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公开(公告)号：EP0301907B1
公开(公告)日：1991-04-17
申请号：EP88307058.3
申请日：1988-07-29
发明人： Takeda, Ken'ichi , Horibe, Isao
IPC分类号： C07C49/617 , C07C49/693 , C07C49/727 , C07C49/753 , A61K31/12 , C07D317/72
CPC分类号： C07D317/72
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公开(公告)号：EP0287110A3
公开(公告)日：1991-01-09
申请号：EP88106040.4
申请日：1988-04-15
发明人： Kondo, Eiji , Kawamura, Yoshimi , Tsuji, Naoki , Matsumoto, Koichi , Kobayashi, Masaaki , Kamigauchi, Toshiyuki , Hayashi, Yoshiyuki , Konishi, Takao
CPC分类号： C07K9/008
摘要： Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria and stimulate growth of animals.
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公开(公告)号：EP0398692A2
公开(公告)日：1990-11-22
申请号：EP90305303.1
申请日：1990-05-16
发明人： Hayase, Yoshio , Kataoka, Takahiro , Takenaka, Hideyuki , Ichinari, Mitsuhiro , Masuko, Michio , Takahashi, Toshio , Tanimoto, Norihiko
IPC分类号： C07C251/48 , A01N37/50 , C07C323/57 , C07C317/44 , C07D239/34 , C07C323/63 , C07F7/10 , C07D213/643 , C07D309/12 , C07D277/68 , C07D215/227
CPC分类号： C07C249/12 , A01N37/50 , C07C251/48 , C07C317/44 , C07C323/60 , C07D213/64 , C07D215/227 , C07D239/34 , C07D277/68 , C07D303/46 , C07D307/36 , C07D307/40 , C07D307/42 , C07D309/12 , C07F7/10
摘要： A fungicidal composition for agricultural use, which comprises a compound of the formula:
wherein R 1 and R 2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R 3 is lower alkyl or cyclo(lower)alkyl; R4 and R 5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, said phenyl group or heterocyclic group being optionally substituted with not more than three substituents; and Z is -CH 2 -, -CH(OH)-, -CO-, -O-, -S-, -SO-, -NR- (R being hydrogen or lower alkyl), -CH 2 CH 2 -, -CH = CH-,
-CH 2 0-, -CH 2 S-, CH 2 S0-, -OCH 2 -, -SCH 2 - or -SOCH 2 -.摘要翻译： 一种农业用杀真菌组合物，其包含下式化合物：其中R 1和R 2各自为氢，低级烷基或环（低级）烷基; R 3是低级烷基或环（低级）烷基; R 4和R 5各自为氢，低级烷基，低级烷氧基，卤素取代的低级烷基，低级烷基取代的甲硅烷基，卤素或硝基; A表示不饱和烃基，卤素取代的不饱和烃基，苯基或杂环基，所述苯基或杂环基任选被不多于三个取代基取代; 且Z为-CH 2 - ， - CH（OH） - ， - CO - ， - O - ， - S - ， - SO - ， - NR-（R为氢或低级烷基） - ，CH 2 -CH 2 - ， - CH 2 S - ，CH 2 SO - ， - OCH 2 - ， - CH 2 - 或-SOCH 2 - 。 米
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公开(公告)号：EP0398621A2
公开(公告)日：1990-11-22
申请号：EP90305189.4
申请日：1990-05-15
发明人： Yoshida, Nobuo , Inouye, Ken , Kono, Masao
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N33/5306
摘要： This invention provides an immunoassay of elastase-1, which comprises subjecting (a) labelled elastase-1 treated with Boc-TACK and (b) elastase-1 to be measured to competitive reaction with anit-elastase-1 antibody, wherein the Boc-TACK denotes (CH₃)₃COCO[NHCH(CH₃)CO]₃CH₂Cl.
摘要翻译： 本发明提供弹性蛋白酶-1的免疫测定法，其包括：（a）用Boc-TACK处理的标记的弹性蛋白酶-1和（b）弹性蛋白酶-1进行测定以与弹性蛋白酶-1抗体竞争反应，其中Boc- TACK表示（CH3）3COCO [NHCH（CH3）CO] 3CH2Cl。
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25.发明公开A phospholipase A2 inhibitor, method for producing it and pharmaceutical or veterinary formulations comprising said inhibitor 失效磷脂酶A2抑制剂，其制备方法和含有它的药物或兽药组合物的方法。
公开(公告)号：EP0395418A1
公开(公告)日：1990-10-31
申请号：EP90304552.4
申请日：1990-04-26
发明人： Yoshida, Tadasi , Arita, Hitoshi , Shoji, Jun'ichi , Inoue, Keizo , Matsutani, Shigeru , Kawamura, Yoshimi
IPC分类号： C07D311/82 , C12P17/06 , C12N1/14 , A61K31/35
CPC分类号： C12R1/645 , C07D311/82 , C12P17/06
摘要： A compound of the formula:
wherein the wave line means α-bond or β-bond, which compound is useful as a phospholipase A₂ inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.摘要翻译： 式的化合物：
worin波浪线指α，β硼化物或硼化物，该化合物是作为磷脂酶A2抑制剂是有用的。 因此提供了用于生产所述化合物的，药物组合物，含有该化合物，和梭孢壳属微生物栖土RF-143制备化合物的细胞培养过程。 -
26.发明公开Pharmaceutical or veterinary preparations of substituted hexenoic acid derivatives 失效Pharmazutische oderveterinärePräparatevon substituteiertenHexensäurederivaten。
公开(公告)号：EP0384747A1
公开(公告)日：1990-08-29
申请号：EP90301895.0
申请日：1990-02-19
IPC分类号： C07C311/20 , A61K31/18 , C07D257/06
CPC分类号： C07D257/04 , C07C311/20 , C07C405/0091 , C07C2602/42 , Y10S514/822 , Y10S514/826 , Y10S514/929
摘要： Pharmaceutical or veterinary preparations for use in the treatment of thromboxane A₂ mediating diseases, comprising a pharmacologically effective amount of at least one compound of the formula:
wherein R¹ is carboxyl or 5-tetrazolyl, R² is hydrogen, methyl, hydroxy, chloro, or bromo, or a pharmaceutically acceptable ester or salt thereof, formulated for such use with one or more non-toxic pharmaceutically or veterinarily acceptable carrier and optionally in unit dosage form.摘要翻译： 包含药理学有效量的至少一种下式的化合物：其中R 1为羧基或5-四唑基的化合物，其中R 2为氢 ，甲基，羟基，氯或溴，或其药学上可接受的酯或盐，与一种或多种无毒的药学上或兽医学上可接受的载体配制用于任选的单位剂型。
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27.发明公开Monoesters of arylacetic acid, their production and use 失效Arylessigsäuremonoester，deren Herstellung und Verwendung。
公开(公告)号：EP0373931A2
公开(公告)日：1990-06-20
申请号：EP89313075.7
申请日：1989-12-14
IPC分类号： C07C69/753 , C07C67/08
CPC分类号： C07C69/753 , Y02P20/55
摘要： The invention provides optically active esters of arylacetic acid of the formula:
wherein R¹ is hydrogen or optionally substituted C₁-C₂ alkyl or phenyl or when both taken together form C₂-C₆ alkylene, C₂ or C₄-C₆ alkenylene, or a bicyclic-ring; R² is hydrogen or methyl; X is a single bond or CH₂, C=O, N-R⁴, O, S, CHNHR⁴, CHCH₃, CH-Ar, or CHOR⁵ (provided that when X is single bond or CH₂, C=O, N-R⁴, O, or S, R¹ and R² are not simultaneously hydrogen or methyl); R³ is hydrogen, optionally substituted alkyl, or optionally substituted aralkyl; R⁴ is hydrogen or an amino protecting group; R⁵ is hydrogen or a hydroxy protecting group; and Ar is optionally substituted aryl. These esters may be prepared by the reaction of a σ symmetric acid anhydride with an (R)- or (S)-arylacetic acid derivative in high optical purity, and are useful as intermediates for various optically active natural products and medicines.摘要翻译： 本发明提供下式的芳基乙酸的光学活性酯：其中R 1为氢或任选取代的C 1 -C 2烷基或苯基，或两者一起形成C 2 -C 6亚烷基，C 2或C 4 -C 6亚烯基， 或双环; R 2是氢或甲基; X是单键或CH 2，C = O，NR 4，O，S，CHNHR 4，CHCH 3，CH-Ar或CHOR 5（条件是当X是单键或CH 2时，C = O，NR 4，O或S，R 1和R 2不同时为氢或甲基）; R 3是氢，任选取代的烷基或任选取代的芳烷基; R 4是氢或氨基保护基; R 5是氢或羟基保护基; 并且Ar是任选取代的芳基。 这些酯可以通过σ对称酸酐与高光学纯度的（R） - 或（S） - 芳基乙酸衍生物的反应制备，并且可用作各种光学活性天然产物和药物的中间体。
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公开(公告)号：EP0267378A3
公开(公告)日：1990-04-25
申请号：EP87112029.1
申请日：1987-08-19
IPC分类号： A61K31/12 , A61K31/215 , A61K31/22 , A61K31/255 , A61K31/34 , A61K31/26 , A61K31/335
CPC分类号： A61K31/12 , A61K31/215 , A61K31/22 , A61K31/255 , A61K31/26 , A61K31/335 , A61K31/34
摘要： An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula;
(wherein R₁ is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R₂ is hydrogen, halogen, hydroxy, alkyl or alkoxy)
and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.-
公开(公告)号：EP0292051A3
公开(公告)日：1990-03-21
申请号：EP88200933.5
申请日：1988-05-10
IPC分类号： C07D495/04 , A61K31/435
CPC分类号： C07D495/04
摘要： A compound of the formula:
(wherein R¹ is hydrogen, C₁-C₅ alkyl, C₁-C₅ alkoxy, C₁-C₅ alkoxycarbonyl, or trifluoromethyl; R² is hydrogen, C₁-C₅ alkoxycarbonyl, C₆-C₁₂ aryloxycarbonyl, C₁-C₅ alkanoyloxy-C₁-C₅ alkyl, C₁-C₅ alkoxycarbonyloxy-C₁-C₅ alkyl, C₁-C₅ acylamino-C₁-C₅ alkyl, 2-hydroxy-1-C₂-C₅ alkenyl, phthalimido-C₁-C₅ alkyl, halogeno-C₁-C₅ alkoxycarbonyl-C₁-C₅ alkyl, hydroxy-C₁-C₅ alkyl, C₁-C₅ alkylthio-C₁-C₅ alkyl, or C₁-C₅ alkylsulfinyl-C₁-C₅ alkyl;
m is an integer of 0 or 1;
R³ and R⁴ each is hydrogen, halogen, cyano, C₁-C₅ alkyl, amino, C₁-C₅ alkoxy, C₆-C₁₂ aryl-C₁-C₅ alkoxy, C₁-C₅ alkoxycarbonyl, fluoro-C₁-C₅ alkoxy, C₁-C₅ alkanoylamino, or carbamoyl) or its salt, being useful as antiulcer agents, is provided.-
30.发明公开Thymic stroma-derived T cell growth factor and process for its production 失效THYMIC STRMA衍生的T细胞生长因子及其生产工艺
公开(公告)号：EP0310056A3
公开(公告)日：1989-06-14
申请号：EP88116054.3
申请日：1988-09-29
申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. , Fujiwara, Hiromi
CPC分类号： C07K14/52
摘要： Disclosed is a novel T cell growth factor which is derived from a thymic stroma and promotes the growth of T cell clones and/or thymocytes and a process for its production which comprises culturing thymic stroma cells in a culture medium and collecting a factor promoting the growth of T cells form the supernatant of said culture medium.
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