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21.发明公开Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them 审中-公开表位标签对T细胞受体的蛋白质，其为宿主细胞的选择用途和方法，其表达它们的表面上表达
公开(公告)号：EP1878744A1
公开(公告)日：2008-01-16
申请号：EP06014606.5
申请日：2006-07-13
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/177 , A61K48/00 , A61K2035/124 , A61K2039/5158 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/41 , C07K2319/43 , C12N15/62 , C12N15/79
摘要： The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.
摘要翻译： 本发明涉及一种方法，用于选择宿主细胞群表达功能性融合蛋白，其包含至少一个表位提供的氨基酸序列（表位标签）和蛋白质的氨基酸序列都被过表达，所述宿主的表面上 细胞。 优选地，所述氨基酸序列包含T细胞受体的α或β链的。 本发明还涉及在医学所述功能的T细胞受体（TCR）的α或β链融合蛋白的用途，在过继转移particulare。
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公开(公告)号：EP1594973A1
公开(公告)日：2005-11-16
申请号：EP04709610.2
申请日：2004-02-10
发明人： IVICS, Zoltán , IZSVAK, Zsuzsanna
CPC分类号： C12N15/90
摘要： The present invention relates to a targeting system comprising, preferably as distinct components (a) a transposon which is devoid of polynucleotide encoding a functional transposase comprising (aa) a polynucleotide of interest and; (ab) a DNA sequence specifically recognized by a DNA binding domain; and (ba) a fusion protein comprising (i) said DNA binding domain; or (ii) a (poly)peptide binding domain binding to a (poly)peptide comprising said DNA binding domain; and (iii) a DNA targeting domain; or (iv) a (poly)peptide binding domain that binds to a cellular or engineered (poly)peptide that comprises a DNA targeting domain; or (bb) a polynucleotide encoding the fusion protein of (ba); and (ca) a transposase or a fragment or derivative thereof having transposase function; or (cb) a polynucleotide encoding the transposase or fragment or derivative thereof having transposase function of (ca).
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23.发明公开METHOD FOR IDENTIFYING COMPOUNDS WHICH INHIBIT MECHANOTRANSDUCTION IN NEURONS 审中-公开一种识别物质，机械传导神经细胞INHIBIT
公开(公告)号：EP1556693A2
公开(公告)日：2005-07-27
申请号：EP03775263.1
申请日：2003-10-30
发明人： LEWIN, Gary , HEPPENSTALL, Paul , EILERS, Andreas
IPC分类号： G01N33/50
CPC分类号： G01N33/502 , G01N33/5008 , G01N33/5058 , G01N33/6872
摘要： Described is a method for identifying compounds which are capable of inhibiting mechanotransduction in neurons, compounds identified by such a method, pharmaceutical compounds containing the identified compounds and methods for treating pain. Also described is the use of stomatin domain-containing proteins for the identification of compounds which are capable of inhibiting mechanotransduction.
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公开(公告)号：EP2951202B1
公开(公告)日：2020-04-08
申请号：EP14702238.8
申请日：2014-01-29
IPC分类号： C07K14/725 , C07K16/30 , A61K39/395 , C12N15/13 , C12N15/12 , A61P35/00
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公开(公告)号：EP3194574A1
公开(公告)日：2017-07-26
申请号：EP15763506.1
申请日：2015-08-25
发明人： MARG, Andreas , SPULER, Simone
IPC分类号： C12N5/077
CPC分类号： C12N5/0659 , A61K35/34 , C12N2500/02 , C12N2523/00
摘要： The invention relates to method for cultivating stem cells in vitro, comprising the following steps: providing a sample comprising stem cells and cultivating the stem cells by subjecting the sample to a treatment for a first period of time. The treatment is carried out under hypothermic conditions having a defined temperature and a defined atmosphere, wherein the temperature does not exceed 15° C. and the atmosphere has an oxygen content not exceeding 21% (v/v). Thereby, the first period of time is 4 days to 4 weeks.
摘要翻译： 本发明涉及体外培养干细胞的方法，包括以下步骤：提供包含干细胞的样品，并通过对样品进行第一段时间的处理来培养干细胞。 该方法的特征在于，在具有限定温度和限定气氛的低温条件下进行处理，其中温度不超过15℃，并且气氛具有不超过21％（v / v）的氧含量。 从而，第一段时间是4天到4周。
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26.发明公开Method for the assessment of radiofrequency induced power absorption of conducting implants during MRI 审中-公开一种用于射频功率吸收的MRI期间引起由导电植入物的评价方法
公开(公告)号：EP2944972A1
公开(公告)日：2015-11-18
申请号：EP14001658.5
申请日：2014-05-12
CPC分类号： G01R33/288 , G01R33/285 , G01R33/48
摘要： The invention relates to a method for the assessment of radiofrequency induced power absorption, in particular heating of conducting implants, in particular intercoronary stents during magnetic resonance imaging by calculating a specific absorption rate (SAR) using a mathematical model, the model comprising a dependency of the absorption rate from a COS-function of the angular position between the long axis of the stent and the E-field-vector.
摘要翻译： 评价本发明，通过使用数学模型来计算特定吸收率（SAR）涉及一种用于射频感应功率吸收的评估的方法，在进行植入物的特定加热，在磁共振成像过程中的特殊intercoronary支架，该模型包括一个依赖 吸收速率从支架的长轴和E场矢量之间的角位置的COS函数。
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公开(公告)号：EP2258719A1
公开(公告)日：2010-12-08
申请号：EP09160679.8
申请日：2009-05-19
发明人： Blankenstein, Thomas, Prof. Dr. , Charo, Jehad, Dr. , Uckert, Wolfgang, Prof. Dr. , Kieback, Elisa , Perez, Cynthia
IPC分类号： C07K14/705 , C12N15/62 , A61K38/17 , A61P35/00
CPC分类号： C07K14/7051 , A61K38/00 , C07K2319/33
摘要： The present invention is directed to a functional T cell receptor (TCR) fusion protein (TFP) recognizing and binding to at least one MHC-presented epitope, and containing at least one amino acid sequence recognizing and binding an antigen. The present invention is further directed to an isolated nucleic acid molecule encoding the same, a T cell expressing said TFP, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.
摘要翻译： 本发明涉及识别并结合至少一种MHC-呈递的表位并含有至少一个识别和结合抗原的氨基酸序列的功能性T细胞受体（TCR）融合蛋白（TFP）。 本发明还涉及编码它的分离的核酸分子，表达所述TFP的T细胞和用于治疗涉及表达所述肿瘤相关抗原的恶性细胞的疾病的药物组合物。
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28.发明公开
公开(公告)号：EP2198008A1
公开(公告)日：2010-06-23
申请号：EP08838013.4
申请日：2008-10-10
CPC分类号： G01N33/56972 , A61K2035/122 , C12N5/0636
摘要： The present invention relates to methods for isolating human forkhead box P3 (Foxp3+) CD4+ regulatory T cells (herein referred to as Foxp3+ Treg cells) from a sample containing (i) peripheral blood mononuclear cells (PBMCs), (ii) a lymphocyte containing fluid, or (iii) a lymphocyte containing tissue, a kit for isolating human Foxp3+ Treg cells, and the use of anti-CD49d antibody for the isolation of human Foxp3+ Treg cells.
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29.发明公开Peptides having binding affinity to an antibody which recognizes an epitope on an alpha1 loop 2 or beta 2 loop 1 of an adrenoreceptor 审中-公开具有结合亲和性的识别在一个循环2或α1β2 - 肾上腺素受体的环路1的表位的抗体的肽
公开(公告)号：EP2080519A1
公开(公告)日：2009-07-22
申请号：EP08100510.0
申请日：2008-01-15
IPC分类号： A61K38/00 , A61K38/08 , A61P25/28 , C07K14/705 , C07K1/22
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
摘要： A peptide having an ED 50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED 50 value is measured by bioassay.
摘要翻译： 具有小于500纳米的ED 50在抗体，其识别的肽，特别是10nM至在细胞外±1环2或²2人类肾上腺素受体worin抗体的结合中的一个增加表位的结果的LOOP1表位上³ 分泌酶活性，以²-amyolid分子和/或脑血管细胞，神经胶质细胞或神经元的细胞功能障碍的释放增加，worin的ED 50值是通过生物测定法进行测定。
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30.发明公开USE OF POL III PROMOTERS FOR CONTROLLED EXPRESSION OF THERAPEUTIC PROTEINS 有权POL III启动子在治疗性蛋白的受控表达USE
公开(公告)号：EP1996713A2
公开(公告)日：2008-12-03
申请号：EP07723553.9
申请日：2007-03-20
发明人： CHARO, Jehad , BLANKENSTEIN, Thomas
IPC分类号： C12N15/867 , A61K48/00
CPC分类号： A61K48/0066 , C12N2799/027 , C12N2830/85
摘要： The present invention relates generally to the field of molecular biology. More specifically, the present invention relates to expression systems for use in modulating the expression of protein coding target genes in vivo or in vitro. More specific, this invention relates to RNA polymerase III-based methods and systems for expression of therapeutic proteins in cells in vivo or in vitro.
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