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公开(公告)号：EP2888228B1
公开(公告)日：2019-04-24
申请号：EP13756096.7
申请日：2013-08-27
申请人： Ludwig-Maximilians-Universität München , Maastricht University , Academisch Ziekenhuis Maastricht
IPC分类号： C07C251/24 , C07C251/26 , C07D307/52 , C07D333/22 , A61P19/00 , A61P17/00
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22.发明授权
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公开(公告)号：EP3448870A1
公开(公告)日：2019-03-06
申请号：EP17725516.3
申请日：2017-04-27
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公开(公告)号：EP2684873B1
公开(公告)日：2019-01-16
申请号：EP13176579.4
申请日：2009-06-09
申请人： Ludwig-Maximilians-Universität München , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Giese, Armin , Bertsch, Uwe , Kretzschmar, Hans , Habeck, Matthias , Hirschberger, Thomas , Tavan, Paul , Griesinger, Christian , Leonov, Andrei , Ryazanov, Sergey , Frick, Petra , Geissen, Markus , Groschup, Martin, H. , Wagner, Jens
IPC分类号： C07D231/06 , C07D231/12 , C07D233/22 , C07D261/08 , C07D271/06 , C07D405/04 , C07D207/333 , A61K31/415 , A61P25/28
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公开(公告)号：EP3411496A1
公开(公告)日：2018-12-12
申请号：EP17702653.1
申请日：2017-02-06
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6874 , C12Q2521/501 , C12Q2563/107 , C12Q2563/179 , C12Q2565/518
摘要： The present invention relates to methods of determining the sequence of nucleotides in target nucleic acid molecules. Thus, the invention relates to methods of sub-unit sequencing. The methods comprise the use of identification nucleic acid detection entities which specifically hybridize to the target nucleic acid, bind identification tags and have localization tags transiently bind thereto.
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26.发明公开
公开(公告)号：EP3365331A1
公开(公告)日：2018-08-29
申请号：EP16797464.1
申请日：2016-10-21
IPC分类号： C07D271/10 , C07C243/38
摘要： The invention relates to 5,5'-bis(2,4,6-trinitrophenyl)-2,2'-bi(1,3,4-oxadiazole) and bis(2,4,6-trinitrobenzoyl)oxalohydrazide, an energetic active mass comprising or consisting of 5,5'-bis(2,4,6-trinitrophenyl)-2,2'-bi(1,3,4-oxadiazole) and/or bis(2,4,6-trinitrobenzoyl)oxalohydrazide, a use of 5,5'-bis(2,4,6-trinitrophenyl)-2,2'-bi(1,3,4-oxadiazole) as explosive, a use of bis(2,4,6-trinitrobenzoyl)oxalohydrazide as explosive as well as methods for synthesizing 5,5'-bis(2,4,6-trinitrophenyl)-2,2'-bi(1,3,4-oxadiazole) and bis(2,4,6-trinitrobenzoyl)oxalohydrazide.
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公开(公告)号：EP3334685A1
公开(公告)日：2018-06-20
申请号：EP16745731.6
申请日：2016-07-29
申请人： Bein, Thomas , Engelke, Hanna , Feckl, Johann , Freiherr von Schirnding, Constantin , Ludwig-Maximilians-Universität München
CPC分类号： A61K9/5115 , A61K9/1272 , A61K47/02 , A61K47/12 , A61K47/186 , A61K47/24 , A61K47/42 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B25/32 , C01P2004/64 , C01P2006/12 , C01P2006/14 , C01P2006/16 , C02F1/288 , C05B17/00
摘要： The present invention relates to mesoporous calcium phosphate-citrate nanoparticles, optionally comprising a lipid membrane, and pharmaceutical compositions thereof. The present invention further relates to a method of synthesizing the mesoporous calcium phosphate-citrate nanoparticles. The present invention relates to their use as drug delivery system. The present invention further relates to medical uses as bone or teeth cement, bone material or taste or non-taste masked carrier or delivery system. The present invention relates to the use of the mesoporous calcium phosphate-citrate nanoparticles in the diagnosis and/or treatment of cancer. The present invention further relates to the use of the mesoporous calcium phosphate-citrate nanoparticles in fertilizer or absorber of metal ions from wastewater and/or water.
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公开(公告)号：EP2982766B1
公开(公告)日：2018-05-23
申请号：EP15181740.0
申请日：2011-08-05
发明人： DORNMAIR, Klaus , HOHLFELD, Reinhard , PRINZ, Jörg Christoph , SIEWERT, Katherina , KIM, Song-Min
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/569 , A61K39/00
CPC分类号： C12N15/1037 , A61K39/00 , C12Q1/6883 , C12Q2600/16 , G01N33/505 , G01N33/56977 , G01N2333/7051 , G01N2333/70539
摘要： The present invention relates to a method of identifying nucleic acid molecules encoding variable, hypervariable and/or joining regions of T cell receptor ² chains as well as to this method of the invention further comprising identifying the nucleic acid molecules encoding variable, hypervariable and/or joining regions of the matching T cell receptor ± chains. The present invention further relates to a primer or a set of primers as well as to a kit.
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29.发明授权
公开(公告)号：EP2871463B1
公开(公告)日：2018-02-21
申请号：EP14192873.9
申请日：2014-11-12
IPC分类号： G01N21/47 , G01N33/543
CPC分类号： G01N21/4788 , C12Q1/18 , G01N33/5029 , G01N2201/06113 , G01N2201/068
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30.发明公开
公开(公告)号：EP3217489A1
公开(公告)日：2017-09-13
申请号：EP16000571.6
申请日：2016-03-09
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Ludwig-Maximilians-Universität München
CPC分类号： G02F1/3511 , G02F1/21 , G02F1/3523 , G02F1/355 , G02F1/3556 , G02F2203/15 , H01S3/08059 , H01S3/1112
摘要： An optical component (10) for modulating a light field (1) incident on the optical component (10), in particular for modulating at least one of amplitude and phase of the light field (1) in dependency on the intensity (I) thereof, comprises a stack (11) of refractive layers (12, 13) being arranged on a substrate (14), being made of materials having a third-order nonlinearity, and having alternatingly varying refractive indices (n), including a linear contribution (no) and a non-linear contribution (n 2 ), and determining reflectance and transmittance spectra of the optical component, wherein the refractive layers (12, 13) are configured such that reflectance and transmittance of the optical component have a Kerr effect based dependency on the intensity (I) of the incident light field with n = no + I·n 2 , and the refractive layers (12, 13) are made of at least one of dielectric and semiconductor layers, wherein the non-linear contribution (n 2 ) is below 10 -12 cm 2 /W. Furthermore, a resonator device including the optical component, a method of modulating a light field using the optical component and a method of manufacturing the optical component are described.
摘要翻译： 一种用于调制入射到光学部件（10）上的光场（1）的光学部件（10），特别用于根据其强度（I）调制光场（1）的振幅和相位中的至少一个 包括布置在衬底（14）上的折射层（12,13）的堆叠（11），所述折叠层（12,13）由具有三阶非线性的材料制成并且具有交替变化的折射率（n），包括线性贡献 以及确定所述光学部件的反射率和透射率光谱，其中所述折射层（12,13）被配置为使得所述光学部件的反射率和透射率具有基于克尔效应的依赖性 n = no + I·n2的入射光场强度（I）和折射层（12,13）由介电层和半导体层中的至少一个制成，其中非线性贡献（n2）为 低于10-12平方厘米/瓦。 此外，描述了包括该光学部件的谐振器装置，使用该光学部件调制光场的方法以及制造该光学部件的方法。
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