  C08J7/12 ,  G02B1/043

公开(公告)号：EP1508601A1

公开(公告)日：2005-02-23

申请号：EP04077310.3

申请日：2004-08-13

申请人： Closure Medical Corporation

发明人： Narang, Upvan

IPC分类号： C09J4/00 ,  A61L24/06

CPC分类号： A61L24/06 ,  A61L24/0015 ,  A61L2300/202 ,  A61L2300/404 ,  C08K3/015 ,  C08K5/136 ,  C08L33/06 ,  C08L33/068 ,  C08L35/04 ,  C08L2666/04

摘要： A monomeric adhesive composition includes a polymerizable monomer, such as a 1,1-disubstituted monomer such as a cyanoacrylate, and an antimicrobial agent, wherein the antimicrobial agent is a phenolic active compound. Examples of suitable phenolic active compounds include halogenated phenol compounds such as chlorinated phenol compounds (such as triclosan) and brominated phenol compounds.

摘要翻译： 单体粘合剂组合物包括可聚合单体，例如1,1-二取代单体如氰基丙烯酸酯和抗微生物剂，其中抗微生物剂是酚类活性化合物。 合适的酚类活性化合物的实例包括卤代酚化合物如氯化酚化合物（如三氯生）和溴化苯酚化合物。

公开(公告)号：EP1165155A1

公开(公告)日：2002-01-02

申请号：EP00920019.7

申请日：2000-03-30

申请人： The Trustees of Columbia University in the City of New York

发明人： MODAK, Shanta ,  SAMPATH, Lester

IPC分类号： A61L29/16 ,  A61L27/54 ,  A61L31/16 ,  A61L17/00 ,  A61L15/44 ,  A61L2/18

CPC分类号： A61L31/16 ,  A01N59/16 ,  A61L2/18 ,  A61L15/44 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/21 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/45 ,  D06M11/83 ,  D06M13/432 ,  D06M16/00 ,  Y10T428/1352 ,  A01N31/16 ,  A01N31/12 ,  A01N31/08 ,  A01N25/34 ,  A01N2300/00

摘要： The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

公开(公告)号：EP0874655A4

公开(公告)日：2001-05-02

申请号：EP96945335

申请日：1996-12-23

申请人： UNIV COLUMBIA

发明人： MODAK SHANTA ,  SAMPATH LESTER

IPC分类号： A61L15/44 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L31/00 ,  A61M5/32

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1331 ,  Y10T428/1352 ,  A61L29/06 ,  C08L83/04 ,  C08L75/04 ,  A61L27/507

摘要： The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.

公开(公告)号：EP0868192A4

公开(公告)日：2001-01-24

申请号：EP96929870

申请日：1996-09-03

申请人： ISP INVESTMENTS INC

发明人： CHAKRABARTI SIBU ,  MENON ANIL

IPC分类号： A01N59/12 ,  A61K8/00 ,  A61K8/19 ,  A61K8/20 ,  A61K8/34 ,  A61K8/72 ,  A61K8/81 ,  A61K8/86 ,  A61K9/70 ,  A61K31/00 ,  A61K31/79 ,  A61K38/00 ,  A61K47/30 ,  A61K47/48 ,  A61L26/00 ,  A61P17/00 ,  A61Q19/00 ,  A61K33/18 ,  A61L25/00

CPC分类号： A61L26/0076 ,  A01N59/12 ,  A61K9/7015 ,  A61K47/58 ,  A61L26/0066 ,  A61L2300/202 ,  A61L2300/404 ,  A01N2300/00

摘要： This invention relates to a fast drying iodine complex solution having film forming capability and skin substantivity which solution consists essentially of: (a) between 1 and 25 wt.% polyvinylpyrrolidone/iodine (PVP/I) complex; (b) between 5 and 15 wt.% vinylpyrrolidone/vinyl acetate copolymer (PVP/VA); (c) between 0.5 and 1.5 wt.% non-plasticizing polyethylene glycol (PEG); (d) between 35 and 75 wt.% C1 to C4 alkanol; (e) between 12 and 35 wt.% deionized water; and (f) between 0 and 2.5 wt.% of 1-vinyl-3-(E)-ethylidene pyrrolidone, based on total composition. The invention also relates to the method of preparing the film forming solution which has a drying time of less than 5 minutes.

摘要翻译： 本发明涉及一种具有成膜能力和皮肤亲和力的快速干燥碘络合物溶液，该溶液基本上由以下组成：（a）1至25重量％的聚乙烯吡咯烷酮/碘（PVP / I）络合物; （b）5至15wt％乙烯基吡咯烷酮/乙酸乙烯酯共聚物（PVP / VA）; （c）0.5-1.5wt％的非增塑聚乙二醇（PEG）; （d）35至75重量％的C1至C4链烷醇; （e）12至35重量％的去离子水和（f）基于总组合物在0至2.5重量％之间的1-乙烯基-3-（E） - 亚乙基吡咯烷酮。 本发明还涉及制备干燥时间小于5分钟的成膜溶液的方法。

公开(公告)号：EP0964706A4

公开(公告)日：2000-12-27

申请号：EP96933263

申请日：1996-10-14

申请人： PRISCOTT PAUL KENNETH

发明人： PRISCOTT PAUL KENNETH

IPC分类号： A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L27/00 ,  A61L29/00

CPC分类号： A61L29/16 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/202 ,  A61L2300/404

公开(公告)号：EP0889742A1

公开(公告)日：1999-01-13

申请号：EP97906036.0

申请日：1997-03-07

申请人： Leatherite Pty. Ltd.

发明人： GRAY, John Patrick

IPC分类号： A61L15

CPC分类号： A61L15/46 ,  A61L15/18 ,  A61L2300/202 ,  A61L2300/404

摘要： The invention relates to a bandage or wound dressing fabricated from a natural or synthetic film-forming material, such as a hydrophobic polymeric membrane, incorporating a therapeutically effective amount of a therapeutically active (e.g. anti-microbial) compound within the matrix thereof. A preferred therapeutically active compound is Triclosan, which when incorporated into the bandage or wound dressing provides continuous inherent control of the growth of a broad range of microorganisms, which promotes better wound care management and wound healing.

公开(公告)号：EP0856318A1

公开(公告)日：1998-08-05

申请号：EP97402615.5

申请日：1997-11-03

申请人： MedLogic Global Corporation

发明人： Greff, Richard J. ,  Byram, Michael M.

IPC分类号： A61L25/00 ,  A61L31/00

CPC分类号： A61L26/0066 ,  A01N59/12 ,  A61K9/7015 ,  A61K31/79 ,  A61L24/0015 ,  A61L26/0014 ,  A61L2300/202 ,  A61L2300/404 ,  A61L2300/414 ,  A01N25/34 ,  A01N25/24 ,  A01N25/10 ,  A01N2300/00 ,  C08L35/04

摘要： Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film on mammalian skin.

摘要翻译： 公开了包含相容的抗微生物剂，特别是相容的含碘抗微生物剂的氰基丙烯酸酯组合物。 这些组合物提供在哺乳动物皮肤上原位形成抗微生物聚合氰基丙烯酸酯膜。

公开(公告)号：EP0855191A2

公开(公告)日：1998-07-29

申请号：EP97402617.1

申请日：1997-11-03

申请人： MedLogic Global Corporation

发明人： Greff, Richard J. ,  Byram, Michael M.

IPC分类号： A61L25/00 ,  A61L31/00

CPC分类号： A61L26/0014 ,  A01N59/12 ,  A61K31/275 ,  A61K31/79 ,  A61L24/0015 ,  A61L26/0066 ,  A61L2300/202 ,  A61L2300/404 ,  C09D4/00 ,  A01N2300/00 ,  C08L35/04 ,  C08F222/32

摘要： Antimicrobial cyanoacrylate compositions are applied to non-suturable, superficial wound surfaces. In situ polymerization of the cyanoacrylate ester provides for a polymeric film over the wound which promotes wound healing and retards infection of the wound.

摘要翻译： 治疗和/或不可缝合表面的伤口的保护包括抗微生物组合物（I）的应用至伤口和（I）的聚合区域，以加入分离蒙皮部分和/或抗微生物聚合物膜的形状粘附于 应用领域。 （i）包含可聚合的腈基丙烯酸酯（II）和碘分子与生物相容性聚合物（III）的复合物。 伤口表浅切口和/或磨损哪个不通过皮肤皮下层的真皮层渗透。