摘要:
This optical soil survey devices comprise two parts, a soil excavation unit, which goes under the surface and excavates it and a sensing unit attached to the rear portion of the excavation u nit, which collects the data. The present invention provides a particular design of an optical soil survey device, whereby the sensing unit is mounted on the excavation unit such that the lower part of the sensing unit penetrates the soil below the lower part of the excavation unit. When using such a survey device the sensing unit penetrates the trench bottom that was opened by the excavation unit, assuring that the lower part of the sensing unit is continuously submerged in the soil. In a second object the invention provides a sensing unit specially designed for penetrating the trench bottom and for preparing the bottom of the obtained trench for optical surveying.
摘要:
The present invention relates to a new kind of foil bearing. The present invention relates to a bearing comprising a flexible foil (1) with a self-aligning mechanism (5, 11). The present invention furthermore relates to a foil bearing enabling a linear and/or rotary movement along/around an axis (i.e. a shaft). The present invention also relates to a foil gas/air bearing with a self-aligning mechanism (5, 11). The present invention furthermore relates to the use of said foil bearing in machines, more specifically in precision and/or high-speed machines and in high-speed precision spindles.
摘要:
The present invention relates to analogues of vitamin D namely 14-epi-2-alkyl-19-nor vitamin D derivatives. Also a general method for the synthesis and the biological activities are described. The general formula is: (I) where R (α or β oriented) represents an alkyl substituent and X part of a typical side chain of vitamin D or of one of its established analogues.
摘要:
The essence of the invention is the use of supercooled superconductors for generation of high-frequency electric oscillations. The superconductor is supercooled, i.e. in the normal phase at a temperature lower than the critical transition temperature for superconductivity, under an applied electric energy source. In such non equilibrium conditions the superconductor can have negative differential conductivity which can be used as an active medium in generators of electric ( current and voltage) oscillations. Such generators can be used in the superconducing electronics. Oscillation can be modulated by the change of bias voltage, electrostatic doping by a gate electrode, or by light. When small amplitude oscillations are stabilized near to the critical temperature the generator can be used as a bolometer. The supercooled superconductors can be used also as transistors and frequency mixers. The negative differential conductivity of superconductor is created by the excess conductivity of fluctuation Cooper pairs. This behavior is predicted by the solution of the Boltzmann kinetic equation of the metastable in the normal phase Cooper pairs. Boltzmann equation for fluctuation Cooper pairs is derived as a state-of-the-art application of the microscopic theory of superconductivity.
摘要:
The present invention relates to genetic diagnosis and therapy of diseases of the nervous system (NS). More particularly, it relates to methods to induce neural precursor cells (NPCs) and to the identification of a domain that determines the functionality of polypeptides belonging to the atonal family, and its use in therapy for the treatment of deafness, partial hearing loss and vestibular defects due to damage of loss of inner ear hair cells. Alternatively, the domain may be used in the treatment of cancer.
摘要:
The field of the invention relates to the use of carbohydrate binding compounds as a medicine, their use to treat or prevent viral infections, their use to manufacture a medicine to treat or prevent viral infections and their use in a vaccination strategy. The present invention relates to the use of said compounds to manufacture a medicine to treat or prevent viral infections of subjects, more in particular infections with viruses having glycosilated envelop proteins such as Retroviridae (i.e. Lentivirinae), like HIV (human immunodeficiency virus), Flaviviridae, like HCV (hepatitis C virus), Hepadnaviridae, like HEV (hepatitis B virus), Coronaviridae, like SARS corona virus, and Orthomyxoviridae, like influenza A, B or C.
摘要:
This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R1-R3 are as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for treating and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H- phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and R1 is selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and C1-6haloalkyl group.
摘要:
The present invention relates to the use of modified nucleotides and single or double stranded oligonucleotides comprising at least one of said modified nucleotides for performing RNA interference. The modified nucleotides are selected from 6-membered ring containing nucleotides such as hexitol, altritol, O-subsituted or O-alkylated altritol, cyclohexenyl, ribo-cyclohexenyl and O-subsituted or O-alkylated ribo-cyclohexenyl nucleotides. The present invention also relates to novel modified nucleosides or nucleotides and to the use of said novel modified nucleosides and nucleotides in single or double stranded oligonucleotides for RNA interference, antisense therapy or other applications.