PROCÉDÉ DE FLUORATION DE COMPOSÉS HALOGÉNURES DE SULFONYLE
    17.
    发明公开
    PROCÉDÉ DE FLUORATION DE COMPOSÉS HALOGÉNURES DE SULFONYLE 有权
    VERFAHREN ZUR FLUORIERUNG VON SULFONYL-HALOGENID-VERBINDUNGEN

    公开(公告)号:EP3016933A1

    公开(公告)日:2016-05-11

    申请号:EP14736745.2

    申请日:2014-07-03

    Inventor: METZ, François

    Abstract: The preparation of a compound of formula (I) comprising an -SO
    2 F function by reacting a compound of formula (II) with a fluorinating agent chosen from hydrofluoric acid and an ionic fluoride of a monovalent or divalent cation is described: R-SO
    2 F (I) R'-SO
    2 X (II) where R is chosen from the groups R1, R2 and R3: R1 = -C
    n H
    a F
    b with n=1-10, a+b = 2n+1, b ≥ 1; R2 = -C
    x H
    y F
    z -SO
    2 F with x = 1-10, y+z = 2x and z ≥ 1; R3 = Φ-C
    c H
    h F
    f with c = 1-10; h+f = 2c and f ≥ 1; where R' is chosen from the following groups R'1, R'2 and R'3: R'1 = -C
    n H
    a X
    b with n=1-10, a+b = 2n+1, b ≥ 1; R'2 = -C
    x H
    y X
    z -SO
    2 X with x = 1-10, y+z = 2x and z ≥ 1; R'3 = Φ-C
    c H
    h X
    f with c = 1 -10; h+f = 2c and f ≥ 1; Φ denoting a phenyl group, X = Cl, Br.

    Abstract translation: 描述了通过使式(II)化合物与选自氢氟酸和一价或二价阳离子的离子氟化物的氟化剂反应制备包含-SO 2 F官能团的式(I)化合物:R-SO 2 F(I )R'-SO2X(II)其中R选自R1,R2和R3组:R1 = -CnHaFb,n = 1-10,a + b = 2n + 1,b≥1; R2 = -CxHyFz-SO2F,其中x = 1-10,y + z = 2x和z≥1; R3 =Φ-CcHhFf,其中c = 1-10; h + f = 2c和f≥1; 其中R'选自具有n = 1-10,a + b = 2n + 1,b≥1的以下基团R'1,R'2和R'3:R'1 = -CnHaXb; 其中x = 1-10,y + z = 2x和z≥1的R'2 = -CxHyXz-SO2X; R'3 =Φ-CcHhXf,其中c = 1-10; h + f = 2c和f≥1; Φ表示苯基,X = Cl,Br。

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