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    PRECISELY-SHAPED CORE FIBERS AND METHOD OF MANUFACTURE
    21.
    发明授权
    PRECISELY-SHAPED CORE FIBERS AND METHOD OF MANUFACTURE 有权
    精密成形的芯纤维和制造方法

    公开(公告)号：EP2460036B1

    公开(公告)日：2017-06-28

    申请号：EP10781232.3

    申请日：2010-05-27

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： NEUBERGER, Wolfgang

    IPC分类号： G02B6/028 ,  G02B6/02 ,  H01S3/067

    CPC分类号： G02B6/02 ,  H01S3/06729

    摘要： Non-circular core optical preforms are provided whose core-cladding interface edge has a sharpness that can be accurately controlled according to application-specific needs. Preform design and fiber fabrication is handled such that precisely edged fiber cores are maintained in the drawn fibers. This provides for markedly improved fiber functions, which rely on the non-circular structure of the core. In short, optical fibers having non-circular wave-guiding regions with precise, controlled edges are provided. By using selected manufacturing techniques that employ lower temperatures than commonly used, prior art techniques and by choosing proper materials with appropriate viscosities for core and cladding, the rounding of the edges of the wave-guiding region is precisely maintained in the final optical fibers.

    摘要翻译： 提供了非圆形芯光学预制棒，其芯 - 包层界面边缘具有可根据特定应用的需要精确控制的清晰度。 预成型件设计和纤维制造的处理使得精确修边的纤维芯被保持在拉伸的纤维中。 这提供了明显改进的光纤功能，其依赖于芯的非圆形结构。 简而言之，提供了具有精确的受控边缘的非圆形波导区域的光纤。 通过使用选择的制造技术，该技术采用比通常使用的现有技术更低的温度并通过选择具有适当的芯和包层粘度的合适材料，波导区域的边缘的圆化在最终的光纤中被精确地保持。

    FIBER OPTIC LIGHT SOURCE
    25.
    发明公开
    FIBER OPTIC LIGHT SOURCE 审中-公开
    光纤光源

    公开(公告)号：EP3279556A1

    公开(公告)日：2018-02-07

    申请号：EP17184972.2

    申请日：2017-08-04

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： Neuberger, Wolfgang ,  Solomatin, Alexey

    IPC分类号： F21V8/00 ,  G02B6/42 ,  H04B10/114

    CPC分类号： F21K9/64 ,  G02B6/0003 ,  G02B6/0006 ,  G02B6/0008 ,  G02B6/001 ,  G02B6/02076 ,  G02B6/0208 ,  G02B6/421 ,  G02B6/4214 ,  G02B27/0994 ,  H01S3/067 ,  H04B10/114 ,  H04B10/116

    摘要： A fiber optic light source in which input light with short and narrow band wavelength is converted/transformed into multi-band visible white light with high intensity output power is provided. The new light source comprises at least one homogenizing light guide element, and at least one photoluminescence element. It may also comprise at least one input element and an optical fiber. All or some of the elements may be integrated into an optical waveguide. In some embodiments the at least one input element increases light transfer efficiency from a ray source to the at least one homogenizing light guide element component of the fiber optic light source. The at least one photoluminescence element can be a point or an extended form like a line or surface. The fiber optic light source output beam may also contain the input ray wavelength, which in turn can be from a fiber optic laser. In operation an input ray travels through at least one homogenizing light guide element and irradiates at least one photoluminescence element present in preselected positions of the device to cause large area or spacious illumination at a desired target. This source can be an information source to communicate information through light modulation not noticeable to the naked human eye. Information is sent from the optical light source to information receivers, technical devices like smart phones, TV-Displays, or other devices, which could replace the common use of LAN or WLAN networks. Here a known luminescent detector can be used to efficiently collect the information in its optical form and to lead it to a suitable photo detector. This enables free-space optical light information transfer especially in areas where traditional infrastructure using transmitting fibers is difficult to establish.

    摘要翻译： 提供一种光纤光源，其中具有短波和窄波段波长的输入光被转换/变换成具有高强度输出功率的多波段可见白光。 新的光源包括至少一个均化光导元件和至少一个光致发光元件。 它也可以包括至少一个输入元件和光纤。 所有或一些元件可以被集成到光波导中。 在一些实施例中，所述至少一个输入元件增加从光源到光纤光源的至少一个均化光导元件部件的光传输效率。 该至少一个光致发光元件可以是像线或表面那样的点或扩展形式。 光纤光源输出光束也可以包含输入光线的波长，其又可以来自光纤激光器。 在操作中，输入射线穿过至少一个均化光导元件并且照射存在于装置的预选位置中的至少一个光致发光元件，以在期望的目标处引起大面积或宽敞的照明。 这个信息源可以作为一个信息来源，通过光线调制来传递信息，这对于肉眼来说并不明显。 信息从光源发送到信息接收器，技术设备如智能手机，电视显示器或其他设备，这些设备可以取代LAN或WL​​AN网络的常见用途。 这里可以使用已知的发光检测器来有效地收集其光学形式的信息并将其引导至合适的光电检测器。 这使得自由空间光信息传输成为可能，特别是在使用传输光纤的传统基础设施难以建立的地区。

    CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY
    28.
    发明公开
    CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY 审中-公开
    卟啉类光敏剂与甘油基聚合物共轭用于光动力疗法

    公开(公告)号：EP3210626A1

    公开(公告)日：2017-08-30

    申请号：EP17158001.2

    申请日：2017-02-24

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： STAEGEMANN, Michael ,  HAAG, Rainer ,  WIEHE, Arno ,  GRÄFE, Susanna ,  GITTER, Burkhard ,  ALBRECHT, Volker

    IPC分类号： A61K41/00 ,  C07D403/14 ,  A61P35/00

    CPC分类号： C07D487/22 ,  A61K41/0071 ,  A61K47/60 ,  C07D403/14 ,  C08G65/48

    摘要： Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. In addition, conjugates are provided in which these photosensitizers are attached to water-soluble polymers via cleavable linkers that can be cleaved in the body under specific conditions. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

    摘要翻译： 可用作诊断和治疗应用的光敏剂的生物活性化合物，特别是用于癌症的PDT，感染和其他过度增殖性疾病，非肿瘤性适应症如关节炎，炎性疾病，病毒或细菌感染的荧光诊断和PDT治疗， 提供皮肤病，眼科或泌尿系统疾病以及提供获得药物质量的方法。 此外，提供了这样的缀合物，其中这些光敏剂经由可在特定条件下在体内裂解的可切割连接物连接至水溶性聚合物。 另一个实施方案包括将所需的四吡咯光敏剂配制成药物制剂以注射到体内，避免不希望的效应，例如四吡咯系统的溶解度问题或延迟的药代动力学。