公开(公告)号：EP1945780B1

公开(公告)日：2015-09-16

申请号：EP06836301.9

申请日：2006-10-13

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： RUPPRECHT, Charles, E. ,  WU, Xianfu

IPC分类号： A61K39/12 ,  A61K39/205 ,  C12N7/00 ,  C12N15/86 ,  A61K39/00

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/205 ,  A61K2039/5254 ,  C12N15/86 ,  C12N2760/20134 ,  C12N2760/20143 ,  C12N2760/20161

公开(公告)号：EP2594584B1

公开(公告)日：2015-07-15

申请号：EP12198382.9

申请日：2009-01-30

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Dimitrov, Dimiter, S.

IPC分类号： C07K16/00 ,  C07K16/10 ,  C07K19/00

CPC分类号： C07K16/1063 ,  C07K16/005 ,  C07K16/1045 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2318/10 ,  C07K2318/20

公开(公告)号：EP2336174B1

公开(公告)日：2015-06-03

申请号：EP10180621.4

申请日：2005-11-04

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Dimitrov, Diviter S ,  Zhu, Zhongyu ,  Broder, Christopher C

IPC分类号： C07K16/10 ,  A61K39/395

CPC分类号： C07K16/1203 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/115 ,  G01N2469/10

公开(公告)号：EP2240201B1

公开(公告)日：2015-04-22

申请号：EP08863946.3

申请日：2008-12-16

申请人： The Government of The United States of America as represented by the Secretary of The Department of Health and Human Services, Centers for Disease

发明人： BIRD, Brian, H. ,  ALBARINO, Cesar, G. ,  NICHOL, Stuart, T. ,  KSIAZEK, Thomas, G.

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K35/76 ,  A61K39/00 ,  A61K2039/525 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/12211 ,  C12N2760/12221 ,  C12N2760/12234 ,  Y02A50/397

摘要： Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.

公开(公告)号：EP2197903B9

公开(公告)日：2015-04-22

申请号：EP08799197.2

申请日：2008-09-04

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： PASTAN, Ira, H. ,  WELDON, John ,  FITZGERALD, David

IPC分类号： C07K14/21 ,  C07K19/00 ,  C12N15/62 ,  C12N15/11 ,  A61K38/16

CPC分类号： C07K14/21 ,  A61K38/00 ,  C07K2319/30

公开(公告)号：EP2559772B1

公开(公告)日：2015-04-15

申请号：EP12179592.6

申请日：2008-06-09

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services ,  The Ohio State University Research Foundation

发明人： Wang, Xin Wei ,  Ji, Junfang ,  Yamashita, Taro ,  Croce, Carlo, M.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/6893

公开(公告)号：EP2292802B1

公开(公告)日：2015-01-14

申请号：EP10181804.5

申请日：2002-05-22

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Whitehead, Stephen, S. ,  Murphy, Brian, R. ,  Hanley, Kathryn, A. ,  Blaney, Joseph, E., Jr. ,  LAI, Ching-Juh

IPC分类号： C12Q1/70 ,  C12N7/00 ,  C12N7/04 ,  C12P19/34 ,  G01N33/53 ,  G01N33/48 ,  A61K39/12 ,  A61K39/42 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K39/12 ,  A61K39/295 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/575 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/24121 ,  C12N2770/24134 ,  C12N2770/24161 ,  C12N2770/24162 ,  C12N2770/24171 ,  C12Q1/701 ,  C12Q2600/156 ,  G01N2333/18 ,  G01N2500/10 ,  Y02A50/386

摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.

摘要翻译： 它开发没有突变的菜单是有用的微调登革病毒疫苗的衰减和生长特性。

公开(公告)号：EP2808384A2

公开(公告)日：2014-12-03

申请号：EP14168068.6

申请日：2005-10-07

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： Kew, Olen M. ,  Burns, Cara C. ,  Shaw, Jing ,  Campagnoli, Raymond ,  Quay, Jacqueline

IPC分类号： C12N5/10 ,  A61K39/00 ,  C12N15/67

CPC分类号： A61K39/0258 ,  A61K39/00 ,  A61K2039/522 ,  A61K2039/5254 ,  C07K14/245 ,  C12N7/00 ,  C12N15/67 ,  C12N2710/16162 ,  C12N2710/16662 ,  C12N2710/16762 ,  C12N2760/16162 ,  C12N2760/18462 ,  C12N2760/18562 ,  C12N2770/20062 ,  C12N2770/24162 ,  C12N2770/32162 ,  C12N2770/32762 ,  C12N2770/36262 ,  Y02A50/466 ,  Y02A50/472 ,  Y02A50/476

摘要： Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

摘要翻译： 公开了产生复制适应性降低的病原体的方法，以及使用所述方法产生的减毒病原体。 在特定的例子中，该方法包括去编码编码序列中的一个或多个密码子，由此降低病原体的复制适合性。 还公开了使用减毒病原体作为免疫原性组合物的方法。

公开(公告)号：EP2358684B8

公开(公告)日：2014-10-22

申请号：EP08876356.0

申请日：2008-10-20

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services ,  Forschungsverbund Berlin e.V.

发明人： GERSHENGORN, Marvin, C. ,  NEUMANN, Susanne ,  RAAKA, Bruce, M. ,  THOMAS, Craig, J. ,  INGLESE, James ,  SOUTHALL, Noel, T. ,  TITUS, Steven ,  ZHENG, Wei ,  HUANG, Wenwei ,  KRAUSE, Gerd ,  KLEINAU, Gunnar

IPC分类号： C07D401/06 ,  C07D405/06 ,  C07D239/91 ,  C07D487/04

CPC分类号： C07D405/06 ,  A61K31/517 ,  A61K49/0004 ,  A61K51/00 ,  C07D239/91 ,  C07D401/06 ,  C07D405/14 ,  C07D487/04

公开(公告)号：EP2768847A1

公开(公告)日：2014-08-27

申请号：EP12841016.4

申请日：2012-10-18

申请人： The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services

发明人： CHANG, Gwong-jen, J. ,  CRILL, Wayne, D. ,  HUGHES, Holly, R. ,  DAVIS, Brent, S.

IPC分类号： C07K14/18 ,  C12N15/40 ,  A61K39/12 ,  A61K39/295

CPC分类号： A61K39/12 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6075 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24123 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24171 ,  Y02A50/386

摘要： Described herein are dengue virus E-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes associated with immune enhancement. The disclosed dengue virus E-glycoproteins optionally further include mutations that introduce a strong CD4 T cell epitope. The disclosed E-glycoprotein polypeptides, or nucleic acid molecules encoding the polypeptides, can be used, for example, in monovalent or tetravalent vaccines against dengue virus. The dengue virus E-glycoprotein polypeptides have amino acid substitutions at residues corresponding to position 106, 107, 310 and 311, and either position 364 or position 389 of dengue serotype 1 (DENV-1) E-glycoprotein. The provided E-glycoprotein polypeptides optionally further include mutations corresponding to positions 468, 478, 482 and 487 of DENV-1 E-glycoprotein.