公开(公告)号：EP1515960A1

公开(公告)日：2005-03-23

申请号：EP03738697.6

申请日：2003-06-13

申请人： CJ Corporation

发明人： CHO, Il-Hwan ,  LIM, Jee-Woong ,  PARK, Sang-Wook201-1505 Jugong-2Danji ,  RYU, Hyung-Chul601-511 Sanggal Apt. ,  NOH, Ji-YoungRm.503 Byuksangreen Villa ,  KIM, Jong-Hoon503-503 Gongjak Lucky Apt. 1587 ,  CHAE, Myeong-Yun603-402 Ssangyong Apt. ,  JUNG, Sung-Hak ,  PARK, Hyun-Jung102-811 Wooshin Apt. ,  YEON, Kyu-Jeong126-801 Yeonwonmaeul Samhobuksan ,  KANG, Kyoung-RaeRa-403 Youngwoon

IPC分类号： C07D277/36 ,  A61P29/00

CPC分类号： C07D277/36 ,  A61K31/426

摘要： A 2-thioxothiazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

公开(公告)号：EP1391453A1

公开(公告)日：2004-02-25

申请号：EP03018653.0

申请日：2003-08-20

申请人： CJ Corporation

发明人： Youn, Yong Sik ,  Cho, Seong Hwan ,  Park, Choong Sil ,  Kim, Yun Cheul ,  Lim, Dong Kwon ,  Jung, Sung Hak ,  Lee, Sung Hak ,  Kang, Hyun Suk ,  Park, Kyung Mi ,  Jung, Yun Taek ,  Kim, Young Hoon ,  Yeon, Kyu Jeong #126-801 ,  Chae, Myeong Yun ,  Jin, Hae Tak ,  Suh, Hea Ran ,  Lee, Kwang Hyeg ,  Lee, Hyuk Koo

IPC分类号： C07D211/90 ,  A61K31/4422

CPC分类号： C07D211/90

摘要： Disclose is the pyroglutamic acid salt of amlodipine, its preparation and pharmaceutical compositions containing the same as therapeutically active ingredient.

摘要翻译： Disclose是氨氯地平的焦谷氨酸盐，其制剂和含有与治疗活性成分相同的药物组合物。

公开(公告)号：EP1316552A1

公开(公告)日：2003-06-04

申请号：EP02026916.3

申请日：2002-12-03

申请人： CJ Corporation

发明人： Lee, Kwang-hyeg 702-402 Hwangseongvillage, ,  Kim, Jin-wan 101-205 Woojung Apt., 46-5 ,  Choi, Kwang-do ,  Lee, Sang-ho 301-105 Gwanak Seongwon Apt., ,  Cho, Hong-suk Pharm.Research Inst.of Cheil Jedang

IPC分类号： C07D309/30

CPC分类号： C07D309/30

摘要： The present invention relates to a processing method for preparing lovastatin and simvastatin which comprises the steps of (1) performing lactonization of mevinic acid and its homologous compounds in the presence of a mixed organic solvent without an acid catalyst through nitrogen sweep; and (2) making crystals. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced remarkably. Therefore, the processing method of the present invention can be convenient and economical.

摘要翻译： 本发明涉及一种制备洛伐他汀和辛伐他汀的加工方法，该方法包括以下步骤：（1）在没有酸催化剂的混合有机溶剂的存在下，通过氮气吹扫，进行乙酸及其同系化合物的内酯化; 和（2）制造晶体。 在本发明的方法中，可以以高产率制备高度纯化的洛伐他汀和辛伐他汀，特别是作为副产物形成的异二聚体可以显着降低。 因此，本发明的加工方法可以方便和经济。

公开(公告)号：EP1841871A1

公开(公告)日：2007-10-10

申请号：EP05823655.5

申请日：2005-12-30

申请人： CJ Corporation

发明人： PARK, Young Hoon 102-705, Mugigae Maeul Life Apt. ,  KOO, Hyun Min ,  MOON, Jun Ok 101-1403, Deungchon 2-cha Boram Apt. ,  KIM, Seong Jun 307-1001, Poonglim Sinan Apt. ,  KIM, Hyo Jin ,  LEE, Jung Kee

IPC分类号： C12N15/31

CPC分类号： C07K14/34

摘要： Disclosed is a novel L-lysine-inducible promoter nucleic acid molecule. Also disclosed are a vector containing the nucleic acid molecule, a host cell transformed with the vector, and a method of inducing expression of a target gene using the L-lysine-inducible promoter nucleic acid molecule.

公开(公告)号：EP1737430A1

公开(公告)日：2007-01-03

申请号：EP05726255.2

申请日：2005-01-27

申请人： CJ Corporation

发明人： CHO, Cheong-Weon ,  KANG, Kyoung-Rae ,  LEE, Sang-Ho ,  KU, Jeong ,  KIM, Taekrho ,  LEE, Sung-Hak ,  CHOI, Jae-Mook ,  CHEON, Jun-Hee ,  AN, Tae-Kun ,  PARK, Hyun-Jung ,  JEON, Eun-Kyung ,  CHOI, Kwang-Do ,  LIM, Jee-Woong ,  HONG, Kwang-Hee ,  HONG, Hyesuk ,  KIM, Il-Hwan ,  KIM, Tae-Hyoung ,  CHOI, Nak-Hyun ,  KIM, Young-Hoon ,  SUH, Hearan ,  JIN, Hae-Tak ,  YEON, Kyu-Jeong 126-801,Yeonwonmaeul Samho ,  KIM, Jinwan ,  MIN, In-Ki 601-1701 Gahyunmaeul Sinan Apt.,344,

IPC分类号： A61K9/16 ,  A61K31/4965 ,  A61P1/16

CPC分类号： A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/497 ,  A61K31/724 ,  C07D409/04

摘要： Provided is a method of preparing low-crystallinity oltipraz or amorphous oltipraz. The method includes: obtaining a mixed solution containing oltipraz and a water-soluble polymer or a water-insoluble polymer in a solvent, the solvent being an organic solvent or purified water; and solid-dispersing the oltipraz in the polymer. In the solid-dispersing, the mixed solution may be spray dried using a spray dryer or granulated using a fluid bed granulator.

公开(公告)号：EP1316552B1

公开(公告)日：2006-02-22

申请号：EP02026916.3

申请日：2002-12-03

申请人： CJ Corporation

发明人： Lee, Kwang-hyeg 702-402 Hwangseongvillage, ,  Kim, Jin-wan 101-205 Woojung Apt., 46-5 ,  Choi, Kwang-do ,  Lee, Sang-ho 301-105 Gwanak Seongwon Apt., ,  Cho, Hong-suk

IPC分类号： C07D309/30

CPC分类号： C07D309/30

公开(公告)号：EP1391453B1

公开(公告)日：2005-12-28

申请号：EP03018653.0

申请日：2003-08-20

申请人： CJ Corporation

发明人： Youn, Yong Sik ,  Cho, Seong Hwan ,  Park, Choong Sil ,  Kim, Yun Cheul ,  Lim, Dong Kwon ,  Jung, Sung Hak ,  Lee, Sung Hak ,  Kang, Hyun Suk ,  Park, Kyung Mi ,  Jung, Yun Taek ,  Kim, Young Hoon ,  Yeon, Kyu Jeong #126-801 ,  Chae, Myeong Yun ,  Jin, Hae Tak ,  Suh, Hea Ran ,  Lee, Kwang Hyeg ,  Lee, Hyuk Koo

IPC分类号： C07D211/90 ,  A61K31/4422

CPC分类号： C07D211/90

公开(公告)号：EP1591520A2

公开(公告)日：2005-11-02

申请号：EP05356023.1

申请日：2005-02-04

申请人： CJ Corporation

发明人： Park, Young Hoon, 111-102 Mujigae Daerim Apt. ,  Lee, Byoung Choon ,  Park, Jae Yong ,  Cho, Kwang Myung ,  Shin, Yong Uk

IPC分类号： C12N1/20 ,  C12P13/08 ,  C07K14/245 ,  C12R1/19

CPC分类号： C12P13/08

摘要： Provided are a microorganism capable of producing L-threonine and having an inactivated tyrR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The microorganism can be used to produce L-threonine in high yield.

公开(公告)号：EP1515952A2

公开(公告)日：2005-03-23

申请号：EP03760957.5

申请日：2003-06-16

申请人： CJ Corporation

发明人： CHO, Il-Hwan ,  NOH, Ji-Young ,  PARK, Sang-Wook ,  RYU, Hyung-Chul ,  LIM, Jee-Woong ,  KIM, Jong-Hoon503-503 Gongjak Lucky Apt. ,  CHAE, Myeong-Yun ,  KIM, Dal-Hyun231-2003 Hwanggolmaeul ,  JUNG, Sung-Hak ,  PARK, Hyun-Jung ,  KIM, Young-Hoon103-902 Daewoo ,  MIN, In-Ki601-402 Gahyunmaeul Shinan Apt. 344

IPC分类号： C07D231/20

CPC分类号： C07D231/20 ,  C07D231/18 ,  C07D231/22

摘要： A pyrazole-3-one derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

公开(公告)号：EP1458359A1

公开(公告)日：2004-09-22

申请号：EP02793523.8

申请日：2002-12-26

申请人： CJ Corporation

发明人： CHOI, Jae-Mook ,  JEON, Eun-Kyung ,  KO, Jae-Kyoung ,  PARK, Young-Hwan ,  BAEK, Myoung-Ki ,  YANG, Su-Geun ,  JEONG, Eun-Ju101-1102 Mokhwa Apt. 414

IPC分类号： A61K9/107

CPC分类号： A61K9/1075 ,  A61K9/4858

摘要： A microemulsion preconcentrate is provided, which comprises an active component, an oil, a surfactant, and a hydrophilic solvent selected from the group consisting of propylene glycol diacetate, propylene glycol monoacetate, and salts of the forgoing materials.