公开(公告)号：EP1349572B1

公开(公告)日：2007-09-19

申请号：EP02729589.8

申请日：2002-01-09

申请人： LG Life Sciences Ltd.

发明人： KIM, Kyu-wan ,  JI, Hyi-jeong ,  LEE, Youn-kyeong ,  KIM, Wan-kyu ,  LEE, Hee-ku ,  KIM, Won-kyum

IPC分类号： A61K39/29

CPC分类号： A61K39/0017 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/08 ,  A61K39/099 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/55505 ,  A61K2039/70 ,  C12N2730/10134

摘要： The present invention relates to a method for manufacturing a combined vaccine capable of concurrently preventing multiple diseases such as diphtheria, tetanus, pertussis, and hepatitis B which should be prevented in an infant. The method for manufacturing a combined vaccine according to the present invention includes the steps of independently adsorbing each protective antigen to an adsorbent of a aluminum hydroxide gel with respect to various diseases such as diphtheria, tetanus, pertussis, and hepatitis B which should be prevented in the infants, and combining each protective antigen adsorbed to the adsorbent after the adsorption. In the present invention, it is possible to concurrently prevent multiple diseases such as diphtheria, tetanus, pertussis, and hepatitis B which should be prevented in the infant using a combined vaccine manufactured according to the present invention.

公开(公告)号：EP1458391B1

公开(公告)日：2007-09-05

申请号：EP02795444.5

申请日：2002-11-29

申请人： LG Life Sciences Ltd.

发明人： NICONOVICH, Nancy ,  RITTENHOUSE, Stephen ,  McCLOSKEY, Lynn ,  PAEK, Kyong-Sook, LG Life Sciences Ltd. ,  KIM, Mu-Yong, LG Life Sciences Ltd. ,  YOUN, Ha-Sik, LG Life Sciences Ltd.

IPC分类号： A61K31/47 ,  A61P31/04

CPC分类号： A61K31/545 ,  A61K31/407 ,  A61K31/4375 ,  A61K31/546 ,  Y02A50/473 ,  A61K2300/00

摘要： The present invention relates to a method of treating anti-bacterial infections which method comprises the separate, simultaneous or sequential administration to a patient in need thereof, of an effective amount of gemifloxacin or a salt thereof and a beta-lactam antibiotic.

公开(公告)号：EP1458390A4

公开(公告)日：2007-07-04

申请号：EP02795443

申请日：2002-11-29

申请人： LG LIFE SCIENCES LTD

发明人： NICONOVICH NANCY ,  RITTENHOUSE STEPHEN ,  MCCLOSKEY LYNN ,  PAEK KYONG-SOOK ,  KIM MU-YONG

IPC分类号： A61K31/4353 ,  A61K31/47

CPC分类号： A61K31/4375 ,  A61K31/407 ,  A61K2300/00

摘要： The present invention relates to a method of treating anti-bacterial infections which method comprises the separate, simultaneous or sequential administration to a patient in need thereof, of an effective amount of gemifloxacin or a salt thereof and a carbapenem antibacterial.

公开(公告)号：EP1686853A1

公开(公告)日：2006-08-09

申请号：EP04819020.1

申请日：2004-11-17

申请人： LG Life Sciences Ltd.

发明人： KANG, Kyung-Goo R & D Park, LG Life Sciences Ltd. ,  KIM, Tae-Young R & D Park, LG Life Sciences Ltd. ,  KIM, Dal-Soo R & D Park, LG Life Sciences Ltd. ,  CHUN, Sam-Jae R & D Park, LG Life Sciences Ltd. ,  JOE, Goon-Ho R & D Park, LG Life Sciences Ltd.

IPC分类号： A01N25/04

CPC分类号： A01N25/04 ,  A01N25/30 ,  A01N43/78 ,  A01N47/12 ,  A01N43/76 ,  A01N43/653 ,  A01N43/54 ,  A01N43/50 ,  A01N37/46 ,  A01N37/38 ,  A01N37/34 ,  A01N2300/00

摘要： The present invention relates to a stable aqueous suspension concentrate composition which comprises one or more fungicidal active ingredients and water soluble or water dispersable polyoxyalkylene alkyl ether, which does not form gel in the preparation process, and does not form cake during storage. The stable suspension concentrate is characterized in using appropriate water soluble solvent to act as anti-gel forming and anti-caking agent and an appropriate dispersant.

公开(公告)号：EP1685102A1

公开(公告)日：2006-08-02

申请号：EP04800082.2

申请日：2004-11-12

申请人： LG Life Sciences Ltd. ,  YAMANOUCHI PHARMACEUTICAL CO. LTD.

发明人： LEE, Koo, R & D Park, LG Life Sciences Ltd. ,  PARK, Heui-Sul, R & D Park, LG Life Sciences Ltd. ,  AHN, In-Ae, R & D Park, LG Life Sciences Ltd. ,  YOO, Hyun-Ju, R & D Park, LG Life Sciences Ltd. ,  KIM, Jong-Yup, R & D Park, LG Life Sciences Ltd. ,  CHOI, Deog-Young, R & D Park, LG Life Sciences Ltd ,  YIM, Hyeon-Joo, R & D Park, LG Life Sciences Ltd. ,  CHUNG, Kyung-Ha, R & D Park, LG Life Sciences Ltd. ,  SHIM, Dong-Sup, R & D Park, LG Life Sciences Ltd. ,  LEE, Sang-Kyun, R & D Park, LG Life Sciences Ltd. ,  KONDOH, Yutaka ,  HIRABAYASHI, Ryoji ,  HONDA, Shugo ,  KAKU, Hidetaka ,  SHISHIKURA, Jun-Ichi ,  ITO, Hiroyuki ,  KURAMA, Takeshi

IPC分类号： C07D207/16 ,  C07D207/14

CPC分类号： C04B35/632 ,  C07D205/04 ,  C07D207/14 ,  C07D211/58 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

摘要： The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

摘要翻译： 本发明涉及有效用作黑皮质素受体激动剂的式1化合物及其药学上可接受的盐，水合物，溶剂化物或异构体，以及包含其作为活性成分的黑皮质素受体激动剂组合物。

公开(公告)号：EP1401440A4

公开(公告)日：2006-07-05

申请号：EP00993844

申请日：2000-08-31

申请人： LG LIFE SCIENCES LTD

发明人： AMBLER JANE ,  AMYES SEBASTIAN G ,  ANDREWS JENNIFER MARY ,  APPELBAUM PETER C ,  BARKER PHILIPPA G ,  BEACH MONDEL L ,  BERRY VALERIE JOAN ,  BRIAND JACQUES ,  BROSKEY JOHN P ,  BUTLER DEBORAH ,  CHASSEUR-LIBOTTE MARY-LOUISE ,  CITRON DIANE M ,  CLARK CATHERINE L ,  CLARK SUSAN C ,  COLEMAN KENNETH ,  CRABB DONNA M ,  CREDITO KIM L ,  DAVIDSON ROSS J ,  DEAZAVEDO JOYCE ,  DEMARINI DOUGLAS J

IPC分类号： A61K31/44 ,  C07D471/04 ,  A61K31/444 ,  A61P31/04

CPC分类号： A61K31/44

摘要： This invention relates, in part, to newly identifid methods of using quinolone antibiotics, particulrly a gemifloxacin compound against certain bactera, especially pathogenic bacteria.

公开(公告)号：EP1328552A4

公开(公告)日：2005-11-09

申请号：EP01974948

申请日：2001-10-10

申请人： LG LIFE SCIENCES LTD

发明人： MOON TAE-SEOK ,  LEE JAE-YOUNG ,  KIM JIN-HOON ,  HAN KYU-BOEM

IPC分类号： A61L31/00 ,  A61K31/728 ,  A61L27/20 ,  A61L27/50 ,  A61L31/04 ,  A61P17/16 ,  A61P41/00 ,  C07K2/00 ,  C08B37/00 ,  C08B37/08

CPC分类号： C08B37/0072 ,  A61L27/20 ,  A61L31/042 ,  C08L5/08

摘要： The present invention relates to water-insoluble, crosslinked amide derivatives of hyaluronic acid and manufacturing method thereof, where the amide derivatives of hyaluronic acid are characterized by crosslinking, of polymer or oligomer having two or more amine groups, with hyaluronic acid or its hyaluronate salts through amidation reaction.The water-insoluble, crosslinked amide derivatives of hyaluronic acid according to the present invention may be diversely used for prevention of adhesion after surgical operation, correction of facial wrinkles, dermal augmentation, tissue engineering, osteoarthritic viscosupplement etc.

公开(公告)号：EP1383758A4

公开(公告)日：2005-10-19

申请号：EP02705581

申请日：2002-03-15

申请人： LG LIFE SCIENCES LTD

发明人： YOON SUK-KYOON ,  KIM BONG-CHAN ,  JUNG WON-HYUK ,  LEE JAE-CHUL ,  LEE KOO ,  PARK CHEOL-WON

IPC分类号： C07D333/36 ,  C07B61/00 ,  C07D333/38

CPC分类号： C07D333/38

摘要： The present invention provides a novel process for preparing a compound represented by the above formula 7, which is an important intermediate for an oral thrombin inhibitor, by one-pot reaction. In accordance with the present invention, the above intermediate for the thrombin inhibitor may be obtained in a high yield.

公开(公告)号：EP1583730A1

公开(公告)日：2005-10-12

申请号：EP03772907.6

申请日：2003-11-17

申请人： LG Life Sciences Ltd.

发明人： SHIN, Hyun-Ik,c/o R&D Park, LG Life Sciences Ltd. ,  CHOI, Bo-Seung,c/o R&D Park, LG Life Sciences Ltd

IPC分类号： C07C49/173 ,  C07C51/353 ,  C07C59/90 ,  C07C59/115

CPC分类号： C07C51/09 ,  C07C51/353 ,  C07C67/343 ,  C07C59/215 ,  C07C59/90 ,  C07C69/716

摘要： The present invention is related to a novel process for preparing an optically active 5-hydroxy-3-oxo-hexanoic acid derivative or its tautomer which is useful intermediate for preparing statins such as atorvastatin and rosuvastatin. Blaise reaction of (S)-4-halo-3 -hydroxybutyronitrile with -haloacetate is utilized as a key reaction to provide the product with minimal formation of side products and in good yield.

公开(公告)号：EP1546164A1

公开(公告)日：2005-06-29

申请号：EP03798577.7

申请日：2003-09-22

申请人： LG Life Sciences Ltd.

发明人： CHOI, Jong-Ryoo,R & D Park, LG Life Sciences Ltd. ,  HWANG, Jae-Taeg,R & D Park, LG Life Sciences Ltd. ,  CHO, Dong-Gyu,R & D Park, LG Life Sciences Ltd. ,  ROH, Kee-Yoon,R & D Park, LG Life Sciences Ltd. ,  KIM, Chun-Hyung,R & D Park, LG Life Sciences Ltd. ,  KIM, Chung-Mi,R & D Park, LG Life Sciences Ltd. ,  HAN, Min-Joon,R & D Park, LG Life Sciences Ltd. ,  KIM, Jeong-Min,R & D Park, LG Life Sciences Ltd. ,  CHO, Woo-Young,R & D Park, LG Life Sciences Ltd. ,  KIM, Gyoung-Won,R & D Park, LG Life Sciences Ltd. ,  AHN, Sinbyoung,R & D Park, LG Life Sciences Ltd.

IPC分类号： C07F9/6561 ,  C07F9/6509 ,  A61K31/675

CPC分类号： C07F9/65616 ,  C07F9/4006 ,  C07F9/65121

摘要： The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.