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29 条记录 (耗时 0.015 秒)

    Octahydroindolo-[2,3-a]quinolizin-l-yl-alkanecarboxylic acid amides and salts thereof
    27.
    发明公开
    Octahydroindolo-[2,3-a]quinolizin-l-yl-alkanecarboxylic acid amides and salts thereof 失效
    OCTAHYDROINDOLO-Û2,3-A-喹诺酮-L-缬氨酸羧基酰胺及其盐

    公开(公告)号：EP0177361A3

    公开(公告)日：1987-09-02

    申请号：EP85307113

    申请日：1985-10-04

    申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

    发明人： Soti, Ferenc ,  Szantay, Csaba ,  Incze, Maria ,  Balogh, Zsuzsanna ,  Ezer, Elemer ,  Matuz, Judit ,  Szporny, Laszlo ,  Hajos, Gyorgy ,  Kuthi, Csaba

    IPC分类号： C07D471/14 ,  A61K31/395 ,  C07D221/00 ,  C07D209/00

    CPC分类号： C07D471/14

    摘要： The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),
    wherein
    R, and R 2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C 1-4 alkoxy group; R 3 and R 4 represent a hydrogen atom or a C 1-4 alkyl group; R 5 and R 6 represent a hydrogen atom, C 1-8 alkyl group, C 3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; or R 5 and R 6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; and G means a C 1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for preparing these compounds and compositions. The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.

    Alkylaminofuranone derivatives
    28.
    发明公开
    Alkylaminofuranone derivatives 失效
    烷基氨基呋喃酮衍生物

    公开(公告)号：EP0192393A2

    公开(公告)日：1986-08-27

    申请号：EP86300895.9

    申请日：1986-02-10

    申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

    发明人： Fodor, Tamas ,  Dobay, Laszlo ,  Fischer, Janos ,  Stefko, Bela ,  Kiss, Bela ,  Szombathelyi, Zsolt ,  Karpati, Egon ,  Laszlovszky, Istavan ,  Szporny, Laszlo

    IPC分类号： C07K5/06 ,  A61K37/02

    CPC分类号： C07K5/0222 ,  A61K38/00 ,  Y02P20/55

    摘要： The present invention relates to a compound of formula (I)
    wherein

    R' represents methyl or a group of the formula R 3 -NH-/CH 2 ) 4 - wherein R 3 is hydrogen or a protective group compatible with the peptide bond,
    R 2 represents hydrogen, a protective group compatible with the peptide bond or a cation derived from an organic or inorganic base; pharmaceutically acceptable salts and diastereomers thereof.

    The compounds of the invention are useful for inhibiting the effect of the angiotensin-converting enzyme and they can be used in therapy as blood pressure reducing agents and for the treatment of cardiac failure and glaucoma.

    摘要翻译： 本发明涉及式（I）化合物，其中R'代表甲基或式R3-NH- / CH2）4-基团，其中R3是氢或与该肽键相容的保护基，R2代表氢， 与肽键相容的保护基或衍生自有机或无机碱的阳离子; 其药学上可接受的盐和非对映体。 本发明化合物可用于抑制血管紧张素转化酶的作用，它们可用作降血压药物的治疗剂和治疗心力衰竭和青光眼。

    Fodder additive and a process for the preparation thereof
    29.
    发明公开
    Fodder additive and a process for the preparation thereof 失效
    其生产的动物饲料添加剂和方法。

    公开(公告)号：EP0179662A2

    公开(公告)日：1986-04-30

    申请号：EP85307686.7

    申请日：1985-10-24

    申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

    发明人： Perjes, Istvan ,  Selmeczi, Andras ,  Klebovich, Imre ,  Hajos, Gyorgy ,  Simon, Ferenc ,  Misley, Atilla ,  Szporny, Laszlo ,  Vereczkey, Laszlo ,  Toth, Edit ,  Torley, Jozsef ,  Sarkozy, Peter

    IPC分类号： A23K1/16

    CPC分类号： A23K50/30 ,  A23K20/111

    摘要： The invention relates to fodder additives comprising a compound inducing the microsomal enzyme system of the liver, such as a compound of the formula (I)
    wherein

    R i , R 2 and R 3 which may be the same or different represent hydrogen, halogen, trihalomethyl, or alkyl or alkoxy group each containing from 1 to 6 carbon atoms;
    R 4 is phenyl, dialkylaminocarbonyl or alkoxycarbonyl having from 1 to 6 carbon atoms in the alkyl and alkoxy moieties, respectively;
    R 5 is hydrogen or methyl, or together with R 4 and the nitrogen atom to which they are attached forms a heterocyclic ring having up to 8 members;
    n is an integer 1, 2, 3, 4 or 5;
    m is 0 or 1;
    a is 0 or 1,

    with the proviso that if a = 0, R 1 is trihalomethyl and R 2 and R 3 both are hydrogen. The compounds are preferably used in amount of 0.5 to 99% by weight, in admixture with a conventional carrier and/or additive and optionally at least one further active ingredient conventionally used in the animal husbandry.
    The enzyme-inducing compounds used according to the invention accelerate the elimination of various xenobiotics metabolizing in the iiver.