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125 条记录 (耗时 0.027 秒)

    STABILIZED BONE GRAFT
    21.
    发明公开
    STABILIZED BONE GRAFT 审中-公开
    稳定的骨移植

    公开(公告)号：EP1708651A1

    公开(公告)日：2006-10-11

    申请号：EP05712509.8

    申请日：2005-01-27

    申请人： Osteotech, Inc.,

    发明人： KNAACK, David ,  DIEGMANN, Michele ,  MANRIQUE, Albert

    IPC分类号： A61F2/28

    CPC分类号： A61L27/3608 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61K31/728 ,  A61K35/32 ,  A61K38/55 ,  A61L27/365 ,  A61L27/3695 ,  A61L2430/02 ,  B33Y80/00 ,  A61K2300/00

    摘要： A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol or hydrogels.

    摘要翻译： 提供通过降低组合物的pH值，降低水含量，添加水替代物和/或增加组合物中存在的氘化水的量来稳定的脱矿骨基质（DBM）或其他基质组合物，以便 降低内源性降解酶如蛋白酶的活性。 稳定的DBM组合物的水合形式在室温下在酸性pH下可以稳定至多一年。 酸化的DBM组合物可以通过加入稳定剂例如氘代水，水替代物，聚合物，蛋白酶抑制剂，甘油，水凝胶等进一步稳定。本发明还提供了制备，测试和使用本发明的稳定的骨诱导性 基质组合物。

    IMPROVED BONE MATRIX COMPOSITIONS AND METHODS
    22.
    发明公开
    IMPROVED BONE MATRIX COMPOSITIONS AND METHODS 有权
    改进的骨基质组合物的方法

    公开(公告)号：EP1701729A2

    公开(公告)日：2006-09-20

    申请号：EP04815984.2

    申请日：2004-12-31

    申请人： Osteotech, Inc.,

    发明人： BEHNAM, Keyvan ,  CIOFFI, Christopher

    IPC分类号： A61K35/32

    CPC分类号： A61K38/01 ,  A61L27/227 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/254 ,  A61L2300/412 ,  A61L2300/432 ,  A61L2430/02 ,  A61L2430/06 ,  Y10S623/901

    摘要： The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and/or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions. Ona assay comprises exposing relatively undifferentiated mesenchymal cells to a bone matrix composition and measuring expression of a marker characteristic of osteoblast or chondrocyte lineage(s). Increased expression of the marker relative to the level of the marker in cells that have been exposed to a control matrix (e.g., an inactivated or untreated matrix) indicates that the treatment or condition increased the osteogenic and/or chondrogenic activity of the bone matrix. Suitable cells include C2C12 cells. A suitable marker is alkaline phosphatase. The inventive methods increase the osteogenic and/or chondrogenic activity of human DBM when tested using this assay system.

    PRESSURE FLOW SYSTEM AND METHOD FOR TREATING A FLUID PERMEABLE WORKPIECE SUCH AS BONE
    27.
    发明授权
    PRESSURE FLOW SYSTEM AND METHOD FOR TREATING A FLUID PERMEABLE WORKPIECE SUCH AS BONE 失效
    水系是被迫和用于治疗透液性的工件，如骨

    公开(公告)号：EP0979109B1

    公开(公告)日：2003-11-19

    申请号：EP98911575.3

    申请日：1998-03-11

    申请人： Osteotech, Inc.,

    发明人： SCARBOROUGH, Nelson, L. ,  MORRIS, John, W. ,  RUSSELL, James, L. ,  DOWD, Michael

    IPC分类号： A61L27/00

    CPC分类号： A61F2/4644 ,  A61F2/28 ,  A61F2002/4646 ,  A61K35/32 ,  A61L2/0088 ,  A61L2/18 ,  A61L27/36 ,  A61L27/3608 ,  A61L27/3683 ,  Y10S623/923

    摘要： A pressure flow system and method for its use are provided for contacting the interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressure chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied to the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non-bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bone microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.