公开(公告)号：EP1759001A1

公开(公告)日：2007-03-07

申请号：EP05739065.0

申请日：2005-04-21

申请人： Enobia Pharma Inc.

发明人： CRINE, Philippe ,  BOILEAU, Guy ,  LEMIRE, Isabelle ,  LOISEL, Thomas, P.

IPC分类号： C12N15/57 ,  A61K38/46 ,  A61K38/48 ,  A61K47/48 ,  C12N15/55 ,  C12N9/50 ,  C12N9/14 ,  A61P19/08 ,  G01N33/68

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/645 ,  C07K14/51 ,  C07K2319/01 ,  C07K2319/23 ,  C12N9/16 ,  C12N9/6421 ,  C12N9/6494 ,  C12Y301/03001 ,  C12Y304/24011

摘要： A bone delivery conjugate having a structure selected from the group consisting of :A) X-D n -Y-protein-Z; and B) Z-protein-Y- D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n = 10 to 16. Compositions comprising same and uses thereof.

公开(公告)号：EP0272928A3

公开(公告)日：1990-04-04

申请号：EP87311365.8

申请日：1987-12-23

申请人： GENENTECH, INC.

发明人： Malfroy-Camine, Bernard ,  Schofield, Peter R.

IPC分类号： C12N15/00 ,  C12N9/64 ,  G01N33/573 ,  C12N5/00

CPC分类号： C12N9/6494 ,  A61K38/00 ,  C12Q1/37 ,  C12Y304/24011 ,  G01N33/573 ,  G01N2333/96486

摘要： DNA isolates coding for enkephalinase and methods of obtaining such DNA are provided, together with expression systems for recombinant production of enkephalinase for use in therapeutic or diagnostic compositions. Enkephalinase assays are facilitated by novel enkephalinase substrates.

公开(公告)号：EP0272929A2

公开(公告)日：1988-06-29

申请号：EP87311366.6

申请日：1987-12-23

申请人： GENENTECH, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Malfroy-Camine ,  Nadel, Jay A. ,  Borson, Daniel B.

IPC分类号： A61K38/46

CPC分类号： C12N9/6494 ,  A61K38/00 ,  C12Y304/24011 ,  G01N2333/96486

摘要： A method and therapeutic composition for the treatment of pathological disorders associated with endogenous peptides by the administration of enkephalinase or derivatives thereof.

摘要翻译： 通过给予脑啡肽酶或其衍生物来治疗与内源性肽相关的病理学障碍的方法和治疗组合物。

公开(公告)号：EP2348114B1

公开(公告)日：2018-07-25

申请号：EP11000196.3

申请日：2005-04-21

申请人： Alexion Pharmaceuticals, Inc.

发明人： Crine, Philippe ,  Boileau, Guy ,  Lemire, Isabelle ,  Loisel, Thomas P.

IPC分类号： C12N15/62 ,  A61K38/46 ,  C12N9/16 ,  A61P19/08

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/645 ,  C07K14/51 ,  C07K2319/01 ,  C07K2319/23 ,  C12N9/16 ,  C12N9/6421 ,  C12N9/6494 ,  C12Y301/03001 ,  C12Y304/24011

摘要： A bone delivery conjugate having a structure selected from the group consisting of :A) X-D n -Y-protein-Z; and B) Z-protein-Y- D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n = 10 to 16. Compositions comprising same and uses thereof.

公开(公告)号：EP3027280A1

公开(公告)日：2016-06-08

申请号：EP14747595.8

申请日：2014-07-30

申请人： F. Hoffmann-La Roche AG

发明人： BOHRMANN, Bernd ,  FRESKGARD, Per-Ola ,  KNOETGEN, Hendrik ,  NIEWOEHNER, Jens

IPC分类号： A61P25/28 ,  C07K9/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  C07K14/47

CPC分类号： C07K16/2881 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/60 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/74 ,  C12N9/6494 ,  C12Y304/24011

摘要： The invention relates to a fusion protein comprising an antibody directed to Aβ, a monovalent binding entity which binds to a blood brain barrier receptor and a neprilysin.

摘要翻译： 本发明涉及一种融合蛋白，其包含针对A＆bgr的抗体，结合血脑屏障受体的一价结合实体和尿丙氨酸。

公开(公告)号：EP2351765A3

公开(公告)日：2012-02-22

申请号：EP10185703.5

申请日：2002-07-10

申请人： Lakewood-Amedex, Inc

发明人： Dale, Roderic ,  Arrow, Amy ,  Thompson, Terry

IPC分类号： C07H21/04 ,  A61K48/00 ,  C12N15/00

CPC分类号： C12N15/1137 ,  A61K8/606 ,  A61K38/00 ,  A61K2800/74 ,  A61Q19/00 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2320/35 ,  C12Y101/01088 ,  C12Y103/99005 ,  C12Y111/01006 ,  C12Y113/11012 ,  C12Y114/99001 ,  C12Y203/01026 ,  C12Y203/01085 ,  C12Y301/01003 ,  C12Y301/03048 ,  C12Y304/1401 ,  C12Y304/15001 ,  C12Y304/24011 ,  C12Y306/0301 ,  C12Y604/01002 ,  C12N2310/3521

摘要： The present invention related to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.

公开(公告)号：EP1311691B1

公开(公告)日：2006-10-04

申请号：EP01966885.4

申请日：2001-08-23

申请人： Enobia Pharma Inc.

发明人： BOILEAU, Guy

IPC分类号： C12N15/57 ,  C12N15/62 ,  C12N9/64 ,  C07K16/18 ,  G01N33/68 ,  A61K38/48 ,  A61P19/10

CPC分类号： C12Y304/24011 ,  A61K38/00 ,  C12N9/6494 ,  G01N33/6893 ,  G01N2800/10 ,  G01N2800/108

摘要： The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require osteogenesis. Osteocalcin is an endogenous inhibitor of the PHEX activity. Therefore, the identification of a substance capable of potentiating PHEX activity by preventing the inhibitory action of endogenous inhibitors will improve osteogenesis. Since PHEX is generally associated with the growth plane of bone or teeth and the absence of osteocalcin is associated with increased bone mass, potentiation of PHEX activity can promote bone growth. Increased PHEX activity can also be obtained by administration of the enzyme itself.

公开(公告)号：EP1228095A1

公开(公告)日：2002-08-07

申请号：EP00971185.4

申请日：2000-10-20

申请人： Aventis Pasteur Limited

发明人： BERINSTEIN, Neil ,  TARTAGLIA, James ,  MOINGEON, Philippe ,  BARBER, Brian ,  TINE, John, A.

IPC分类号： C07K14/705 ,  C12N9/64 ,  A61K39/00 ,  C12N5/06 ,  C12N7/00 ,  A61K35/76 ,  A61P35/00 ,  A61K48/00

CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/4748 ,  C12N9/6494 ,  C12N15/86 ,  C12N2710/24043 ,  C12N2710/24071 ,  C12Y304/24011

摘要： A gp100 molecule useful in modulating the immune system is described. In particular what is described is a nucleotide sequence for a gp100 which has been modified so as to be useful in modulating the immune system. The isolated nucleic acid sequence is described and referred to as gp100M. The corresponding protein, referred to as gp100M, is also described. Applications of the molecules as vaccines are described.

公开(公告)号：EP1159412A2

公开(公告)日：2001-12-05

申请号：EP00906114.4

申请日：2000-02-24

申请人： UNIVERSITE DE MONTREAL

发明人： CRINE, Philippe ,  BOILEAU, Guy

IPC分类号： C12N9/64 ,  C12N15/57 ,  C12N5/10 ,  C07K16/40 ,  A61K38/48 ,  A61K48/00 ,  A61K39/395 ,  G01N33/53

CPC分类号： C12N9/6494 ,  A61K38/00 ,  A61K48/00 ,  C12Y304/24011

摘要： This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to endopeptidases on the X chromosome. To produce a soluble form of PHEX, the transmembrane anchor domain has been modified to encode a signal peptidase coding sequence. The soluble PHEX therefore comprises the active ectodomain. An inactive mutant of PHEX is also an object of this invention. Both soluble and inactive mutant forms of PHEX can be used to screen ligands to PHEX. These ligands can also be used as substrates or inhibitors of PHEX. PHEX being phosphaturic, an inhibitor thereof will be used to treat phosphaturia and/or hypophosphatemia. On the opposite, a substrate for PHEX or PHEX itself can be used to treat hyperphosphatemia.

公开(公告)号：EP0272929B1

公开(公告)日：1996-03-20

申请号：EP87311366.6

申请日：1987-12-23

申请人： GENENTECH, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Malfroy-Camine ,  Nadel, Jay A. ,  Borson, Daniel B.

IPC分类号： A61K38/46

CPC分类号： C12N9/6494 ,  A61K38/00 ,  C12Y304/24011 ,  G01N2333/96486