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21.发明授权CYCLOSPORIN ANALOGS AND THEIR USE IN THE TREATMENT OF HCV INFECTIONS 有权CYCLOSPORINANALOGE及它们在HCV感染的治疗
公开(公告)号：EP2280989B1
公开(公告)日：2016-02-10
申请号：EP09773881.9
申请日：2009-06-05
申请人： Scynexis, Inc.
发明人： LI, Keqiang , MAMAI, Ahmed , PEEL, Michael, Robert
CPC分类号： C07K7/645
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公开(公告)号：EP2007396B1
公开(公告)日：2013-02-13
申请号：EP07754382.5
申请日：2007-03-29
发明人： BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , TSE, Bruno , DROPINSKI, James , MENG, Dongfang , GREENLEE, Mark, L. , PEEL, Michael , FAN, Weiming , MAMAI, Ahmed , LIU, Hao , LI, Keqaing
CPC分类号： C07J71/0005
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公开(公告)号：EP2197447A4
公开(公告)日：2012-11-21
申请号：EP08836095
申请日：2008-09-25
申请人： MERCK SHARP & DOHME , SCYNEXIS INC
发明人： BALKOVEC JAMES M , SILIPHAIVANH PHIENG , BOUFFARD FRANCES AILEEN , PEEL MICHAEL R , FAN WEIMING , MAMAI AHMED , DIMICK GRAY SARAH M
IPC分类号： A61K31/497 , A61P31/10 , C07J71/00
CPC分类号： C07J71/0005
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公开(公告)号：EP2326181A1
公开(公告)日：2011-06-01
申请号：EP09806945.3
申请日：2009-08-07
发明人： GREENLEE, Mark, L. , WILKENING, Robert , APGAR, James , SPERBECK, Donald , WILDONGER, Kenneth, James , MENG, Dongfang , PARKER, Dann, L. Jr. , PACOFSKY, Gregory, James , HEASLEY, Brian, Haid , MAMAI, Ahmed , NELSON, Kingsley
CPC分类号： A61K31/343 , A01N43/653 , A61K31/21 , A61K31/41 , C07D493/08 , C07D519/00
摘要： Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (l,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs,,as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
摘要翻译： 本文公开了enfumafungin的新衍生物及其药学上可接受的盐，水合物和前药。 还公开了包含此类化合物的组合物，制备此类化合物的方法以及使用此类化合物作为抗真菌剂和/或（1,3）-β-D-葡聚糖合酶抑制剂的方法。 公开的化合物，它们的药学上可接受的盐，水合物和前药以及包含此类化合物，盐，水合物和前药的组合物可用于治疗和/或预防真菌感染和相关疾病和病症。
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公开(公告)号：EP2326180A1
公开(公告)日：2011-06-01
申请号：EP09806946.1
申请日：2009-08-10
发明人： GREENLEE, Mark, L. , WILKENING, Robert , APGAR, James , SPERBECK, Donald , WILDONGER, Kenneth, James , MENG, Dongfang , PARKER, Dann, L., Jr. , MAMAI, Ahmed
CPC分类号： A61K31/21 , A61K31/41 , C07D405/04
摘要： Novel derivatives of enfumafungin are disclosed herein, along with' their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and/or inhibitors of (l,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
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26.发明授权ARYLALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION 有权环孢菌素A在治疗和预防病毒感染的芳基烷基和杂衍生物
公开(公告)号：EP1931696B1
公开(公告)日：2011-02-16
申请号：EP06816230.4
申请日：2006-10-02
申请人： Scynexis, Inc.
发明人： HOUCK, David, Renwick , LI, Keqiang
CPC分类号： C07K7/645
摘要： This invention provides compounds of general formula (I): (I) wherein A, B, R 1 , R2, and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus and/or human immunodeficiency virus.
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27.发明公开CYCLOSPORIN ANALOGS AND THEIR USE IN THE TREATMENT OF HCV INFECTIONS 有权CYCLOSPORINANALOGE及它们在HCV感染的治疗
公开(公告)号：EP2280989A2
公开(公告)日：2011-02-09
申请号：EP09773881.9
申请日：2009-06-05
申请人： Scynexis, Inc.
发明人： LI, Keqiang , MAMAI, Ahmed , PEEL, Michael, Robert
CPC分类号： C07K7/645
摘要： Disclosed are cyclosporine derivatives in which the 3-Sarcosine carbon and 5-Valine nitrogen are each substituted by a non-hydrogen substituent, and their use as pharmaceuticals, in particular for the treatment of hepatitis C virus.
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公开(公告)号：EP2023918A2
公开(公告)日：2009-02-18
申请号：EP07795039.2
申请日：2007-05-18
申请人： Scynexis, Inc.
IPC分类号： A61K31/395 , A61P27/02
CPC分类号： A61K31/395 , A61K31/4025 , A61K31/4178 , A61K31/4453 , A61K31/496 , A61K31/5355 , A61K45/06
摘要： Provided herein are methods for treatment of ocular diseases. The methods comprise administering a compound of general Formula (I): wherein R1, R2, R3, R4 and Ak are as defined in the specification.
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公开(公告)号：EP2007396A1
公开(公告)日：2008-12-31
申请号：EP07754382.5
申请日：2007-03-29
发明人： BALKOVEC, James, M. , BOUFFARD, Frances, Aileen , TSE, Bruno , DROPINSKI, James , MENG, Dongfang , GREENLEE, Mark, L. , PEEL, Michael , FAN, Weiming , MAMAI, Ahmed , LIU, Hao , LI, Keqaing
CPC分类号： C07J71/0005
摘要： The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
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30.发明公开3-ETHER AND 3-THIOETHER SUBSTITUTED CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF HEPATITIS C INFECTION 有权3-醚和3-硫醚取代CICLOSPORINDERIVATE用于治疗和预防丙型肝炎感染
公开(公告)号：EP1802650A2
公开(公告)日：2007-07-04
申请号：EP05815625.8
申请日：2005-09-30
申请人： Scynexis, Inc.
IPC分类号： C07K7/64
摘要： This invention relates to cyclosporin derivatives of general formula (I) wherein A, B, R1,R2 and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus.
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