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1.发明公开ePTFE SMALL CALIBER VASCULAR GRAFTS WITH SIGNIFICANT PATENCY ENHANCEMENT VIA A SURFACE COATING WHICH CONTAINS COVALENTLY BONDED HEPARIN 失效小口径人工血管由ePTFE具有一致性，改善加速通过表面涂层共价结合的肝素，
公开(公告)号：EP0929325A1
公开(公告)日：1999-07-21
申请号：EP97941549.0
申请日：1997-09-11
CPC分类号： A61L27/34 , A61L27/507 , A61L33/0029 , A61L33/0047 , A61L33/0094
摘要： Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced patency are disclosed. Methods of preparing same are also provided.
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公开(公告)号：EP1063943A1
公开(公告)日：2001-01-03
申请号：EP99911446.5
申请日：1999-03-18
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2002/072 , A61F2002/075
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube. The stent provides patency to the endoprosthesis.
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公开(公告)号：EP0941131A1
公开(公告)日：1999-09-15
申请号：EP97942443.0
申请日：1997-09-11
CPC分类号： A61L27/26 , A61L27/20 , A61L27/34 , A61L27/52 , A61L33/0064
摘要： A bioresorbable sealant composition useful for impregnating implantable soft-tissue prostheses includes at least two polysaccharides in combination to form a hydrogel or sol-gel. The sealant compositions may optionally include a bioactive agent and/or be cross-linked subsequent to application of these compositions to the substrate surface.
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公开(公告)号：EP0893976B1
公开(公告)日：2006-05-10
申请号：EP97915924.1
申请日：1997-03-13
发明人： LENTZ, David, J. , POPADIUK, Nick , SCHMITT, Peter , DORMIER, Edward, J. , ZDRAHALA, Richard, J.
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61F2002/072 , A61L27/16 , A61L27/507 , Y10S623/901 , C08L27/18
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
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5.发明授权A METHOD OF PRODUCING A RADIALLY SELF-EXPANDING IMPLANTABLE INTRALUMINAL DEVICE 失效制造方法的自膨胀RADIAL，植入腔内装置
公开(公告)号：EP0668752B1
公开(公告)日：2003-04-02
申请号：EP93922693.2
申请日：1993-09-14
CPC分类号： A61F2/90 , A61F2/07 , A61F2/89 , A61F2002/075 , A61F2002/077 , A61F2002/30065 , A61F2002/3008 , A61F2002/30461 , A61F2002/9534 , A61F2210/0071 , A61F2220/0025 , A61F2220/0075 , A61F2250/0098 , D04C1/06 , D10B2509/06 , Y10S623/903
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公开(公告)号：EP0668752A1
公开(公告)日：1995-08-30
申请号：EP93922693.0
申请日：1993-09-14
CPC分类号： A61F2/90 , A61F2/07 , A61F2/89 , A61F2002/075 , A61F2002/077 , A61F2002/30065 , A61F2002/3008 , A61F2002/30461 , A61F2002/9534 , A61F2210/0071 , A61F2220/0025 , A61F2220/0075 , A61F2250/0098 , D04C1/06 , D10B2509/06 , Y10S623/903
摘要： A radially self-expanding implantable intraluminal device (10) formed from a hollow tubular braid. The intra-luminal device may be used in a variety of medical procedures which require a passageway to be maintained in an open position or which require reinforcement, support or a bypass conduit such as in blood vessels weakened by disease. The intra-luminal device is longitudinally expanded or radially collapsed for ease of insertion into a lumen and upon alignment within the lumen, the intra-luminal device (10) radially self-expands to come into intimate contact with the inner surface of the lumen.
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公开(公告)号：EP0702620B1
公开(公告)日：2000-10-11
申请号：EP95913639.1
申请日：1995-03-09
CPC分类号： B29C47/86 , A61L29/041 , B29C47/0004 , B29C47/0016 , B29C47/0023 , B29C47/24 , B29C47/862 , B29C47/864 , B29C47/866 , B29K2027/18 , B29L2031/753 , C08L27/18
摘要： An improved method is provided for extruding ePTFE tube (12) for use in medical applications. A tube (12) of PTFE is extruded, preferably in an extrusion process, using counter-rotated die components (22, 26). The die component (16) is maintained at a constant temperature during processing. The resulting green tube (12) has enhanced fibrous state formation in a direction perpendicular to the direction of extrusion. The PTFE green tube (12) is then subjected to secondary operations such as stretching and expansion to yield medical product. The ePTFE tube (12) structure is defined by nodes interconnected by elongate fibrils. Both the nodes and fibrils are substantially randomly tilted with respect to the longitudinal axis of the tube (12). This particular structure yields a tube (12) which exhibits a high degree of radial tear strength useful in medical applications.
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公开(公告)号：EP0893976A1
公开(公告)日：1999-02-03
申请号：EP97915924.0
申请日：1997-03-13
发明人： LENTZ, David, J. , POPADIUK, Nick , SCHMITT, Peter , DORMIER, Edward, J. , ZDRAHALA, Richard, J.
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61F2002/072 , A61L27/16 , A61L27/507 , Y10S623/901 , C08L27/18
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
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公开(公告)号：EP0879029A1
公开(公告)日：1998-11-25
申请号：EP97904915.0
申请日：1997-01-22
CPC分类号： A61L27/56 , A61F2/06 , A61F2002/0086 , A61F2002/072 , A61L27/16 , A61L27/507 , Y10S623/901 , C08L27/18
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.
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公开(公告)号：EP0702620A1
公开(公告)日：1996-03-27
申请号：EP95913639.0
申请日：1995-03-09
CPC分类号： B29C47/86 , A61L29/041 , B29C47/0004 , B29C47/0016 , B29C47/0023 , B29C47/24 , B29C47/862 , B29C47/864 , B29C47/866 , B29K2027/18 , B29L2031/753 , C08L27/18
摘要： An improved method is provided for extruding ePTFE tube (12) for use in medical applications. A tube (12) of PTFE is extruded, preferably in an extrusion process, using counter-rotated die components (22, 26). The die component (16) is maintained at a constant temperature during processing. The resulting green tube (12) has enhanced fibrous state formation in a direction perpendicular to the direction of extrusion. The PTFE green tube (12) is then subjected to secondary operations such as stretching and expansion to yield medical product. The ePTFE tube (12) structure is defined by nodes interconnected by elongate fibrils. Both the nodes and fibrils are substantially randomly tilted with respect to the longitudinal axis of the tube (12). This particular structure yields a tube (12) which exhibits a high degree of radial tear strength useful in medical applications.
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