公开(公告)号：EP1322673A1

公开(公告)日：2003-07-02

申请号：EP01972171.1

申请日：2001-09-20

申请人： SANOFI-SYNTHELABO ,  Akzo Nobel N.V.

发明人： DUCHAUSSOY, Philippe ,  HERBERT, Jean-Marc ,  PETITOU, Maurice ,  SAVI, Pierre

IPC分类号： C08B37/00 ,  A61K31/715

CPC分类号： C08B37/006 ,  A61K31/715 ,  C08B37/00 ,  C08B37/0063

摘要： The invention concerns novel synthetic polysaccharides, with antithrombotic activity, having at least a covalent bond with biotin or a biotin derivative and a method using avidin or streptavidin for neutralising said polysaccharides.

公开(公告)号：EP1066248B1

公开(公告)日：2003-06-18

申请号：EP99909013.7

申请日：1999-03-17

申请人： SANOFI-SYNTHELABO

发明人： DORMOY, Jean-Robert ,  GOUBET, Dominique ,  MOREAU, Patrice

IPC分类号： C07C251/24 ,  C07C251/48 ,  C07C255/50

CPC分类号： C07C251/48 ,  C07C251/24

公开(公告)号：EP0950053B1

公开(公告)日：2003-06-11

申请号：EP97953948.3

申请日：1997-12-24

申请人： SANOFI-SYNTHELABO

发明人： BARONI, Marco ,  CARDAMONE, Rosanna ,  FOURNIER, Jacqueline ,  GUZZI, Umberto ,  IELMINI, Alessandra

IPC分类号： C07D211/70 ,  A61K31/44

CPC分类号： C07D211/70 ,  A61K31/4418

公开(公告)号：EP1307182A2

公开(公告)日：2003-05-07

申请号：EP01958205.5

申请日：2001-07-31

申请人： SANOFI-SYNTHELABO

发明人： CHARLIER, Anne ,  HENRION, Louis

IPC分类号： A61K9/70 ,  A61K47/10 ,  A61K47/14

CPC分类号： A61K9/7061 ,  A61K9/0014 ,  A61K9/7015 ,  A61K31/421 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14

摘要： The invention concerns a pharmaceutical composition for transdermal delivery of befloxatone, capable of being in the form of gel, ointment or transdermal patch or a sprayed film. The invention is characterised in that it comprises at least an absorption promoter.

公开(公告)号：EP0876482B1

公开(公告)日：2003-03-19

申请号：EP96938273.8

申请日：1996-11-07

申请人： SANOFI-SYNTHELABO

发明人： CAPUT, Daniel ,  FERRARA, Pascual ,  LAURENT, Patrick ,  VITA, Natalio

IPC分类号： C12N15/12 ,  C07K14/715 ,  C12N15/85 ,  C12N5/10 ,  C12Q1/68 ,  C12N15/11 ,  G01N33/53 ,  C07K16/28 ,  G01N33/577 ,  G01N33/68 ,  A61K38/17

CPC分类号： C07K14/7155 ,  A61K38/00

摘要： A purified polypeptide including an amino acid sequence selected from (a) SEQ ID no. 2, and (b) any biologically active sequence derived from SEQ ID no. 2, is disclosed.

公开(公告)号：EP1289986A1

公开(公告)日：2003-03-12

申请号：EP01938361.1

申请日：2001-05-29

申请人： SANOFI-SYNTHELABO

发明人： GALLI, Frédéric ,  LECLERC, Odile ,  LOCHEAD, Alistair

IPC分类号： C07D471/08 ,  A61K31/55 ,  A61P25/00

CPC分类号： C07D471/08

摘要： The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4 and R5 represent each, independently of one another, a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy or phenyl group, two of those substituents in adjacent positions capable of representing together a methylenedioxy group, and R6 represents a hydrogen atom or a (C1-C6)alkyl group. The invention also concerns the therapeutic use of said compounds.

公开(公告)号：EP1161434B1

公开(公告)日：2003-01-29

申请号：EP00907746.2

申请日：2000-03-01

申请人： SANOFI-SYNTHELABO

发明人： GALLI, Frédéric ,  JEGHAM, Samir ,  LOCHEAD, Alistair ,  SAMSON, Axelle

IPC分类号： C07D491/22 ,  A61K31/44 ,  A61P25/00

CPC分类号： C07D491/22

摘要： The invention concerns compounds of general formula (I) wherein: R1 represents a hydrogen atom, an alkyl, phenylalkyl, phenylhydroxyalkyl, furanylalkyl or furanylhydroxyalkyl group; R2 represents either a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, nitro, acetyl, alkoxy, amino group of general formula NR4R5 wherein: R4 and R5 represent each a hydrogen atom or an alkyl group or form, with the nitrogen atom which bears them, a C4-C7 cycle, or a phenyl or naphthyl group optionally substituted by a halogen atom or a trifluoromethyl, trifluoromethoxy, cyano, hydroxy, nitro, acetyl alkyl, alkoxy, or methylenedioxy group; and R3 represents a hydrogen or halogen atom or an alkyl group.

公开(公告)号：EP1105102B1

公开(公告)日：2003-01-02

申请号：EP99936748.5

申请日：1999-08-18

申请人： SANOFI-SYNTHELABO

发明人： ALEMAN, Claude Le Logis des Pins ,  BREUL, Thierry

IPC分类号： A61K9/19 ,  A61K31/4365

CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K31/4365 ,  A61K47/10 ,  A61K47/14

摘要： The invention concerns an aqueous pharmaceutical composition containing a lyophilisate consisting of clopidogrel or ticlopidin optionally in the form of a pharmaceutically acceptable salt, of Pluronic F683reconstituted in a recovery solvent comprising a basic pH modifying agent compatible with parenteral administration and Solutol HS153.

公开(公告)号：EP0765330B1

公开(公告)日：2002-11-27

申请号：EP95922309.0

申请日：1995-06-13

申请人： SANOFI-SYNTHELABO

发明人： RUBIN, Byron ,  MATTES, Kenneth, C. ,  MUNGAL, Terrence, C.

IPC分类号： C07D499/00 ,  A61K31/425

CPC分类号： C07D499/00

摘要： The present invention is related to compounds which inhibit pancreatic cholesterol esterase. The compounds have formula (I), wherein R1 is H or C¿1-6? alkyl; R?2¿ is H or C¿1-6? alkyl; R?3¿ is H or C¿1-6? alkyl; X is CHR?6¿, S or O; R6 is H or C¿1-6? alkyl; R?4¿ is a hydrophobic moiety; and pharmaceutically acceptable salts thereof.

公开(公告)号：EP1257308A1

公开(公告)日：2002-11-20

申请号：EP01903875.1

申请日：2001-01-05

申请人： SANOFI-SYNTHELABO

发明人： LOURENCO, Armindo ,  STEIMER, Benoît

IPC分类号： A61M5/31 ,  A61M5/32 ,  A61M5/50

CPC分类号： A61M5/3135 ,  A61M5/3202 ,  A61M5/326 ,  A61M5/5086 ,  A61M2005/3109 ,  A61M2005/3118 ,  A61M2005/3121

摘要： The invention concerns an injection device comprising a syringe body tubular element (9) provided with finger-pressing members (23) for holding said injection device to inject a dose of liquid, in particular medicinal liquid. The invention is characterised in that the finger-pressing members consist of a flange (23), provided with an upper surface and a lower surface, including two portions with symmetrical outline (50, 51), called gripping portions, having lower support surfaces for the user's fingers, and between said support surfaces, two portions with diametrically opposed symmetrical outlines (52), called indexing portions, including in the extension of the lower surface of said flange, a lower surface having a convex profile formed by two slopes symmetrical relative to a longitudinal axis.