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公开(公告)号：EP4342529A3
公开(公告)日：2024-10-09
申请号：EP23205683.8
申请日：2016-12-16
发明人： SAMPEI, Zenjiro
IPC分类号： C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , A61P7/00 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/50520130101 , C07K2299/0020130101 , C07K2317/2420130101 , C07K2317/3020130101 , C07K2317/3320130101 , C07K2317/5520130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2317/9420130101 , C07K2317/3420130101 , A61P7/00
摘要： The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the beta chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the beta chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.
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公开(公告)号：EP4373854A1
公开(公告)日：2024-05-29
申请号：EP22754735.3
申请日：2022-07-19
申请人： Inhibrx, Inc.
IPC分类号： C07K16/28 , C07K14/55 , A61P35/00 , A61K39/395
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公开(公告)号：EP4356927A2
公开(公告)日：2024-04-24
申请号：EP23214154.9
申请日：2013-10-15
申请人： Arizona Board of Regents on behalf of Arizona State University , Sierks, Michael , Tian, Huilai , Moe, James G. , Davidowitz, Eliot
IPC分类号： A61K39/395
CPC分类号： G01N2800/282120130101 , C07K16/005 , C07K2317/2120130101 , C07K2317/3020130101 , C07K2317/62220130101 , C07K16/18 , C12N15/1037 , G01N33/6896 , A61P25/28
摘要： The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or nondisease associated forms of tau.
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公开(公告)号：EP4442709A2
公开(公告)日：2024-10-09
申请号：EP24191393.8
申请日：2018-01-17
申请人： Ablynx NV
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K2317/2220130101 , C07K2317/3020130101 , C07K2317/3320130101 , C07K2317/56920130101 , C07K2317/9220130101
摘要： The present invention relates to amino acid sequences that can bind to serum albumin.
In particular, the present invention relates to immunoglobulin single variable domains, and in particular heavy-chain immunoglobulin single variable domains, that can bind to serum albumin.
The invention also relates to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise at least one of the immunoglobulin single variable domains binding to serum albumin that are described herein.-
公开(公告)号：EP4426438A1
公开(公告)日：2024-09-11
申请号：EP22800371.1
申请日：2022-10-28
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公开(公告)号：EP4423131A1
公开(公告)日：2024-09-04
申请号：EP22812470.7
申请日：2022-10-25
申请人： Granite Bio AG
发明人： MACK, Matthias
IPC分类号： C07K16/28
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公开(公告)号：EP3166688B1
公开(公告)日：2024-08-21
申请号：EP15818480.4
申请日：2015-07-06
CPC分类号： G01N2800/282120130101 , C07K16/18 , C07K2317/3020130101 , C07K2317/62220130101 , A61K38/00 , G01N33/6896 , A61P21/02 , A61P25/00 , A61P25/16 , A61P25/28
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公开(公告)号：EP4408893A1
公开(公告)日：2024-08-07
申请号：EP22874016.3
申请日：2022-09-28
发明人： HOU, Wenyang , YAO, Shugang , DA CRUZ, Luis , YOUNG, David S.
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公开(公告)号：EP4335874A3
公开(公告)日：2024-05-29
申请号：EP23211486.8
申请日：2017-11-16
发明人： DENGL, Stefan , FISCHER, Jens , KIRSTENPFAD, Claudia , KLOSTERMANN, Stefan , KOENIGSBERGER, Esther , MAJETY, Meher , ROS, Francesca , TIEFENTHALER, Georg
IPC分类号： C07K16/28
CPC分类号： C07K14/70539 , C07K16/2833 , C07K2317/3020130101 , C07K2317/3320130101 , C07K2317/7620130101 , C07K2317/9220130101 , A61P35/00
摘要： The present invention relates to anti-HLA-G antibodies and methods of using the same.
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