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29 条记录 (耗时 0.042 秒)

    SOLUBLE HYBRID Fc RECEPTORS AND RELATED METHODS
    23.
    发明公开
    SOLUBLE HYBRID Fc RECEPTORS AND RELATED METHODS 有权
    LÖSLICHEHYBRID-Fc gamma-REZEPTOREN UND ENTSPRECHENDE VERFAHREN

    公开(公告)号：EP2313105A1

    公开(公告)日：2011-04-27

    申请号：EP09771227.7

    申请日：2009-06-29

    申请人： ZymoGenetics, Inc.

    发明人： BIRKS, Carl, W. ,  FOX, Brian, A. ,  RIXON, Mark, W. ,  ELLSWORTH, Jeff, L.

    IPC分类号： A61K38/17 ,  C07K14/705

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/70535

    摘要： Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.

    摘要翻译： 提供了分离的可溶性多肽，其包含与选自SEQ ID NO：40的氨基酸残基36-301的多肽区域具有至少90％序列同一性的氨基酸序列; SEQ ID NO：42的氨基酸残基43-310; SEQ ID NO：44的氨基酸残基21-286; 或SEQ ID NO：46的氨基酸残基21-286; 其中所述多肽能够特异性结合IgG的Fc区。

    METHOD FOR PREPARING TRIMERIC PROTEINS
    25.
    发明公开
    METHOD FOR PREPARING TRIMERIC PROTEINS 有权
    方法产生蛋白质三聚体

    公开(公告)号：EP1960525A2

    公开(公告)日：2008-08-27

    申请号：EP06803300.0

    申请日：2006-09-11

    申请人： Zymogenetics, Inc.

    发明人： MOORE, Margaret, D. ,  FOX, Brian, A.

    IPC分类号： C12N15/63

    CPC分类号： C12N15/62 ,  A61K38/00 ,  C07K14/005 ,  C07K14/705 ,  C07K2319/03 ,  C07K2319/81 ,  C12N2740/10022 ,  C12N2740/13022

    摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.

    DIMERIZED GROWTH FACTOR AND MATERIALS AND METHODS FOR PRODUCING IT
    26.
    发明授权
    DIMERIZED GROWTH FACTOR AND MATERIALS AND METHODS FOR PRODUCING IT 有权
    二聚生长因子和材料及其制备方法

    公开(公告)号：EP1446478B1

    公开(公告)日：2008-01-23

    申请号：EP02773824.4

    申请日：2002-10-18

    申请人： ZymoGenetics, Inc.

    发明人： MOORE, Margaret, D. ,  FOX, Brian, A.

    IPC分类号： C12N5/10 ,  C12N15/16 ,  C12N15/63 ,  C07K14/47 ,  C07K14/575

    CPC分类号： C07K14/49 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

    摘要： Proteins consisting of two PDGF-D polypeptide chains, polynucleotides encoding the polypeptides, and materials and method for making the proteins are disclosed. Each of the polypeptide chains consists of, from amino terminus to carboxyl terminus, the following operably linked segments: P1-P2-h-CH2-CH3; P1-P2-CH2-CH3; h-CH2-CH3-P2-P1; or CH2-CH3-P2-P1. Within these polypeptide chains, P1 is a first polypeptide segment as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive; P2 is a second polypeptide segment consisting of from 4 to 20 amino acid residues; h is an immunoglobulin hinge region or portion thereof; and CH2 and CH3 are CH2 and CH3 domains of an immunoglobulin heavy chain, respectively. Within the protein, the two polypeptide chains are joined by one or more disulfide bonds, each of the chain is optionally glycosylated, and the protein binds to and activates cell-surface PDGF receptors.

    HUMAN CHEMOKINE-13
    29.
    发明公开
    HUMAN CHEMOKINE-13 审中-公开
    人趋化因子-13

    公开(公告)号：EP1478752A2

    公开(公告)日：2004-11-24

    申请号：EP01273880.3

    申请日：2001-11-14

    申请人： ZymoGenetics, Inc.

    发明人： FOX, Brian, A.

    IPC分类号： C12N15/19 ,  C07K14/52 ,  C07K16/24 ,  C07K16/42

    CPC分类号： C07K14/522 ,  A61K38/00 ,  C07K14/521 ,  C07K2319/02

    摘要： Chemokines are implicated in inflammation, ischemia and reperfusion injury, wound healing, allergies, as well as bacterial and viral pathogenesis. Moreover, chemokines may be involved in chronic diseases such as arthritis, asthma, and arteriosclerosis. The present invention provides a new form of chemokine, designated as "Zchemo13".