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公开(公告)号：EP2689796A1
公开(公告)日：2014-01-29
申请号：EP13189786.0
申请日：2009-12-15
申请人： ProFibrix BV
CPC分类号： A61M35/00 , A61M11/00 , A61M11/008 , A61M15/0008 , A61M35/003 , A61M2202/0425 , A61M2202/0449 , A61M2205/8225
摘要： A device (20) for the topical dispensing of a powder, typically a powder medicament, comprises, or is adapted to be coupled to, a powder receptacle (31) and a gasflow generator. The gasflow generator is adapted, in use, to cause gas to flow through the device (20), which further comprises an agitator by which the powder and/or the powder receptacle (31) can be mechanically agitated. Actuation of the gasflow generator, which causes gas to flow through the device (20) and to entrain powder from the powder receptacle (31), thereby to dispense powder from the device (20), is accompanied by actuation of the agitator, causing the powder receptacle (31) to be mechanically agitated, thereby facilitating the release of powder from the powder receptacle (31).
摘要翻译： 用于局部分配粉末（通常为粉末药物）的装置（20）包括或适于与粉末容器（31）和气流发生器耦合。 气流发生器在使用中适于使气体流过装置（20），该装置还包括搅拌器，粉末和/或粉末容器（31）可通过该搅拌器被机械搅拌。 伴随着搅拌器的致动，引起气体流过装置（20）并夹带来自粉末容器（31）的粉末从而从装置（20）分配粉末的气流发生器的致动，导致 粉末容器（31）被机械搅拌，从而有助于从粉末容器（31）释放粉末。
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22.发明公开LOW DENSITY LIPOPROTEIN/FIBRINOGEN ADSORBENT AND ADSORPTION APPARATUS CAPABLE OF WHOLE BLOOD TREATMENT 有权低密度脂蛋白/纤维蛋白原，吸附剂和设备全血治疗
公开(公告)号：EP1621220A4
公开(公告)日：2011-10-26
申请号：EP04729289
申请日：2004-04-23
申请人： KANEKA CORP
IPC分类号： A61M1/36
CPC分类号： A61M1/3633 , A61M2202/0449 , A61M2202/046 , A61M2202/0057
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公开(公告)号：EP0794824B1
公开(公告)日：2008-08-20
申请号：EP95942533.1
申请日：1995-12-01
申请人： Vivolution A/S
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要： A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added. The separation of fibrin monomer from the plasma fraction in the second chamber is carried out during continued centrifugation whereby a fibrin polymer is deposited on the cylindrical outer wall of said second chamber, whereafter the fluid fraction collected at the bottom of the second chamber is transferred while influenced by the piston body to the first chamber. The fraction with fibrin polymer remaining in the second chamber is substantially deposited on the cylindrical wall and is caused to be dissolved by addition of a solvent and by centrifugation, whereafter it is transferred to a receiving container by passing after addition of a binder to the enzyme through a filter removing said enzyme, whereby a fibrin monomer containing solution is provided.
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24.发明授权APPARATUS AND METHODS FOR PREPARING BLOOD OR PLASMA COMPONENT SOLUTIONS OF KNOWN CONCENTRATION 失效装置及其制造方法的血液或血浆现有解决方案已知浓度
公开(公告)号：EP0951642B1
公开(公告)日：2006-12-13
申请号：EP98904527.3
申请日：1998-01-08
CPC分类号： A61M1/3693 , A61M2202/0449 , B01D21/262 , B01D21/305 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要： An apparatus for separating e.g., a fibrin monomer from blood includes a container (110) with a reaction chamber defined by an outer wall for receiving plasma and a means for supplying the chamber with an agent for converting the fibrinogen content of the plasma into a non-cross-linked fibrin polymer. The apparatus includes a device for centrifuging the plasma and the agent within the chamber to a degree sufficient for separating the fibrin polymer from the plasma, depositing the polymer on the outer wall of the chamber and expelling the remaining plasma from the chamber. The container (110) includes means for supplying the chamber with a solvent for dissolving the fibrin polymer. The apparatus includes a measuring device (130) for measuring the amount of the deposit of the fibrin polymer on the outer wall of the container (110) and a control unit (131) for controlling the addition of solvent in response to the amount of polymer.
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25.发明公开Poche et procédé de défibrination utilisant un élément textile 有权Beutel und Defibrinierungsverfahren unter Verwendung eines Textilelements
公开(公告)号：EP1348456A1
公开(公告)日：2003-10-01
申请号：EP03290650.5
申请日：2003-03-14
申请人： MACO PHARMA
CPC分类号： A61M1/0209 , A61J1/10 , A61J1/1468 , A61J1/1487 , A61M1/0204 , A61M1/0218 , A61M1/025 , A61M1/3636 , A61M1/3672 , A61M1/3679 , A61M2202/0449 , A61M2202/0057
摘要： L'invention a pour objet une poche (1) destinée à la défibrination d'un fluide biologique tel que le sang ou le plasma sanguin, du type comprenant une enveloppe extérieure (2) formant un volume intérieur (6) pour ledit fluide, ladite enveloppe (2) étant munie d'au moins un orifice d'entrée (7) et/ou de sortie (8) du fluide, dans laquelle au moins un élément textile (9) apte à fixer la fibrine du fluide est disposé dans le volume intérieur (6).
L'invention concerne également un système à poches comprenant une telle poche, des procédés de défibrination ainsi que l'utilisation d'un élément textile (9) pour la défibrination d'un fluide biologique.摘要翻译： 设计用于对血液或血浆等生物流体进行去纤维化的袋（1）包括形成用于流体的内部容积（6）的外部外壳（2）。 信封具有用于流体的入口（7）和出口（8）。 设计成将纤维固定在流体中的织物元件（9）被放置在内部体积中，而不将其细分。 设计用于对血液或血浆等生物流体进行去纤维化的袋（1）包括形成用于流体的内部容积（6）的外部外壳（2）。 信封具有用于流体的入口（7）和出口（8）。 设计成将纤维固定在流体中的织物元件（9）被放置在内部体积中，而不将其细分。 纺织元件包括至少一个针织，机织或非织造层，并且由基于聚乙烯，聚丙烯，聚酯，聚酰胺，聚氨酯及其衍生物的聚合物或共聚物制成。 外部信封由两个围绕其周边组装的柔软塑料材料的两片叶子（3,3'）制成。 纺织元件固定在内部容积的外围的一部分上。 还包括以下独立权利要求：（1）设计用于对生物流体如血液或血浆进行取样和去纤维化的小袋系统，其包含如上所述的具有织物元件的初级流体接收袋。 第二流体接收袋通过第二管连接到来自主流体接收袋的出口，该第二管包含可以保持微槽的过滤器; 和（2）使用包含如上所述的织物元件的小袋的去纤维化处理，其中袋搅动一段时间，从而有效地消除流体中的所有纤维。 脱纤维的流体可以转移到通过密封和无菌手段连接到第一袋的第二袋。 停止搅动，使脱纤维血液滗出以分离血清和血细胞。
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26.发明公开METHODS FOR PREPARING BLOOD OR PLASMA COMPONENT SOLUTIONS WITH IMPROVED CONCENTRATIONS 有权方法HERSTELUNG与水平升高血液或血浆Components的解决方案
公开(公告)号：EP1242157A1
公开(公告)日：2002-09-25
申请号：EP00968544.7
申请日：2000-09-29
CPC分类号： A61M1/0209 , A61M1/3693 , A61M2202/0415 , A61M2202/0449 , B01D21/262 , B01D2221/10 , B04B2005/0485 , C07K14/75
摘要： A method for separating a blood component, e.g., fibrin monomer, from blood or plasma. The method utilizes a container with a reaction chamber for receiving the plasma. The reaction chamber is defined by a wall and an agent is supplied to the reaction chamber for converting the fibrinogen content of the plasma into a non-cross-linked fibrin polymer. The method also utilizes a device for centrifuging the reaction chamber with the plasma and the agent to a degree sufficient for separating the non-cross-linked fibrin polymer from the plasma, for depositing the polymer on the outer wall of the reaction chamber, and for expelling the remaining plasma from the reaction chamber. A solvent is supplied to the reaction chamber for dissolving the non-cross-linked fibrin polymer. The solvent is supplied to the reaction chamber in a first amount for dissolving the non-cross-linked fibrin polymer which is less than the total amount of solvent for dissolving the polymer. The remaining solvent is supplied to the reaction chamber in one or more portions to flush the reaction chamber and other portions of the device and recover additional non-cross-linked fibrin polymer.
摘要翻译： 一种用于分离血液成分，E. G.，血纤维蛋白单体，从血液或血浆的方法。 该方法利用与反应室的一个容器，用于接收等离子体。 反应室由壁限定和代理被提供到反应室中用于等离子体的纤维蛋白原含量转换成非交联的血纤维蛋白聚合物。 因此，该方法利用了一种用于离心与等离子体反应室和代理到足以用于从血浆中分离出的非交联的血纤维蛋白聚合物，用于沉积聚合物在反应室的外壁，以及用于 排出从所述反应室中的剩余的血浆。 的溶剂被供给到反应室，用于非交联的血纤维蛋白聚合物溶解。 溶剂被供给到反应室中的第一量的非交联的血纤维蛋白聚合物的所有小于溶剂的总量为溶解聚合物溶解。 将剩余的溶剂供给到反应腔室中的一个或多个部分来冲洗反应室和设备的其它部分和回收另外的非交联的血纤维蛋白聚合物。
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27.发明公开APPARATUS AND METHODS FOR PREPARING BLOOD OR PLASMA COMPONENT SOLUTIONS OF KNOWN CONCENTRATION 失效装置及其制造方法的血液或血浆现有解决方案已知浓度
公开(公告)号：EP0951642A1
公开(公告)日：1999-10-27
申请号：EP98904527.0
申请日：1998-01-08
CPC分类号： A61M1/3693 , A61M2202/0449 , B01D21/262 , B01D21/305 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要： An apparatus for separating e.g., a fibrin monomer from blood includes a container (110) with a reaction chamber defined by an outer wall for receiving plasma and a means for supplying the chamber with an agent for converting the fibrinogen content of the plasma into a non-cross-linked fibrin polymer. The apparatus includes a device for centrifuging the plasma and the agent within the chamber to a degree sufficient for separating the fibrin polymer from the plasma, depositing the polymer on the outer wall of the chamber and expelling the remaining plasma from the chamber. The container (110) includes means for supplying the chamber with a solvent for dissolving the fibrin polymer. The apparatus includes a measuring device (130) for measuring the amount of the deposit of the fibrin polymer on the outer wall of the container (110) and a control unit (131) for controlling the addition of solvent in response to the amount of polymer.
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28.发明授权AN APPARATUS FOR PREPARING A CONCENTRATE OF COAGULATION FACTORS, SUCH AS FIBRINOGEN, FROM A BLOOD SAMPLE 失效器具，用于产生KOAGULATIONSFAKTORKONZENTRATEN纤维蛋白原，血液样本
公开(公告)号：EP0528949B1
公开(公告)日：1996-03-06
申请号：EP91910014.9
申请日：1991-05-14
发明人： WEIS-FOGH, Ulla , HERN, Soren , HOLM, Niels, Erik
CPC分类号： A61M1/3693 , A61M1/369 , A61M2202/0449 , C07K14/75
摘要： An apparatus for preparing a concentrate of coagulation factors, such as fibrinogen, from a blood sample, comprises a first chamber (14) for collection and separation of said blood sample so as to separate a plasma fraction, and a second chamber (15) for collection of said plasma fraction through a tubing member (22, 30) and a valve (24) and for precipitation of said concentrate. The apparatus comprises furthermore a removable syringe (36) for receiving the concentrate from the second chamber (15) through a tubing member (32). The first and the second chamber (14, 15) are partially defined by the same integrally formed solid container wall (2) and comprise a common partition. The first chamber (14) is further defined by a piston (4) displaceable both in connection with the blood sample collection and the transfer of said plasma fraction to the second chamber (15) and in connection with returning said plasma fraction to the first chamber (14) upon the precipitation of the concentrate.
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29.发明公开Fibrinogen processing apparatus, method and container 失效Vorrichtung，Verfahren undBehälterzur Fibrinogenbehandlung。
公开(公告)号：EP0608121A1
公开(公告)日：1994-07-27
申请号：EP94300385.5
申请日：1994-01-19
发明人： Coelho, Philip Henry , Wolf, Terry
CPC分类号： A61J1/1412 , A61J1/10 , A61J1/1462 , A61J1/1487 , A61J2205/30 , A61M1/0272 , A61M1/0277 , A61M1/0281 , A61M2202/0449 , B01D9/0013 , C07K14/75 , A61M2202/0071
摘要： An instrumentality for promulgating the cryoprecipitation of fibrinogen from a blood product. The instrumentality contemplates a container for the blood product, an apparatus for creating the fibrinogen within the container and a method of manipulating the container within the apparatus and subsequently after fibrinogen has been formed. The apparatus includes a receiver within which the container is supported, a motion transfer device for the receiver to impart motion to the container while simultaneously subjecting the container to a temperature differential to cause heat transfer. The motion imparted to the container results in a thin coating of the blood product being disposed on an interior surface of the container which, in turn, is exposed to a heat transfer fluid through the wall of the container. Successive coatings placed on an interior of the container are timed such that each coating is placed on a previous coating that has changed phase. Flexure of the container after the contents of the container have been frozen can occur by providing a vacuum within the container causing an implosion of frozen material. Subsequent phase change back to a liquid and then a second freeze/thaw followed by centrifugation causes a cryo-fraction to be precipitated therefrom. The container within which the blood product is housed includes an opening for admission of the blood product therewithin, an outlet for extraction of fibrinogen and access to a source which can provide a pressure differential vis a vis the interior and exterior of the container. Information of the temperature profile within the container may also be provided.
摘要翻译： 从血液制品中颁布血纤维蛋白原的冷沉淀的手段。 仪器考虑了用于血液制品的容器，用于在容器内产生纤维蛋白原的装置，以及在装置内操作容器并随后在形成纤维蛋白原之后的方法。 该装置包括容器被支撑在其中的接收器，用于接收器的运动传递装置，以向容器施加运动，同时使容器经受温度差异导致热传递。 赋予容器的运动导致血液制品的薄涂层被布置在容器的内表面上，而这又暴露于通过容器壁的传热流体。 定位在容器内部的连续涂层，使得每个涂层被放置在改变阶段的先前涂层上。 在容器的内容物已被冷冻之后，容器的弯曲可以通过在容器内提供真空而导致冷冻材料的内爆而发生。 随后的相变回液体，然后第二次冷冻/解冻，然后离心导致冷冻馏分从其中沉淀。 血液制品容纳在其中的容器包括用于进入血液制品的开口，用于提取纤维蛋白原的出口和进入能够相对于容器的内部和外部提供压差的源。 还可以提供容器内的温度曲线的信息。
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30.发明公开AN APPARATUS FOR PREPARING A CONCENTRATE OF COAGULATION FACTORS, SUCH AS FIBRINOGEN, FROM A BLOOD SAMPLE 失效器具，用于产生KOAGULATIONSFAKTORKONZENTRATEN纤维蛋白原，血液样本。
公开(公告)号：EP0528949A1
公开(公告)日：1993-03-03
申请号：EP91910014.0
申请日：1991-05-14
申请人： UNES A/S
发明人： WEIS-FOGH, Ulla , HERN, Soren , HOLM, Niels, Erik
CPC分类号： A61M1/3693 , A61M1/369 , A61M2202/0449 , C07K14/75
摘要： Appareil de préparation d'un concentré de facteurs de coagulation, tel que le fibrinogène, à partir d'un échantillon de sang, qui comprend une première chambre (14) pour recueillir ledit échantillon de sang et en séparer une fraction de plasma et une deuxième chambre (15) pour recueillir ladite fraction de plasma par l'intermédiaire de tubes (22, 30) et d'un clapet (24) et pour précipiter ledit concentré. L'appareil comprend en outre une seringue amovible (36) servant à recevoir le concentré provenant de la deuxième chambre (15) par l'intermédiaire d'un tube (32). La première et la deuxième chambre (14, 15) sont partiellement définies par la même paroi de réservoir solide (2) formée d'un seul bloc et comprennent une paroi commune. La première chambre (14) est, de plus, définie par un piston (4) pouvant se déplacer à la fois pour recueillir ledit échantillon et transférer ladite fraction de plasma à la deuxième chambre (15) et également pour faire revenir ladite fraction de plasma dans la première chambre (14) lors de la précipitation du concentré.
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