摘要:
This invention is directed to inhibitors of copper-containing amine oxidases (E.C.1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein- 1, VAP-I), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.
摘要:
Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
摘要:
A compound of the formula: wherein, R¹ and R² are the same or different, representing methyl or methoxy groups, or form -CH=CH-CH=CH- by binding to each other; R³ is an aromatic group or a heterocyclic group which may be substituted; and n is an integer of 2 to 8, shows inhibitory effect of cell proliferation and is useful as cell proliferation inhibitor.
摘要翻译:下式化合物:其中R 1和R 2相同或不同,表示甲基或甲氧基,或通过彼此结合形成-CH = CH-CH = CH-; R 3是可以被取代的芳基或杂环基; n为2〜8的整数,表示细胞增殖的抑制效果,可用作细胞增殖抑制剂。
R = Cl,F; R, = H, Cl, F; R 2 and R 5 , which may be the same as or different from each other, are H, halogen, C 1 -C 4 alkyl; R 3 and R 4 , which may be the same as or different from each other, are: H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkenyloxy, haloalkenyloxy or alkynyl; R 6 = H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl; R 7 = C 5 -C 10 monocyclo-, bicyclo- or polycyclo-alkyl or -alkenyl, or C 4 -C 8 monocyclo, bicyclo- or polycyclo-alkyl or -alkenyl containing 1 or 2 heteroatoms such as N, S, O.
The compounds of formula (I) have high acaricide and insecticide activity, in particular against larvae and eggs of acari and insects.
摘要:
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
摘要:
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.