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公开(公告)号：EP1406888A1
公开(公告)日：2004-04-14
申请号：EP02743260.8
申请日：2002-07-03
申请人： Grünenthal GmbH
IPC分类号： C07D307/32 , C07D405/12 , A61K31/341 , A61P23/00
CPC分类号： C07D307/33 , C07D405/12
摘要： The invention relates to substituted η-lactone compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.
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公开(公告)号：EP1406610A1
公开(公告)日：2004-04-14
申请号：EP02754819.7
申请日：2002-07-03
申请人： Grünenthal GmbH
IPC分类号： A61K31/365 , A61K31/416 , A61K31/4155 , A61K31/443 , A61K31/4709 , A61K31/473 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/517 , A61P3/10 , A61P25/16 , A61P25/28 , A61P31/10 , A61P35/00 , A61P29/00
CPC分类号： A61K31/443 , A61K31/365 , A61K31/4155 , A61K31/473 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/517
摘要： The invention relates to the use of substituted gamma-lactone compounds in the production of medicines for treating migraines, septic shock, neurodegenerative diseases, such as multiple sclerosis, Parkinsons, Alzheimers or Huntingdons disease, inflammations and related pain, cerebral ischaemia, diabetes, meningitis, arteriosclerosis, cancer, mycosis, or for healing wounds.
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23.发明授权SUBSTITUIERTE AMINO-FURAN-2-YL-ESSIGSAURE- UND AMINO-THIEN-2-YL-ESSIGSAURE-DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON MIGRAINE BZW. SCHMERZ 有权取代的氨基呋喃-2-基ESSIGSAURE-和氨基 - 噻吩基醋衍生物和它们用于治疗偏头痛或 PAIN
公开(公告)号：EP1341786B9
公开(公告)日：2009-08-05
申请号：EP01998547.2
申请日：2001-11-28
申请人： Grünenthal GmbH
IPC分类号： C07D409/12 , C07D407/12 , C07D405/12 , C07D307/68 , C07D307/42 , A61K31/443 , A61K31/4436 , A61K31/4155 , A61K31/341 , C07D307/54 , C07D333/24 , A61K31/44 , C07D333/28 , C07D307/56 , A61P29/02
CPC分类号： C07D307/56 , C07D307/54 , C07D307/68 , C07D333/24 , C07D405/12 , C07D409/12
摘要： The invention relates to substituted aminofuran-2-yl-acetic acid derivatives and substituted aminothien-2-yl-acetic acid derivatives of general formulae (I-A) and (I-B). The invention also relates to a method for the production thereof, medicaments containing the same, the use of said compounds for producing medicaments for treating, inter alia, pain and migraines, and pharmaceutical compositions containing the same.
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24.发明授权SUBSTITUIERTE 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN 有权取代的5,6,6a，11B四氢-7-氧杂-5-氮杂 - 苯并[c]芴-6-羧酸衍生物作为NMDA拮抗剂
公开(公告)号：EP1412361B1
公开(公告)日：2008-07-23
申请号：EP02764838.5
申请日：2002-08-05
申请人： Grünenthal GmbH
发明人： GERLACH, Matthias , PRZEWOSNY, Michael , ENGLBERGER, Werner, Günter , REISSMÜLLER, Elke , BLOMS-FUNKE, Petra , MAUL, Corinna , JAGUSCH, Utz-Peter
IPC分类号： C07D491/04 , A61K31/445 , A61K31/34 , A61P25/04 , A61P25/06 , A61P25/00
CPC分类号： C07D491/04
摘要： The invention relates to substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid derivatives, to methods for the production thereof, medicaments containing these compounds, and to their use for producing medicaments for certain indications, particularly for treating pain.
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25.发明授权ARZNEIMITTEL ENTHALTEND SUBSTITUIERTE 2-ARYL-AMINOESSIGSÄURE-VERBINDUNGEN UND/ODER SUBSTITUIERTE 2-HETEROARYL-AMINOESSIGSÄURE-VERBINDUNGEN 有权DRUGS含有取代的2-芳基羧酸化合物和/或取代的2- heteroarylaminoacetic酸CONNECTIONS
公开(公告)号：EP1596856B1
公开(公告)日：2006-12-13
申请号：EP04708352.2
申请日：2004-02-05
申请人： Grünenthal GmbH
IPC分类号： A61K31/343 , A61K31/381 , A61K31/39 , A61K31/385 , A61P29/00 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： A61K31/343 , A61K31/198 , A61K31/381 , A61K31/385 , A61K31/39
摘要： The invention relates to drugs containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds as well as to their use in the production of drugs.
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26.发明公开ARZNEIMITTEL ENTHALTEND SUBSTITUIERTE 2-HETEROARYL-AMINOESSIGSÄURE-VERBINDUNGEN 有权ARZNEIMITTEL ENTHALTEND SUBSTITUIERTE 2-HETEROARYL-AMINOESSIGS＆Auml; URE-VERBINDUNGEN
公开(公告)号：EP1596852A2
公开(公告)日：2005-11-23
申请号：EP04708322.5
申请日：2004-02-05
申请人： Grünenthal GmbH
IPC分类号： A61K31/195 , A61K31/343
CPC分类号： A61K31/381 , A61K31/343
摘要： The invention relates to drugs containing substituted 2-aryl-aminoacetic acid compounds and to their use in the production of drugs.
摘要翻译： 本发明涉及含有取代的2-芳基 - 氨基乙酸化合物的药物及其在药物生产中的用途。
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27.发明授权SUBSTITUIERTE 1,5-DIHYDROPYRROL-2-ON-DERIVATE WIRKSAM ALS NMDA-REZEPTOR-ANTAGONISTEN FÜR DIE BEHANDLUNG VON SCHMERZZUSTÄNDEN 有权取代1,5-二氢 - 吡咯-2-酮衍生物有效用作NMDA受体拮抗剂用于治疗疼痛病症的治疗
公开(公告)号：EP1200402B1
公开(公告)日：2005-09-14
申请号：EP00956273.7
申请日：2000-07-25
申请人： Grünenthal GmbH
IPC分类号： C07D207/44 , A61K31/40 , A61P29/00
CPC分类号： C07D207/44
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28.发明授权SUBSTITUIERTE C-FURAN-2-YL-METHYLAMIN- UND C-THIOPHEN-2-YL-METHYLAMIN-DERIVATE 有权取代的C - 呋喃-2-基 - 甲胺和C-噻吩-2-基 - 甲基胺衍生物
公开(公告)号：EP1392670B1
公开(公告)日：2005-07-20
申请号：EP02743057.8
申请日：2002-05-21
申请人： Grünenthal GmbH
发明人： MAUL, Corinna , PRZEWOSNY, Michael
IPC分类号： C07D307/68 , A61K31/341 , A61P29/02
CPC分类号： C07D307/68
摘要： The invention relates to substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine derivatives of general formula (I), a method for the production thereof, medicaments and pharmaceutical compositions containing said derivatives, and the use of the same for producing analgesics, for producing a local anaesthetic, an anti-arrhythmic agent, an anti-emetic agent, a nootropic agent and/or a medicament for the treatment and/or the prophylaxis of cardiovascular diseases, urinary incontinence, diarrhoea, pruritus and/or inflammations, and/or a medicament for treating depression, and/or the misuse of alcohol and/or drugs and/or medicines, and/or a medicament for increasing vigilance.
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29.发明公开SUBSTITUIERTE 1H-CHINOXALIN-2-ON-VERBINDUNGEN UND SUBSTITUIERTE 4-ARYL- UND 4-HETEROARYLCYCLOHEXAN-VERBINDUNGEN 审中-公开替代物1H-CHINOXALIN-2-ON-VERBINDUNGEN SUBSTITUIERTE 4-ARYL- UND 4-HETEROARYLCYCLOHEXAN-VERBINDUNGEN
公开(公告)号：EP1444212A1
公开(公告)日：2004-08-11
申请号：EP02785285.4
申请日：2002-10-23
申请人： Grünenthal GmbH
发明人： SATTLEGGER, Michael , BUSCHMANN, Helmut , PRZEWOSNY, Michael , ENLGBERGER, Werner , KOEGEL, Babette-Yvonne , SCHICK, Hans
IPC分类号： C07D241/44 , A61K31/498 , C07C215/44 , C07C35/14 , A61P25/04
CPC分类号： C07D241/44 , C07C43/23 , C07C45/59 , C07C49/753 , C07C215/64 , C07C217/74 , C07C2601/14
摘要： The invention relates to substituted (1H)-quinoxalin-2-one compounds, methods for production thereof, medicaments containing said compounds and the use of said compounds for the production of medicaments. The invention further relates to substituted 4-aryl- and 4-heteroarylcyclohexane compounds and methods for production thereof.
摘要翻译： 本发明涉及取代的（1H）喹喔啉-2-酮化合物，其制备方法，含有所述化合物的药物和所述化合物用于制备药物的用途。 本发明还涉及取代的4-芳基 - 和4-杂芳基环己烷化合物及其制备方法。
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公开(公告)号：EP1442021A1
公开(公告)日：2004-08-04
申请号：EP02782979.5
申请日：2002-10-23
申请人： Grünenthal GmbH
发明人： SATTLEGGER, Michael , BUSCHMANN, Helmut , PRZEWOSNY, Michael , ENGLBERGER, Werner , KOEGEL, Babette-Yvonne , SCHICK, Hans
IPC分类号： C07D215/22 , A61K31/4704 , A61P25/04
CPC分类号： C07D215/22
摘要： The invention relates to substituted 1h-quinolin-2-one compounds, methods for production thereof, medicaments containing said compounds and use of said compounds for the production of medicaments.
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