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    ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
    21.
    发明授权
    ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE 有权
    ACYLOXYALKYLCARBAMAT-PRODRUGS，SYNTHESEVERFAHREN UND ANWENDUNG

    公开(公告)号：EP1660440B1

    公开(公告)日：2012-02-22

    申请号：EP04781926.3

    申请日：2004-08-20

    申请人： XenoPort, Inc.

    发明人： GALLOP, Mark, A. ,  YAO, Fenmei ,  LUDWIKOW, Maria, J. ,  PHAN, Thu ,  PENG, Ge

    IPC分类号： C07C271/22 ,  A61K31/195

    CPC分类号： C07C271/22 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/79 ,  C07D307/30 ,  C07D333/38

    摘要： The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof , methods of making prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

    摘要翻译： 本文的公开内容通常涉及（.plusmn。）4氨基3（4氯苯基）丁酸及其类似物的酰氧基烷基氨基甲酸酯前药，其药物组合物，制备（.plusmn。）4氨基3（4氯苯基）丁酸 其酸和类似物，其用于（.plusmn。）4氨基3（4氯苯基）丁酸及其类似物的前药的方法及其用于治疗或预防常见疾病和/或病症如痉挛和/或酸的药物组合物 反流疾病。 本文的公开内容还涉及适于口服给药的（.plusmn）4氨基3（4氯苯基）丁酸及其类似物的氨基氧基烷基氨基甲酸酯产物及其缓释口服剂型。