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61 条记录 (耗时 0.023 秒)

    Substituted 1,3-oxathiolanes with antiviral properties
    21.
    发明公开
    Substituted 1,3-oxathiolanes with antiviral properties 失效
    Substituierte 1,3-Oxathiolane mit antiiralen Eigenschaften

    公开(公告)号：EP1153924A2

    公开(公告)日：2001-11-14

    申请号：EP01118810.9

    申请日：1995-04-19

    申请人： BIOCHEM PHARMA INC

    发明人： Mansour, Tarek S. ,  Jin, Haolun

    IPC分类号： C07D411/04 ,  A61K31/505

    CPC分类号： C07H21/00 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D409/04 ,  C07D411/04 ,  C07D473/00 ,  C07F7/1856 ,  A61K2300/00

    摘要： This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of formula (I) wherein R 1 is hydrogen, and R 2 is cytosine or 5-fluorocytosine, and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.

    摘要翻译： 本发明涉及式（I）的新型顺式取代的1,3-氧硫杂环戊烷的单一对映异构体，其中R 1是氢，R 2是胞嘧啶或5-氟胞嘧啶，以及其药学上可接受的盐和酯。 本发明还涉及含有它们的药物组合物以及这些化合物作为抗病毒剂的用途，特别是在联合治疗中。

    NOVEL HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN AND USE THEREOF
    24.
    发明公开
    NOVEL HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN AND USE THEREOF 失效
    杂环化合物疼痛治疗及其用途

    公开(公告)号：EP0850234A1

    公开(公告)日：1998-07-01

    申请号：EP96921855.0

    申请日：1996-07-12

    申请人： BIOCHEM PHARMA INC.

    发明人： DIMAIO, John ,  DIXIT, Dilip M

    IPC分类号： A61K31 ,  A61P25 ,  A61P43 ,  C07C215 ,  C07D221 ,  C07D225 ,  C07D313 ,  C07D337

    CPC分类号： C07C215/44 ,  C07D225/08 ,  C07D313/20 ,  C07D337/16

    摘要： Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl, or halogen; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. For the treatment of pain and pharmaceutically acceptable compositions comprising those compounds. The compounds of this invention act as agonists at the opiate receptor.

    Use of dideoxy nucleoside analogues in the treatment of viral infections
    28.
    发明公开
    Use of dideoxy nucleoside analogues in the treatment of viral infections 失效
    Verbindung von Nucleocidanaloga zur Behandlung viruser Infektionen

    公开(公告)号：EP0765665A1

    公开(公告)日：1997-04-02

    申请号：EP96116738.4

    申请日：1993-12-22

    申请人： BIOCHEM PHARMA INC.

    发明人： Mansour, Tarek ,  Tse, Alan H.L.

    IPC分类号： A61K31/70

    CPC分类号： A61K31/70 ,  Y10S514/885 ,  Y10S514/894

    摘要： The present invention concerns the use and method of treatment of β-L-5-fluoro-2',3'-dideoxycytidine (β-L-5F-ddC), and pharmaceutically acceptable derivatives thereof, for use in the treatment of viral infections, specifically HIV and hepatitis B infections. The present invention also includes the use and method of treatment of β-D-5-fluoro-2',3'-dideoxycytidine (β-D-5F-ddC) for use in the treatment of hepatitis B infections.

    摘要翻译： 本发明涉及用于治疗病毒感染的β-L-5-氟-2'，3'-二脱氧胞苷（β-L-5F-ddC）及其药学上可接受的衍生物的用途和方法 ，特别是艾滋病毒和乙型肝炎感染。 本发明还包括用于治疗乙型肝炎感染的β-D-5-氟-2'，3'-双脱氧胞苷（β-D-5F-ddC）的用途和方法。

    Substituted-1,3-oxathiolanes with antiviral properties
    30.
    发明公开
    Substituted-1,3-oxathiolanes with antiviral properties 失效
    具有抗病毒性质的取代的1,3-氧硫杂环戊烷

    公开(公告)号：EP0711771A2

    公开(公告)日：1996-05-15

    申请号：EP95120531.9

    申请日：1990-02-08

    申请人： BIOCHEM PHARMA INC.

    发明人： Belleau, Bernard ,  Nguyen-Ba, Nghe ,  Belleau, Pierette

    IPC分类号： C07D473/00 ,  C07D411/04

    CPC分类号： C07D411/14 ,  C07D327/04 ,  C07D405/04 ,  C07D411/04 ,  C07D473/00 ,  C07D473/40

    摘要： Disclosed are compounds of the formula

    wherein R₁ is hydrogen;
       R₂ is a purine or pyrimidine base or an analogue or derivative thereof;
       Z is S, S=O or SO₂; and
       pharmaceutically acceptable derivatives thereof.
    Also described are use of the compounds as antiviral agents, pharmaceutical formulations, and methods for the preparation of the compounds.

    摘要翻译： 公开了下式的化合物：其中R 1是氢; R 2是嘌呤或嘧啶碱或其类似物或衍生物; Z是S，S = O或SO 2; 及其药学可接受的衍生物。 还描述了这些化合物作为抗病毒剂，药物制剂和制备该化合物的方法的用途。