公开(公告)号：EP1832599A2

公开(公告)日：2007-09-12

申请号：EP06076852.0

申请日：2001-04-12

申请人： HUMAN GENOME SCIENCES, INC. ,  Novozymes Delta Limited

发明人： Ballance, David James ,  Sleep, Darrell ,  Turner, Andrew John ,  Sadeghi, Homayoun ,  Prior, Christopher P.

IPC分类号： C07K1/00 ,  C07K14/765

CPC分类号： A61K38/4846 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/21 ,  A61K38/212 ,  A61K38/38 ,  A61K47/42 ,  A61K47/65 ,  A61K48/00 ,  A61K2039/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/65 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/76 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/50 ,  C07K2319/75 ,  C12N9/96 ,  C12N15/62 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/412

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

摘要翻译： 本发明包括清蛋白融合蛋白。 编码本发明的清蛋白融合蛋白的核酸分子也包括在本发明中，含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的清蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 此外，本发明涵盖包含清蛋白融合蛋白的药物组合物以及使用本发明的清蛋白融合蛋白治疗，预防或改善疾病，病症或病症的方法。

公开(公告)号：EP1007670B1

公开(公告)日：2007-08-15

申请号：EP98920965.5

申请日：1998-05-07

申请人： HUMAN GENOME SCIENCES, INC.

发明人： RUBEN, Steven, M. ,  LI, Yi

IPC分类号： C12N15/12 ,  C12Q1/68 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/705

摘要： Two human G-protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.

公开(公告)号：EP1803730A1

公开(公告)日：2007-07-04

申请号：EP06015131.3

申请日：2001-04-12

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Rosen, Craig A. ,  Haseltine, William A.

IPC分类号： C07K1/00 ,  C07K14/765

CPC分类号： A61K38/4846 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/21 ,  A61K38/212 ,  A61K38/38 ,  A61K47/42 ,  A61K47/65 ,  A61K48/00 ,  A61K2039/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/65 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/76 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/50 ,  C07K2319/75 ,  C12N9/96 ,  C12N15/62 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/412

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：EP0970213B1

公开(公告)日：2007-01-24

申请号：EP98912966.3

申请日：1998-03-17

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  GENTZ, Reiner, L. ,  YU, Guo-Liang ,  SU, Jeffrey, Y. ,  ROSEN, Craig, A.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K16/28 ,  A61K38/17 ,  A61K39/395 ,  C12N15/62

CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

公开(公告)号：EP0891372B1

公开(公告)日：2006-06-07

申请号：EP96912461.9

申请日：1996-03-26

申请人： HUMAN GENOME SCIENCES, INC.

发明人： SOPPET, Daniel, R. ,  LI, Haodong

IPC分类号： C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C07K14/475 ,  A61K47/48 ,  C07K14/495

CPC分类号： C07K14/475 ,  A61K38/00 ,  C12N2799/026

公开(公告)号：EP1185297B1

公开(公告)日：2006-05-10

申请号：EP00939739.9

申请日：2000-06-09

申请人： MEDIMMUNE, INC. ,  HUMAN GENOME SCIENCES, INC.

发明人： ADAMOU, John, E. ,  CHOI, Gil, H.

IPC分类号： A61K39/09 ,  C07K16/12 ,  C12N5/10 ,  A61K39/40 ,  A61P31/04 ,  C07K14/315

CPC分类号： C07K16/1275 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/523 ,  C07K14/3156

摘要： The present invention relates to novel immunogenic polypeptides, and fragments thereof, and vaccines for the prevention and treatment of pneumococcal infection, especially by Streptococcus pneumoniae . The invention also relates to antibodies against the disclosed polypeptides, as well as vacccines containing said polypeptides and methods of disease prevention.

公开(公告)号：EP1499353A4

公开(公告)日：2006-04-05

申请号：EP03728362

申请日：2003-04-10

申请人： HUMAN GENOME SCIENCES INC

发明人： ROSEN CRAIG A ,  RUBEN STEVEN M

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K47/48 ,  A61K51/10 ,  A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  C12N1/21 ,  C12N5/24 ,  C12N15/13 ,  C12N15/70 ,  C12Q1/68 ,  G01N33/577 ,  G01N33/68

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76

摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding anti­TL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.

公开(公告)号：EP1507793A4

公开(公告)日：2006-02-01

申请号：EP02786413

申请日：2002-10-16

申请人： HUMAN GENOME SCIENCES INC

发明人： YU GUO-LIANG ,  EBNER REINHARD ,  NI JIAN ,  ROSEN CRAIG A ,  LAIRD MICHAEL W ,  ULLRICH STEPHEN

IPC分类号： A61K38/19 ,  A61K51/08 ,  C07K14/52 ,  C07K14/525 ,  C07K2/00 ,  A61K38/16 ,  C07K14/00

CPC分类号： A61K51/08 ,  A61K38/00 ,  C07K14/525

公开(公告)号：EP0833948B1

公开(公告)日：2005-12-21

申请号：EP95923729.8

申请日：1995-06-06

申请人： HUMAN GENOME SCIENCES, INC.

发明人： SOPPET, Daniel, R. ,  Li, Yi ,  DILLON, Patrick, J.

IPC分类号： C12Q1/70 ,  G01N33/53 ,  C12N15/00 ,  C12N1/20 ,  C12N1/14 ,  C12N5/00 ,  C07K1/00 ,  C12P21/08 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/57419 ,  A61K38/00 ,  C07K14/47 ,  C12N2799/026

公开(公告)号：EP1228082A4

公开(公告)日：2005-11-16

申请号：EP00947553

申请日：2000-07-20

申请人： HUMAN GENOME SCIENCES INC

发明人： ROSEN CRAIG A ,  RUBEN STEVEN M ,  EBNER REINHARD ,  DUAN ROXANNE D ,  NI JIAN ,  SOPPET DANIEL R ,  MOORE PAUL A ,  SHI YANG-GU ,  LAFLEUR DAVID W ,  OLSEN HENRIK S ,  BIRSE CHARLES E ,  KOMATSOULIS GEORGES A

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61P9/10 ,  A61P17/02 ,  A61P17/06 ,  A61P25/00 ,  A61P25/02 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K5/04 ,  C07K16/00

CPC分类号： C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/622 ,  C07K2319/30