ISOTHIOCYANATE COMPOSITION
    11.
    发明公开
    ISOTHIOCYANATE COMPOSITION 有权
    异硫氰酸盐组合物

    公开(公告)号:EP3214071A1

    公开(公告)日:2017-09-06

    申请号:EP17159930.1

    申请日:2014-02-28

    Abstract: The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

    Abstract translation: 本发明涉及以有机伯胺和硫脲为原料的异硫氰酸酯的制造方法, 涉及用于运输和储存包含N-取代的O-取代的硫代氨基甲酸酯和羟基化合物的N-取代的O-取代的硫代氨基甲酸酯的组合物,羟基化合物的羟基相对于N的氨基甲酸酯基团的当量重量比 - 取代的O-取代的硫代氨基甲酸酯在1至100范围内; 涉及一种用于输送和储存具有硫脲基的化合物和硫脲基的化合物的组合物,所述化合物包含具有硫脲基的化合物和羟基化合物,羟基化合物的羟基相对于具有硫脲基的化合物的硫脲基的当量重量比 在1到100的范围内; 并且涉及含有异硫氰酸酯和具有特定官能团的化合物的异硫氰酸酯组合物。

    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES
    12.
    发明公开
    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES 审中-公开
    新型绿色和橙色荧光标记和用途

    公开(公告)号:EP1546673A2

    公开(公告)日:2005-06-29

    申请号:EP03754878.1

    申请日:2003-09-23

    Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.

    VERFAHREN ZUR HERSTELLUNG VON 2-CHLOR-5-CHLORMETHYL-1,3-THIAZOL
    13.
    发明授权
    VERFAHREN ZUR HERSTELLUNG VON 2-CHLOR-5-CHLORMETHYL-1,3-THIAZOL 有权
    PROCESS FOR 2-氯-5-甲基-1,3-噻唑氯制备

    公开(公告)号:EP1230229B1

    公开(公告)日:2003-05-28

    申请号:EP00967893.9

    申请日:2000-10-20

    CPC classification number: C07C331/20 C07D277/32 C07D277/40 Y02P20/55

    Abstract: The invention relates to a method for producing 2-chloro-5-chloromethyl-1,3-thiazol from compounds of formula (I), wherein X means Cl, -OR, -SR or NR2, R being H or a suitable protective group; Y means H or Cl and Z means Cl or O, the compounds of formula (I) having at most one double bond between C* and C' or between C' and Z, on the condition that the bond between C' and Z is a double bond when Z is the same as O and a single bond when Z is the same as Cl; with the following intermediate stage: A1) reacting 2,3-dichloropropanal with rhodanide and acetalising to 3-chloro-1,1-dialkoxy-2-isothiocyanato-propane or a2) reacting 2,3-dichloropropanal with thiourea to form a mixture of the hydrochlorides of the compounds N-[[5-(2-aminothiazol)yl]methyl] thiourea and [5-(2-aminothiazol)yl]methylthioformamidine and splitting to obtain the corresponding thiol or amine or b) reacting a compound of formula (I) wherein X means OR, SR or NR2, Y means chlorine and Z means oxygen with thiourea to produce the compound of formula (V), or c) reacting a compound of formula (I), wherein X means OR, SR or NR2, Y means chlorine and Z means oxygen with ammoniumdithiocarbamate or ammoniumthiocarbamate, to produce the compound (VIa) or (VIb); d) converting 1,2,3-trichloropropane to the corresponding thiazolidine and then dehydrogenating or e) converting 1,3-dichloro-prop-1-ene to the corresponding epoxide and then reacting said epoxide with thiourea (e1) or ammoniumdithiocarbamate or ammoniumthiocarbamate (e2).

    Sulfur containing fluoroalkyl amines and isocyanates
    19.
    发明公开
    Sulfur containing fluoroalkyl amines and isocyanates 审中-公开
    氟烷基胺和异氰酸酯

    公开(公告)号:EP2662354A2

    公开(公告)日:2013-11-13

    申请号:EP13179255.8

    申请日:2008-12-01

    Abstract: The present invention provides sulfur containing fluoroalkyl amines represented by the formula Rf-Q-S(O) x -C(H) i (CH 3 ) j -(CH 2 ) z+(i-1) -NHR and isocyanate/isothiocyanate derivatives thereof represented by the formula Rf-Q-S(O) x -C(H) i (CH 3 ) j -(CH 2 ) z+(i-1) -N=C=X 1 wherein R f is chosen from a C 2 -C 12 perfluoroalkyl provided that: i) one fluorine atom of the perfluoroalkyl can be optionally replaced by hydrogen, and/or ii) the perfluoro-alkyl can be optionally interrupted by at least one oxygen, methylene, or ethylene; Q is chosen from the group consisting of a C 2 -C 12 hydrocarbylene optionally interrupted by at least one divalent organic group; x is 1 or 2; z is 0 or 1; i is 1 or 2; j is 0 or 1; provided that i+j=2; R is chosen from H or a C 1 to C 4 alkyl; and X 1 is O or S.

    Abstract translation: 本发明提供由式Rf-QS(O)x -C(H)i(CH 3)j - (CH 2)z +(i-1)-NHR表示的含硫氟烷基胺及其异氰酸酯/异硫氰酸酯衍生物 通过式Rf-QS(O)x -C(H)i(CH 3)j - (CH 2)z +(i-1)-N = C = X 1其中R f选自C 2 -C 12全氟烷基,条件是:i)全氟烷基中的一个氟原子可任选被氢替代,和/或ii)全氟烷基可以任选被至少一个氧,亚甲基或亚乙基所取代; Q选自任选被至少一个二价有机基团间隔的C 2 -C 12亚烃基; x为1或2; z为0或1; 我是1或2; j为0或1; 条件是i + j = 2; R选自H或C 1至C 4烷基; X 1为O或S.

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