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    INTEGRATED PLATFORM FOR SINGLE CELL ANALYSIS
    21.
    发明公开
    INTEGRATED PLATFORM FOR SINGLE CELL ANALYSIS 审中-公开

    公开(公告)号：EP3531128A1

    公开(公告)日：2019-08-28

    申请号：EP19158833.4

    申请日：2019-02-22

    申请人： Albert-Ludwigs-Universität Freiburg

    发明人： ZINGGELER, Marc ,  RÜHE, Jürgen ,  BRANDSTETTER, Thomas

    IPC分类号： G01N33/52 ,  G01N33/543

    摘要： The invention relates to a method for analyzing one or more single cells of interest, comprising a) provision of (i) a porous membrane comprising at least one pore, wherein the pore is adjusted to trap a single cell of interest when the cell is applied to the membrane in a liquid medium (ii) a well plate comprising at least one well, wherein the well diameter is larger than the pore diameter and the at least one well contains reagents for analyzing at least one component of the cells of interest, wherein the reagents can be provided in liquid or dry form, (iii) means for assembling the porous membrane and the well plate in an orientation to position the at least one pore opposite of the at least one well, wherein the means for assembling are part of the porous membrane and/or the well plate, (iv) a cover for sealing the at least one well with the at least one pore localized opposite of the at least one well after assembling the porous membrane and the well plate; and b) filtering a liquid cell suspension comprising cells of interest through the porous membrane; c) assembling the porous membrane and the well plate in an orientation to position the at least one pore opposite of the at least one well; d) sealing the at least one well and the at least one pore localized opposite of the well with the cover, and e) analysis of at least one cellular component of a retained single cell in the at least one sealed well.

    PLASMA JET DEVICE
    22.
    发明公开
    PLASMA JET DEVICE 审中-公开

    公开(公告)号：EP3524204A1

    公开(公告)日：2019-08-14

    申请号：EP18155549.1

    申请日：2018-02-07

    申请人： Albert-Ludwigs-Universität Freiburg

    发明人： Ledernez, Loic ,  Bergmann, Michael ,  Engesser, Florian ,  Altenburger, Markus

    IPC分类号： A61C5/50

    摘要： The present invention refers to a plasma jet device (30) for medical treatment of root canals (3) using an atmospheric pressure plasma. The device comprises a handle (40) and a probe (50) with a gas channel (54) and a first and second electrode (31, 32). The probe (50) has a first end connected to the handle (40) and a second end opposite to the first end being a probe tip. The first electrode (31) extends to the probe tip. The first electrode (31) is a hollow outer electrode and the second electrode (32) is an inner electrode extending at least along a section of the first electrode (31) inside the first electrode (31). The second electrode (32) except for a portion at its end is surrounded by a dielectric material (33). The probe (50) is adapted to be inserted into a root canal (3). The plasma jet device (30) is adapted to provide negative pulses at the second electrode (32) for producing the atmospheric pressure plasma at the tip of the second electrode (32). Disclosed is further a method for generating atmospheric pressure plasma.

    Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis
    23.
    发明授权
    Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis 有权

    公开(公告)号：EP2796875B1

    公开(公告)日：2019-03-27

    申请号：EP13164922.0

    申请日：2013-04-23

    申请人： Albert-Ludwigs-Universität Freiburg

    发明人： Shastri, Prasad ,  Christensen, Jon

    IPC分类号： G01N33/574

    摘要： The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.

    CHARGE BALANCING CIRCUIT AND STIMULATOR CIRCUIT
    29.
    发明授权
    CHARGE BALANCING CIRCUIT AND STIMULATOR CIRCUIT 有权
    电荷平衡电路和调节器电路

    公开(公告)号：EP3100766B1

    公开(公告)日：2017-12-27

    申请号：EP15170554.8

    申请日：2015-06-03

    申请人： Albert-Ludwigs-Universität Freiburg

    发明人： Muller, Natalie ,  Kuhl, Matthias ,  Manoli, Yiannos

    IPC分类号： A61N1/37 ,  A61N1/378 ,  A61N1/05 ,  A61N1/02

    CPC分类号： A61N1/3782 ,  A61N1/025 ,  A61N1/05 ,  A61N1/3706

    摘要： A charge balancing circuit (CBC) adapted to be connected to an electrode (E) and to a stimulation source (CS) is provided. The charge balancing circuit (CBC) comprises an electrode terminal (ET) for receiving an electrode voltage (V E ), an amplifier (A) coupled to the electrode terminal (ET) and adapted to amplify and invert the electrode voltage (V E ) for generating an intermediate voltage (V in ) and a compensation stage (CP). The compensation stage (CP) is adapted to generate an output current (I out ) if the electrode voltage (V E ) lies outside a specified safety range and to generate the output current (I out ) depending on the intermediate voltage (V in ). The compensation stage (CP) is further adapted to supply the output current (I out ) to the electrode terminal (ET) for driving the electrode voltage (V E ) towards and/or into the safety range.