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公开(公告)号：EP1199104B1
公开(公告)日：2010-01-27
申请号：EP01123563.7
申请日：2001-10-01
CPC分类号： B01L3/5082 , A61B5/15003 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61L33/0064 , A61L33/064 , C08L39/06
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公开(公告)号：EP2683420B1
公开(公告)日：2018-05-23
申请号：EP12708138.8
申请日：2012-03-09
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
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公开(公告)号：EP0258317A1
公开(公告)日：1988-03-09
申请号：EP87901283.0
申请日：1987-02-17
CPC分类号： C08F265/04 , A61L33/0064 , A61L33/0082 , A61L33/0088 , Y10S623/924 , Y10T428/24479 , A61L33/064 , C08L33/14 , A61L27/16 , A61L27/52 , A61F2/06 , C08F220/34 , C08F220/06
摘要： Les hydrogels polymères ci-décrits sont conçus pour faire l'objet d'implants chirurgicaux par modification chimique de leur surface, afin de stimuler la fixation et la croissance des cellules. Ladite modification peut se faire par attaque à l'acide oxydant ou par copolymérisation avec de l'acide métacrylique et du métacrylate de diéthylaminoéthyle.
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公开(公告)号：EP2999494A4
公开(公告)日：2017-01-18
申请号：EP14800261
申请日：2014-05-19
申请人： UNIV YALE
IPC分类号： A61L31/08
CPC分类号： A61L27/507 , A61K31/727 , A61K35/44 , A61L27/34 , A61L27/3625 , A61L27/52 , A61L27/54 , A61L33/0011 , A61L33/0029 , A61L33/0064 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2420/02 , A61L2420/08 , A61L2430/40 , B05D7/54 , C08L5/08
摘要： The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an anti-thrombogenic coating. The present invention also provides methods of preparing anti-thrombogenic compositions and methods of treatment comprising implanting the anti-thrombogenic compositions into a subject in need thereof.
摘要翻译： 本发明提供抗血栓形成组合物，包括抗血栓形成血管移植物。 在某些实施方案中，组合物包含涂有抗血栓形成包衣的脱细胞组织。 本发明还提供了制备抗血栓形成组合物和治疗方法的方法，包括将抗血栓形成组合物植入有需要的受试者。
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5.发明公开Medical article having blood-contacting surface 有权Medizinischer Gegenstand mit blutkontaktierenderOberfläche
公开(公告)号：EP1199104A2
公开(公告)日：2002-04-24
申请号：EP01123563.7
申请日：2001-10-01
CPC分类号： B01L3/5082 , A61B5/15003 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61L33/0064 , A61L33/064 , C08L39/06
摘要： A plastic medical article, such as a catheter or blood collection tube, is coated with a crosslinked hydrogel permanently bound to the inside wall of the tube. The hydrophilic surface provided by the hydrogel prevents adherence of blood components to the surface, and the permanent adherence of the hydrogel prevents its removal by blood.
摘要翻译： 诸如导管或采血管的塑料医疗制品涂覆有永久地结合到管的内壁的交联水凝胶。 由水凝胶提供的亲水性表面防止血液成分粘附到表面，并且水凝胶的永久性粘附防止其被血液除去。
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公开(公告)号：EP0941131A1
公开(公告)日：1999-09-15
申请号：EP97942443.0
申请日：1997-09-11
CPC分类号： A61L27/26 , A61L27/20 , A61L27/34 , A61L27/52 , A61L33/0064
摘要： A bioresorbable sealant composition useful for impregnating implantable soft-tissue prostheses includes at least two polysaccharides in combination to form a hydrogel or sol-gel. The sealant compositions may optionally include a bioactive agent and/or be cross-linked subsequent to application of these compositions to the substrate surface.
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7.发明授权
公开(公告)号：EP2083946B1
公开(公告)日：2015-04-08
申请号：EP07824588.3
申请日：2007-11-19
申请人： The University Court of the University of St. Andrews , The University Court Of The University of Edinburgh
IPC分类号： A61K8/19 , A61K8/26 , A61K33/00 , A61K33/06 , A61K33/34 , A61K45/06 , A61L15/44 , A61L29/16 , A61L31/16 , A61Q19/00 , B01J20/06 , B01J20/02 , B01J20/18 , B01J29/072 , B01J29/46 , B01J29/14
CPC分类号： B01J29/072 , A01N25/08 , A01N25/26 , A01N59/00 , A61K8/19 , A61K8/26 , A61K9/143 , A61K33/00 , A61K33/06 , A61K33/34 , A61K45/06 , A61K47/02 , A61L15/44 , A61L27/20 , A61L27/34 , A61L27/507 , A61L27/52 , A61L29/16 , A61L31/16 , A61L33/0011 , A61L33/0064 , A61L2300/114 , A61Q19/00 , B01J20/02 , B01J20/0237 , B01J20/0281 , B01J20/0288 , B01J20/06 , B01J20/18 , B01J20/186 , B01J20/3234 , B01J23/72 , B01J29/143 , B01J29/46 , B01J2220/42 , Y02A50/409
摘要： The present invention relates to a bifunctional material which comprises copper and which is capable of storing nitric oxide (NO), as well as catalytically producing nitric oxide from a suitable precursor. The material typically includes a zeolite and the copper may be part of, or separate from the zeolite. In this manner the material may include a single bifunctional material; that is, a material which is capable of both storing NO and catalytically producing NO, such as Cu-MFI or Cu-X. Alternatively the material may include at least two components, a first component to store NO, such as a zeolite Zn-LTA, and a further component including Cu(I), such as Cu2O, to catalytically produce NO from a suitable precursor. The bifunctional material may be used in a pharmaceutical, neutraceutical or cosmetic preparation, or comprised in a medical article, a cosmetic and/or personal hygiene product.
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8.发明公开IMPROVEMENTS TO IMMOBILISED BIOLOGICAL ENTITIES 有权VERBESSERUNGEN AN IMMOBILISITENTEN BIOLOGISCHEN EINHEITEN
公开(公告)号：EP2683420A1
公开(公告)日：2014-01-15
申请号：EP12708138.8
申请日：2012-03-09
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
摘要翻译： 特别地描述了具有包括层状涂层的表面的装置，其中外涂层包含多个阳离子超支化聚合物分子，其特征在于具有（i）分子量为14-1,000Da的核心部分（ii）总分子量 （iii）总分子量与核心部分分子量的比例为至少80:1，和（iv）官能端基，其中一个或多个所述官能端基具有共价连接的抗凝剂实体 于此。
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公开(公告)号：EP1401511A2
公开(公告)日：2004-03-31
申请号：EP02751298.7
申请日：2002-06-26
申请人： Biointeractions Ltd
CPC分类号： C08B37/0075 , A61L27/20 , A61L27/34 , A61L27/507 , A61L27/52 , A61L33/0011 , A61L33/0064 , C08B37/0063 , C08B37/0069 , Y10S514/822 , Y10S514/944 , Y10S514/953 , C08L39/06
摘要： The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein.
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10.发明公开Blood gas syringe having improved blood barrier 审中-公开Spritze zur Gewinnung von Gasen im Blut，mit verbesserter Blutsperre
公开(公告)号：EP1287784A1
公开(公告)日：2003-03-05
申请号：EP02018947.8
申请日：2002-08-26
CPC分类号： A61L33/0064 , A61B5/15003 , A61B5/150213 , A61B5/150244 , A61B5/150274 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61L31/145
摘要： A blood gas syringe includes a porous plastic plug having a crosslinked hydrogel affixed to a wall of a passageway of the plug. When a blood sample is taken with the syringe, the incoming sample forces air in the system out through the passageway of the plug until the sample contacts the hydrogel, causing the passageway to seal shut.
摘要翻译： 血气注射器包括多孔塑料塞，其具有固定到塞子的通道的壁上的交联水凝胶。 当使用注射器取样血样时，进样将迫使系统中的空气通过塞子的通道流出，直到样品与水凝胶接触，导致通道密封。
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