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21.发明授权A KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A PATIENT'S BLOOD OR PLASMA 有权KIT FOR测量凝血酶在血液或血浆样品的患者
公开(公告)号：EP1730299B1
公开(公告)日：2011-06-01
申请号：EP05729048.8
申请日：2005-03-30
发明人： VARADI, Katalin , TURECEK, Peter , KEIL, Brigitte , PEYRER-HEIMSTAETT, Sylvia , SCHWARZ, Hans-Peter
CPC分类号： A61K31/66 , C12Q1/56 , G01N33/86 , G01N2333/745
摘要： The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
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22.发明公开SOLID PHASE-BOUND ELASTASE-BINDING ASSAY FOR THE MEASUREMENT OF ALPHA1-ANTITRYPSIN ACTIVITY 有权固相BOUND弹性蛋白酶结合测试测量α1-抗ANTITRYPSINAKTIVITÄT
公开(公告)号：EP2715349A1
公开(公告)日：2014-04-09
申请号：EP12720103.6
申请日：2012-04-25
CPC分类号： G01N33/68 , G01N33/53 , G01N2333/8125 , G01N2333/966
摘要： The present invention relates to a method for the measurement of active alpha
1 -proteinase inhibitor (A1PI) in a sample, comprising the steps of binding elastase to a solid support, letting the A1PI contained in the sample bind to the solid phase-bound elastase, and detecting solid phase-bound A1PI with a detection reagent.-
23.发明公开STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL PH 审中-公开稳定价格在弱酸性免疫球蛋白和其它蛋白BY含水配方氯化钠pH至中性
公开(公告)号：EP2616091A1
公开(公告)日：2013-07-24
申请号：EP11764394.0
申请日：2011-09-16
发明人： BUTTERWECK, Harald,Arno , BAUER, Theresa, Friederike , HOFBAUER, Lucia , TESCHNER, Wolfgang , ZOCHLING, Oliver , SCHWARZ, Hans-Peter , MAYER, Christa , HASSLACHER, Meinhard
CPC分类号： A61K39/39591 , A61K9/0019 , A61K47/02 , A61K47/183
摘要： The present invention provides, among other aspects, storage stabile aqueous formulations of labile proteins at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing a labile therapeutic protein composition at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of labile proteins at mildly acidic to neutral pH useful for parenteral administration.
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24.发明授权RECOMBINANT VON WILLEBRAND FACTOR AS A MOLECULAR WEIGHT MARKER FOR MASS SPECTROMETRY ANALYSES 有权重组血管性血友病因子分子量标准进行质量分析
公开(公告)号：EP2374004B1
公开(公告)日：2012-12-05
申请号：EP09771643.5
申请日：2009-12-16
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , MUELLER, Roland , IVENS, Andreas , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
CPC分类号： G01N33/6851 , G01N2333/755 , H01J49/164
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公开(公告)号：EP2480198A2
公开(公告)日：2012-08-01
申请号：EP10759786.6
申请日：2010-09-21
CPC分类号： A61K38/4886 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , C12Y304/24087
摘要： The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.
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公开(公告)号：EP2445482A1
公开(公告)日：2012-05-02
申请号：EP10727539.8
申请日：2010-05-27
发明人： BRUCKSCHWAIGER, Leopold , SVATOS, Sonja , NÜRNBERGER, Julia , TESCHNER, Wolfgang , BUTTERWECK, Harald Arno , SCHWARZ, Hans-Peter , GUNDINGER, Thomas , KOELBL, Bernhard , GRAUSENBURGER, Reinhard , PLJEVLJAKOVIC, Azra
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
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27.发明公开MODIFIED RECOMBINANT FACTOR VIII AND VON WILLEBRAND FACTOR AND METHODS OF USE 审中-公开修饰的重组因子VIII和血管性血友病因子及使用方法
公开(公告)号：EP2222329A1
公开(公告)日：2010-09-01
申请号：EP08846717.0
申请日：2008-11-07
IPC分类号： A61K38/37 , A61K47/48 , C07K14/755
CPC分类号： A61K38/37 , A61K47/60 , A61K47/61 , C07K14/755 , C08G65/329 , C08H1/00 , C08L63/00 , C08L2203/02
摘要： The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.
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