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公开(公告)号：EP2288919B1
公开(公告)日：2016-12-21
申请号：EP09751377.4
申请日：2009-05-19
发明人： SCHOLTENS, Tycho, M. , SCHREUDER, Frederik , GREVE, Jan , TIBBE, Arjan , TERSTAPPEN, Leon, W., M., M.
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54326
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22.发明授权GENE-BASED PREDICTION OF PSA RECURRENCE FOR CLINICALLY LOCALIZED PROSTATE CANCER PATIENTS 有权的PSA复发的临床局限性前列腺癌患者的基于基因的预测
公开(公告)号：EP2553445B1
公开(公告)日：2016-03-30
申请号：EP11763422.0
申请日：2011-03-31
发明人： TALANTOV, Dimitri , JATKOE, Timothy , ZHANG, Yi , WANG, Yixin , PALMA, John, F.
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2800/54
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23.发明授权A high sensivity multiparameter method for rare event analysis in a biological sample 有权生物样品中稀有事件的分析，高灵敏度多参数方法
公开(公告)号：EP2169387B1
公开(公告)日：2015-04-22
申请号：EP09251888.5
申请日：2009-07-28
IPC分类号： G01N33/50 , G01N21/64 , G01N33/569 , G01N33/574 , G01N33/58
CPC分类号： G01N21/6428 , G01N21/6458 , G01N33/5091 , G01N33/5094 , G01N33/569 , G01N33/57488 , G01N33/582 , G01N2021/6441
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24.发明授权INCREASED SEPARATION EFFICIENCY VIA CONTROLLED AGGREGATION OF MAGNETIC NANOPARTICLES 有权受控聚集的磁性纳米粒子提高效率分离
公开(公告)号：EP1311820B1
公开(公告)日：2015-02-11
申请号：EP00950339.2
申请日：2000-07-14
IPC分类号： G01N33/574 , C12N15/10 , G01N33/543
CPC分类号： G01N33/57492 , C12N15/1013 , G01N33/54326
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25.发明授权Methods and uses for identifying the origin of a carcinoma of unknown primary origin 有权方法和用途用于鉴定未知原发起源的癌症的起源
公开(公告)号：EP2402758B1
公开(公告)日：2014-09-10
申请号：EP11163930.8
申请日：2006-09-19
IPC分类号： G01N33/574 , G01N33/48 , C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/5091 , G16H10/40 , Y02A90/26
摘要： The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the algorithm or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
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公开(公告)号：EP3422848A1
公开(公告)日：2019-01-09
申请号：EP17712583.8
申请日：2017-03-03
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27.发明公开
公开(公告)号：EP3211086A3
公开(公告)日：2017-11-08
申请号：EP17163260.7
申请日：2006-09-20
发明人： CONNELLY, Mark, Carle , FOULK, Brad , KAGAN, Michael, T. , SWENNENHUIS, Joost, F. , TERSTAPPEN, Leon, W.M.M. , TIBBE, Arjan, G.J. , VERRANT, John, A.
CPC分类号： C12Q1/6886 , C12Q1/34 , C12Q1/6811 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2533/101 , C12Q2531/113 , C12Q2521/301 , C12Q2563/131 , C12Q2563/103
摘要： A method for detecting the presence of a target sequence comprising:
a. adding a probe, said probe having been produced by a method comprising:
i. obtaining double strand polynucleotides known to contain complementary target sequences and repetitive sequences;
ii. fragmenting said double strand polynucleotides into fragments;
iii. denaturing said fragments into single strands;
iv. hybridizing said repetitive sequences to form a mixture of double strands and single strands;
v. cleaving said double strands; and
vi. amplifying said single strands wherein said single strands are complementary to said target sequences; and
b. detecting said probe wherein said detection is selected from a group consisting of ISH, FISH, CGH, spectral karyotyping, chromosome painting, Northern blots, Southern blots, microarray analysis, and combinations thereof.-
公开(公告)号：EP2814985A2
公开(公告)日：2014-12-24
申请号：EP13749733.5
申请日：2013-02-13
发明人： WANG, Haiying , JIANG, Yuqiu , WANG, Yixin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2525/186 , C12Q2537/163
摘要： The disclosed edge-blocker oligonucleotide based AS-NEPB-PCR method amplifies allele specific DNA (or RNA) while dramatically blocking amplification of wild type (WT) DNA (or RNA). The AS-NEPB-PCR design allows ready modification of an existing PCR reaction setup with an edge-blocker oligonucleotide together with an allele specific primer complementary to the mutant sequence to achieve allele specific amplification. The method simplifies assay optimization procedures and achieved sensitivity sufficient to detect a signal present at 0.1% level with close to 100% specificity, which is useful in detecting SNP or genetic mutations. The method was used to detect three different genetic mutations in cancer, in KRAS, BRAF, and EGFR, with three different types of modified edge-blocker oligonucleotides (phosphate, inverted dT and amino-C7). It was possible to detect one copy of mutant DNA in 1000-copy of normal DNA background of a heterogeneous sample, and was far more sensitive than the other blocking method.
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公开(公告)号：EP2333112B1
公开(公告)日：2014-07-02
申请号：EP10178199.5
申请日：2005-02-18
发明人： Wang, Yixin
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
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30.发明公开ASSAY TO CAPTURE AND DETECT CIRCULATING MULTIPLE MYELOMA CELLS FROM BLOOD 审中-公开检测方法和识别各种循环骨髓瘤细胞从血液中的
公开(公告)号：EP2734307A1
公开(公告)日：2014-05-28
申请号：EP12740854.0
申请日：2012-07-20
摘要： The invention includes methods for isolating circulating multiple myeloma cells as well as method of treating patients suspected of having diseases of abnormal plasma cells.
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