wherein R is a C 2-10 non-aromatic hydrocarbyl group optionally substituted by, or a methyl group substituted by cyano, halo, C 1-4 alkoxy optionally substituted by halo, or a group S(O) m R 3 , or R is phenyl optionally substituted by C 1-4 alkoxy, C 1-3 alkyl, C 2 - 4 alkynyl, halo, C 1-4 haloalkyl, cyano or a group S(O) m R 3 ;
R 1 and R 2 may be the same or different, and each is hydrogen, halo, or a C 1 - 3 aliphatic group optionally substituted by halo, cyano, C 1-5 carbalkoxy, C 1-4 alkoxy, or a group S(O) m' R 4 , or R 1 and R and the carbon atoms to which they are attached form a C 5-7 carbocyclic ring optionally substituted by halo, or a C 1-3 aliphatic or alkoxy group; A is a C 5-8 non-aromatic hydrocarbyl group which contains one hetero atom selected from oxygen or sulphur and terminates in a C=C fragment adjacent to X; X is hydrogen; Y and Y1 are the same or different and are each selected from oxygen and S(O) n' and Z is CH 2 0 or CH 2 S-(O)n";
the methods for their preparation, the compositions containing them and their use in the control of pests.
摘要:
Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bi- cyclo-[2,2,3]-nonanes having 2 or 3 ring hetero atoms selected from 0, S and N, substituted at the 1-position by a 4-alkynylphenyl group and at the 4-position and optionally at the 3 and/or 5-position are valuable pesticides, particularly insecticides and acaracides. The compounds may be prepared by reacting an alkyne with the corresponding 4- iodophenyl substituted compound or by debromination of the corresponding 4-dibrom- omethylphenyl substituted compound.
摘要:
Disclosed is a new class of compound which has HSP90 inhibitory activity and is useful as an antitumor agent or the like. Also disclosed is a compound which is useful as a synthesis intermediate for the compound having HSP90 inhibitory activity. Specifically disclosed is a compound represented by the general formula (1) below, or a pharmaceutically acceptable salt thereof. (In the formula, X, R1, R2, R3, R4, R5, R6, R7, L1, L2 and L3 are as defined in the description.)
wherein R is a C 2-10 non-aromatic hydrocarbyl group optionally substituted by, or a methyl group substituted by cyano, halo, C 1-4 alkoxy optionally substituted by halo, or a group S(O) m R 3 , or R is phenyl optionally substituted by C 1-4 alkoxy, C 1-3 alkyl, C 2 - 4 alkynyl, halo, C 1-4 haloalkyl, cyano or a group S(O) m R 3 ; R 1 and R 2 may be the same or different, and each is hydrogen, halo, or a C 1 - 3 aliphatic group optionally substituted by halo, cyano, C 1-5 carbalkoxy, C 1-4 alkoxy, or a group S(O) m' R 4 , or R 1 and R and the carbon atoms to which they are attached form a C 5-7 carbocyclic ring optionally substituted by halo, or a C 1-3 aliphatic or alkoxy group; A is a C 5-8 non-aromatic hydrocarbyl group which contains one hetero atom selected from oxygen or sulphur and terminates in a C=C fragment adjacent to X; X is hydrogen; Y and Y1 are the same or different and are each selected from oxygen and S(O) n' and Z is CH 2 0 or CH 2 S-(O)n"; the methods for their preparation, the compositions containing them and their use in the control of pests.
wherein R b is a C 2-10 non aromatic hydrocarbyl group optionally substituted by cyano, halo, alkoxy, or a group S(O) m bR 3b or R b is phenyl optionally substituted by alkoxy, alkyl, alkynyl, halo, haloalkyl, cyano or a group S(O) m bR 3b as defined hereinbefore; R 1b and R 2b may be the same or different, and each is hydrogen, halo, or a aliphatic group optionally substituted by halo, cyano, carbalkoxy, or alkoxy; a group S(O) m' R 4 and R 4 is alkyl; alkynyl, cyano, gem dimethyl, or carbalkoxy, or R 1b and R b and the carbon atoms to which they are attached form a carbocyclic ring optionally substituted, R 8 , R 9 and R 20 may be the same or different and are selected from chloro, bromo, methoxy or methyl optionally substituted by methoxy or fluoro; B is a single bond, methylene or a C 2-6 aliphatic chain which may contain one or two heteroatoms and/or double bonds but not triple bonds interspersed in the chain and which may be substituted by one to four substituents which may be the same or different and are each independently selected from hydroxy, oxo, halo, alkyl, alkoxy, acyloxy, epoxy, a alkylidene group, a carbalkoxy group, haloalkyl or cyano; D is a single bond or a group CH 2 O, CH 2 S(O) n wherein n is 0, 1 or 2, or D is a 1,2 cyclopropyl group; Y and Y 1 are the same or different and are each selected from oxygen and S(O) n' wherein n' is 0, 1 or 2; and Z is CH 2 CH 2 , CH 2 O or CH 2 S(O) n'' wherein n'' is 0, 1 or 2 provided that B cannot be a single bond or methylene group when D is a single bond, which have pesticidal activity, particularly against anthropod pests.
摘要:
Bicyclo-octane and bicyclo-nonane derivatives are described having herbicidal and plant growth regulating properties. The derivatives are based on the general formula
摘要:
Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bicyclo-[2,2,3]-nonanes, having 2 or 3 ring hetero atoms selected from O, S and N substituted at the 1-position by a carbocyclic group other than an alkynylphenyl group, and substituted at the 4-position and optionally substituted at the 3 and/or 5 position, are valuable pesticides, particularly insecticides and acaracides. Various cyclisation processes are disclosed to form the various bicyclo ring systems.