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公开(公告)号：EP3375462A1
公开(公告)日：2018-09-19
申请号：EP18170238.2
申请日：2012-03-09
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 500:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto, wherein the hyperbranched polymer is a dendrimer.
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12.发明公开BIFUNCTIONAL MATERIAL FOR NITRIC OXIDE STORAGE AND PRODUCTION AND USE THEREOF IN THERAPY 有权使用双功能材料，用于存储及一氧化氮生产情况
公开(公告)号：EP2083946A1
公开(公告)日：2009-08-05
申请号：EP07824588.3
申请日：2007-11-19
申请人： The University Court of the University of St Andrews , The University Court Of The University of Edinburgh
CPC分类号： B01J29/072 , A01N25/08 , A01N25/26 , A01N59/00 , A61K8/19 , A61K8/26 , A61K9/143 , A61K33/00 , A61K33/06 , A61K33/34 , A61K45/06 , A61K47/02 , A61L15/44 , A61L27/20 , A61L27/34 , A61L27/507 , A61L27/52 , A61L29/16 , A61L31/16 , A61L33/0011 , A61L33/0064 , A61L2300/114 , A61Q19/00 , B01J20/02 , B01J20/0237 , B01J20/0281 , B01J20/0288 , B01J20/06 , B01J20/18 , B01J20/186 , B01J20/3234 , B01J23/72 , B01J29/143 , B01J29/46 , B01J2220/42 , Y02A50/409
摘要： The present invention relates to a bifunctional material which comprises copper and which is capable of storing nitric oxide (NO), as well as catalytically producing nitric oxide from a suitable precursor. The material typically includes a zeolite and the copper may be part of, or separate from the zeolite. In this manner the material may include a single bifunctional material; that is, a material which is capable of both storing NO and catalytically producing NO, such as Cu-MFI or Cu-X. Alternatively the material may include at least two components, a first component to store NO, such as a zeolite Zn-LTA, and a further component including Cu(I), such as Cu2O, to catalytically produce NO from a suitable precursor. The bifunctional material may be used in a pharmaceutical, neutraceutical or cosmetic preparation, or comprised in a medical article, a cosmetic and/or personal hygiene product.
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公开(公告)号：EP0941131B1
公开(公告)日：2004-03-10
申请号：EP97942443.9
申请日：1997-09-11
CPC分类号： A61L27/26 , A61L27/20 , A61L27/34 , A61L27/52 , A61L33/0064
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公开(公告)号：EP1199104A3
公开(公告)日：2003-01-15
申请号：EP01123563.7
申请日：2001-10-01
CPC分类号： B01L3/5082 , A61B5/15003 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61L33/0064 , A61L33/064 , C08L39/06
摘要： A plastic medical article, such as a catheter or blood collection tube, is coated with a crosslinked hydrogel permanently bound to the inside wall of the tube. The hydrophilic surface provided by the hydrogel prevents adherence of blood components to the surface, and the permanent adherence of the hydrogel prevents its removal by blood.
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公开(公告)号：EP0516749B1
公开(公告)日：1994-05-18
申请号：EP91905942.8
申请日：1991-02-28
发明人： MERRILL, Edward, W.
CPC分类号： B01D67/0088 , A61K47/6903 , A61K47/6957 , A61L33/0029 , A61L33/0064 , A61L33/068 , B01D67/0093 , B01D2323/30 , B01D2323/34 , B01J20/321 , B01J20/3219 , B01J20/3272 , B01J20/3282 , B01J20/3287 , C07K1/22 , G01N33/545 , G02B1/043 , Y10S435/975 , Y10S436/828 , C08L71/02
摘要： This invention pertains to a method for immobilizing polyethylene oxide (PEO) star molecules in the form of hydrogels. The PEO star molecules are biocompatible and demonstrate non-thrombogenic properties. As such, the PEO star molecules have numerous uses for biomedical applications. The hydrogels contain a high percentage of terminal hydroxyl groups for attachment of affinity ligands and can be used for separating and purifying therapeutic proteins.
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公开(公告)号：EP0516749A1
公开(公告)日：1992-12-09
申请号：EP91905942.0
申请日：1991-02-28
发明人： MERRILL, Edward, W.
CPC分类号： B01D67/0088 , A61K47/6903 , A61K47/6957 , A61L33/0029 , A61L33/0064 , A61L33/068 , B01D67/0093 , B01D2323/30 , B01D2323/34 , B01J20/321 , B01J20/3219 , B01J20/3272 , B01J20/3282 , B01J20/3287 , C07K1/22 , G01N33/545 , G02B1/043 , Y10S435/975 , Y10S436/828 , C08L71/02
摘要： Procédé d'immobilisation de molécules étoilées d'oxyde de polyéthylène (PEO) sous forme d'hydrogels. Les molécules étoilées de PEO sont biocompatibles et présentent des propriétés non thrombogènes. A ce titre, lesdites molécules étoilées de PEO trouvent de nombreuses utilisations pour les applications biomédicales. Les hydrogels contiennent un pourcentage élevé de groupes hydroxyles terminaux pour la fixation de ligands d'affinité et peuvent être utilisés pour séparer et purifier des protéines thérapeutiques.
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公开(公告)号：EP0258317A4
公开(公告)日：1990-01-23
申请号：EP87901283
申请日：1987-02-17
IPC分类号： C08J7/14 , A61L26/00 , A61L33/00 , C08F265/04
CPC分类号： C08F265/04 , A61L33/0064 , A61L33/0082 , A61L33/0088 , Y10S623/924 , Y10T428/24479 , A61L33/064 , C08L33/14 , A61L27/16 , A61L27/52 , A61F2/06 , C08F220/34 , C08F220/06
摘要： Polymer hydrogels are adapted for surgical implants by chemical modification of the surface to stimulate the attachment and growth of cells thereto. The modification may be by oxidative acid etching or by copolymerisation with methacrylic acid and diethylaminoethyl methacrylate.
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