公开(公告)号：EP4093727B1

公开(公告)日：2024-07-31

申请号：EP21701697.1

申请日：2021-01-20

IPC分类号： C07C251/20 ,  A61K8/41 ,  A61P17/16

CPC分类号： C07C251/20 ,  C07C2601/1620170501 ,  A61K8/41 ,  A61P17/16 ,  A61Q19/00 ,  A61Q17/04 ,  A61K2800/52220130101 ,  A61K2800/1020130101

公开(公告)号：EP4389214A2

公开(公告)日：2024-06-26

申请号：EP24174263.4

申请日：2018-09-28

申请人： Thorel, Jean-Noël

发明人： Thorel, Jean-Noël

IPC分类号： A61P17/16

CPC分类号： A61K8/37 ,  A61K8/496 ,  A61K8/4966 ,  A61Q17/04 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/216 ,  A61K2800/52220130101 ,  A61P17/16

摘要： La présente invention concerne l'utilisation du trimethoxybenzyl acetylsinapate, avantageusement en combinaison avec au moins un filtre solaire, pour la protection de la peau.

公开(公告)号：EP4385998A1

公开(公告)日：2024-06-19

申请号：EP22848550.4

申请日：2022-07-27

申请人： Hangzhou Huibo Science and Technology Co., Ltd

发明人： WU, Gang ,  LU, Yunyu ,  WU, Liyong ,  CHENG, Liuxingxing ,  LEI, Xiaoxuan

IPC分类号： C07K14/00 ,  C07K7/56 ,  C07K7/08 ,  C07K7/06 ,  C07K1/04 ,  C07K1/107 ,  C07K1/34 ,  C07K1/14 ,  A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  A61P17/02 ,  A61P17/16

CPC分类号： A61K38/10 ,  A61K38/16 ,  A61K38/08 ,  A61P17/02 ,  A61P17/16 ,  C07K1/04 ,  C07K1/14 ,  C07K1/107 ,  C07K1/34 ,  C07K7/06 ,  C07K7/08 ,  C07K7/56 ,  C07K14/00

摘要： The present invention provides a cyclic peptide, and a preparation method and use thereof. The cyclic peptide is a series of head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides with triazole rings, which are prepared by an azido-alkyne cycloaddition reaction of the whole sequence of linear histamine or the truncated sequence of a linear Hst1 under specific conditions; where the biological activity of the full-sequence head-to-tail cyclic peptide or N-terminal and C-terminal cyclized peptide is increased by more than 1,000 times compared with that of the linear histamine, can significantly improve a dose-effect ratio and clinical efficacy of the histamine over the existing histamine cyclic peptide; the head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides of the truncated sequence of the Hst1 has a molecular weight which is only 1/3 of that of the linear Hst1, biological activity that is 15 times that of the linear Hst1, and the cost for achieving the same activity that is only 1/100 of that of the linear Hst1. The entire cyclization process is gentle, simple, convenient and efficient, and can produce high-purity head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides, can be used for preparing anti-aging and repairing skin care products, health care products, or medicines, and has a very good prospect for large-scale industrialization.

公开(公告)号：EP4041186B1

公开(公告)日：2024-05-22

申请号：EP20789063.3

申请日：2020-10-07

IPC分类号： A61P17/16 ,  A61K9/00 ,  A61K9/12 ,  A61K31/18 ,  A61K31/573 ,  A61K31/593

CPC分类号： A61K31/593 ,  A61K31/573 ,  A61K9/122 ,  A61K9/0014 ,  A61P17/16 ,  A61K31/18 ,  A61K47/06

公开(公告)号：EP4353325A1

公开(公告)日：2024-04-17

申请号：EP22820066.3

申请日：2022-05-26

申请人： Shiseido Company, Ltd.

发明人： IWAMI, Shiho

IPC分类号： A61P43/00 ,  A61P17/16 ,  A61Q19/08 ,  A61K9/107 ,  A61K8/06 ,  A61K8/27 ,  A61K8/29 ,  A61K8/49 ,  A61K8/86 ,  A61K47/34 ,  A61K33/06 ,  A61K33/30 ,  A61K31/4025

CPC分类号： A61P43/00 ,  A61K31/4025 ,  A61K9/107 ,  A61K8/86 ,  A61K47/34 ,  A61Q19/08 ,  A61K8/49 ,  A61K8/27 ,  A61K8/06 ,  A61K33/06 ,  A61K8/29 ,  A61P17/16 ,  A61K33/30

摘要： To provide a novel external skin composition suitable for cell activation.
A external skin composition of the present disclosure contains a UV wavelength conversion substance and an alkylene oxide derivative.

公开(公告)号：EP3352725A1

公开(公告)日：2018-08-01

申请号：EP16849861.6

申请日：2016-09-26

申请人： Deckner Consulting Services, LLC

发明人： DECKNER, George, Endel ,  HUSS, Nickolas

IPC分类号： A61K8/18 ,  A61K8/00 ,  A61Q17/04

CPC分类号： A61K8/062 ,  A61K8/0241 ,  A61K8/042 ,  A61K8/06 ,  A61K8/25 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/415 ,  A61K8/4966 ,  A61K8/8152 ,  A61K8/8182 ,  A61K2800/21 ,  A61K2800/30 ,  A61K2800/412 ,  A61P17/16 ,  A61Q17/04

摘要： Disclosed herein are oil-in-water dispersions and sunscreen compositions that contain them, which exhibit high in vivo sun protection factor (SPF) efficiency due to the ability of the dispersions to both absorb and scatter ultraviolet (UV) light. These high efficiency sunscreen compositions include discrete oil particles that are enclosed within a solid coating and dispersed in an aqueous phase, wherein each oil particle contains an organic ultraviolet A (UVA) and/or an organic ultraviolet B (UVB) absorbing compound, and optionally a photo stabilizer.

公开(公告)号：EP3279212A1

公开(公告)日：2018-02-07

申请号：EP16773502.6

申请日：2016-04-01

申请人： Stemmedicare Co., Ltd.

发明人： LEE, Jang Ho

IPC分类号： C07K14/435 ,  C12N5/00 ,  C12N5/0775 ,  C07K14/47 ,  C07K14/475 ,  C07K14/50 ,  C07K14/525 ,  C07K14/54 ,  C07K14/78 ,  A61K35/28

CPC分类号： A61K35/28 ,  A61K9/0014 ,  A61K38/39 ,  A61P17/16 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/49 ,  C07K14/50 ,  C07K14/525 ,  C07K14/54 ,  C07K14/5409 ,  C07K14/545 ,  C07K14/78 ,  C12N5/00 ,  C12N5/0031

摘要： The present invention relates to the method for mass production of mesenchymal stem cell-derived proteins including various growth factors and cytokines, a mesenchymal stem cell conditioned medium containing a large amount of protein and produced by the above production method, cosmetic composition and pharmaceutical composition including the above conditioned medium for skin regeneration, anti-wrinkle, alopecia treatment, prevention of hair loss and promotion of hair growth.
The method for mass production of the mesenchymal stem cell-derived protein of the present invention can greatly increase the amount of various growth factors and proteins which are known to be not expressed from mesenchymal stem cells or expressed only in very small amounts by the existing culture method, and the mesenchymal stem cell conditioned medium prepared by the above method contains a large amount of various kinds of cytokines and growth factors so that it has the excellent effect on skin regeneration, wrinkle improvement, prevention of hair loss, alopecia treatment and hair growth promotion.

摘要翻译： 本发明涉及大量生产包括各种生长因子和细胞因子的间充质干细胞衍生的蛋白质的方法，含有大量蛋白质并通过上述生产方法生产的间充质干细胞条件培养基，化妆品组合物和药物组合物，包括 上述用于皮肤再生，抗皱纹，脱发治疗，防止脱发和促进毛发生长的条件培养基。 批量生产本发明的间充质干细胞衍生蛋白质的方法可以大大增加已知不从间充质干细胞表达的或通过现有培养物仅以非常少的量表达的各种生长因子和蛋白质的量 方法，并且通过上述方法制备的间充质干细胞条件培养基含有大量的各种细胞因子和生长因子，因此它对皮肤再生，皱纹改善，防止脱发，脱发治疗和毛发生长具有优异的效果 推广。

公开(公告)号：EP4417200A1

公开(公告)日：2024-08-21

申请号：EP22881017.2

申请日：2022-10-11

申请人： Kao Corporation

发明人： SAYAMA, Keimon ,  FUKAGAWA, Satoko ,  ISHIKAWA, Junko ,  SASAKI, Aya

IPC分类号： A61K31/202 ,  A23D9/00 ,  A23L33/115 ,  A61K31/232 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/10 ,  A61P17/16

CPC分类号： A61P17/00 ,  A61P29/00 ,  A61P17/10 ,  A23L33/115 ,  A61K31/202 ,  A23L5/00 ,  A61P17/08 ,  A61P37/08 ,  A61P17/06 ,  A61P17/16 ,  A23D9/00 ,  A61K31/232

摘要： Provided is an agent for preventing, treating, or improving inflammatory skin disease. An agent for preventing, treating, or improving inflammatory skin disease comprising, as an active ingredient, a fat or oil in which a content of α-linolenic acid in fatty acids constituting the fat or oil is 40 mass% or more, and a content of diacylglycerol is 25 mass% or more.

公开(公告)号：EP4401748A1

公开(公告)日：2024-07-24

申请号：EP22789475.5

申请日：2022-09-09

申请人： BASF SE

发明人： MACK, Sandra ,  GRAHAM, David ,  WEISSENEGGER, Markus ,  FALKOWSKI, Jürgen ,  ZIMNY, Antje

IPC分类号： A61K36/55 ,  A61K8/00 ,  A61K9/00

CPC分类号： A61K36/55 ,  A61K2236/0020130101 ,  A61P17/16 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q17/04 ,  A61K2800/80520130101 ,  A61K8/9789

公开(公告)号：EP2384191B1

公开(公告)日：2018-07-18

申请号：EP09764756.4

申请日：2009-11-10

申请人： Giuliani S.p.A.

发明人： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  BARONI, Sergio

IPC分类号： A61K31/045 ,  A61K31/11 ,  A61K31/22 ,  A61K31/202 ,  A61K31/231 ,  A61K31/232 ,  A61P17/16 ,  A61P17/10 ,  A61P17/00 ,  A61K8/36 ,  A61K8/37 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q17/04

CPC分类号： A61K31/045 ,  A61K8/342 ,  A61K8/361 ,  A61K8/37 ,  A61K31/11 ,  A61K31/202 ,  A61K31/22 ,  A61K31/23 ,  A61K31/231 ,  A61K31/232 ,  A61P17/00 ,  A61P17/10 ,  A61P17/16 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

摘要： The present invention relates to a novel use of compounds having the general formula (I): CH3(—CH═CH)n—R  (I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R′, CO—OR′, CO—O(−), where R′ is chosen from among H, the alkyl from C1 to C22, each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.