公开(公告)号：EP2010477A4

公开(公告)日：2012-05-30

申请号：EP07756161

申请日：2007-04-27

Applicant: INTEZYNE TECHNOLOGIES INC

Inventor： BREITENKAMP KURT ,  SILL KEVIN N ,  SKAFF HABIB

IPC: C07C211/55 ,  C07C63/14 ,  C07D207/26 ,  C07D213/71 ,  C07D233/22 ,  C07D263/14 ,  C08G65/26 ,  C08G65/325 ,  C08G65/329 ,  C08G65/332 ,  C08G65/333 ,  C08G65/335 ,  C08G65/336 ,  C08G65/337 ,  C08G65/40

CPC classification number: C07C247/04 ,  A61K47/34 ,  C07C217/08 ,  C07C217/84 ,  C07C271/16 ,  C07D207/452 ,  C07D207/46 ,  C07D213/71 ,  C07D263/14 ,  C07D311/88 ,  C07D317/22 ,  C07D491/08 ,  C07D495/04 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/42 ,  C07F9/65502 ,  C07F9/65505 ,  C07F9/6552 ,  C08G65/2612 ,  C08G65/2627 ,  C08G65/263 ,  C08G65/325 ,  C08G65/329 ,  C08G65/3322 ,  C08G65/33303 ,  C08G65/33337 ,  C08G65/33396 ,  C08G65/3353 ,  C08G65/336 ,  C08G65/337 ,  C08G65/4006 ,  C08G2650/48 ,  C08L2203/02

公开(公告)号：EP2311899A4

公开(公告)日：2012-05-09

申请号：EP09804935

申请日：2009-08-03

Applicant: DAINIPPON INK & CHEMICALS

Inventor： OHTAGURO TSUNEYUKI ,  NOGUCHI JUN ,  YAMASHINA YOHZOH

IPC: C08G65/333 ,  C08F299/00 ,  C08F299/02 ,  C08G65/00 ,  C08G65/332 ,  C09D4/02 ,  C09D127/12 ,  C09D133/24 ,  C09D171/00

CPC classification number: C08F299/00 ,  C08F299/02 ,  C08G18/5039 ,  C08G18/8116 ,  C08G65/007 ,  C08G65/3322 ,  C08G65/33396 ,  C08G2650/48 ,  C09D171/00 ,  C09D175/16 ,  C08L75/04

公开(公告)号：EP2325188A4

公开(公告)日：2012-02-29

申请号：EP09813014

申请日：2009-08-31

Applicant: UNIMATEC CO LTD

Inventor： SAITO SATORU

IPC: C07F5/02 ,  C07B61/00

CPC classification number: C07F5/025 ,  C08G65/007 ,  C08G65/33396 ,  C08G65/337

公开(公告)号：EP2394199A1

公开(公告)日：2011-12-14

申请号：EP10739195.5

申请日：2010-02-05

Applicant: KNC NER Acquisition Sub, Inc.

Inventor： LEE, Bruce P. ,  DALSIN, Jeffrey L. ,  VOLLENWEIDER, Laura ,  MURPHY, John L. ,  XU, Fangmin

IPC: G03C1/52

CPC classification number: A61L24/043 ,  C08G65/3317 ,  C08G65/33396 ,  C08G71/04 ,  C09D5/1637 ,  C09J175/04 ,  Y10T428/2852 ,  Y10T442/10 ,  Y10T442/2738

Abstract: The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive polymer blend. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive blend constructs can be used to treat and repair, for example, hernias and damaged tendons.

公开(公告)号：EP0824126B2

公开(公告)日：2009-11-11

申请号：EP96202288.5

申请日：1996-08-14

Applicant: ENZON, INC.

Inventor： Martinez, Anthony J. ,  Greenwald, Richard B.

IPC: C08G65/32 ,  A61K47/48

CPC classification number: C08G65/338 ,  A61K47/60 ,  C08G65/329 ,  C08G65/3322 ,  C08G65/33396 ,  C08G65/337

公开(公告)号：EP2010477A2

公开(公告)日：2009-01-07

申请号：EP07756161.1

申请日：2007-04-27

Applicant: Intezyne Technologies Incorporated

Inventor： BREITENKAMP, Kurt ,  SILL, Kevin, N. ,  SKAFF, Habib

IPC: C07C211/55 ,  C07C63/14 ,  C07D207/26 ,  C07D213/71 ,  C07D263/14 ,  C07D233/22

CPC classification number: C07C247/04 ,  A61K47/34 ,  C07C217/08 ,  C07C217/84 ,  C07C271/16 ,  C07D207/452 ,  C07D207/46 ,  C07D213/71 ,  C07D263/14 ,  C07D311/88 ,  C07D317/22 ,  C07D491/08 ,  C07D495/04 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/42 ,  C07F9/65502 ,  C07F9/65505 ,  C07F9/6552 ,  C08G65/2612 ,  C08G65/2627 ,  C08G65/263 ,  C08G65/325 ,  C08G65/329 ,  C08G65/3322 ,  C08G65/33303 ,  C08G65/33337 ,  C08G65/33396 ,  C08G65/3353 ,  C08G65/336 ,  C08G65/337 ,  C08G65/4006 ,  C08G2650/48 ,  C08L2203/02

Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

公开(公告)号：EP1203784B1

公开(公告)日：2008-12-10

申请号：EP00927806.0

申请日：2000-05-18

Applicant: NOF CORPORATION

Inventor： OGURA, Atsuhiko ,  IWASAKI, Hiroshi ,  TANAKA, Shinji

IPC: C08G69/44 ,  C08G81/00 ,  C08G65/333 ,  A61L27/14 ,  A61L17/10

CPC classification number: C08G69/44 ,  A61L17/10 ,  A61L27/14 ,  A61L27/16 ,  A61L31/048 ,  C08G65/33396 ,  C08L71/02 ,  C08L53/02 ,  C08L2666/26

Abstract: A polymer having a satisfactory balance between in vivo degradability and satisfactory mechanical properties, which is an A1BA2 type polymer comprising a segment A1 and a segment A2 each having a modified amino acid and a segment B consisting of polyethylene glycol with a number-average molecular weight of 8,000 or higher bonded at one end to the segment A1 and at the other end to the segment A2, and has a number-average molecular weight of 10,000 to 600,000; an in vivo degradable material which comprises the polymer; and a film for preventing tissue adhesion, an artificial dura mater, a suture, an implant preparation, or a sustained-release drug base each comprising the degradable material.

公开(公告)号：EP1981512A1

公开(公告)日：2008-10-22

申请号：EP06721507.9

申请日：2006-05-15

Applicant: Starpharma Pty Limited

Inventor： BOYD, Benjamin James ,  KAMINSKAS, Lisa Michelle ,  PORTER, Christopher John Hamilton ,  KARELLAS, Peter ,  KRIPPNER, Guy Yeoman ,  KELLY, Brian Devlin ,  WU, Zemin ,  RAZZINO, Pasquale ,  PALLICH, Sue

IPC: A61K31/74 ,  A61K31/785 ,  A61K47/48 ,  C08G69/08 ,  C08G69/10 ,  C08G81/00

CPC classification number: C08G65/33396 ,  A61K31/74 ,  A61K31/785 ,  A61K47/59 ,  A61K47/595 ,  A61K47/60 ,  A61K47/645 ,  C08G69/10 ,  C08G83/003

Abstract: The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.

公开(公告)号：EP1718339A4

公开(公告)日：2008-08-13

申请号：EP05712158

申请日：2005-01-28

Applicant: AMBRX INC

Inventor： CHO HO SUNG ,  DANIEL THOMAS ,  HAYS ANNA-MARIA ,  WILSON TROY

IPC: C07H21/04 ,  A01N37/18 ,  A61K38/00 ,  A61K38/21 ,  A61K38/27 ,  A61K47/48 ,  C07K1/00 ,  C07K14/56 ,  C07K14/61 ,  C12N5/00 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/68 ,  G01N33/74

CPC classification number: C07H21/04 ,  A61K38/21 ,  A61K38/27 ,  A61K47/60 ,  C07K14/475 ,  C07K14/52 ,  C07K14/575 ,  C07K14/61 ,  C08G65/33396 ,  G01N33/6875 ,  G01N2500/00

公开(公告)号：EP1922350A2

公开(公告)日：2008-05-21

申请号：EP06789107.7

申请日：2006-07-31

Applicant: Nektar Therapeutics AL, Corporation

Inventor： KOZLOWSKI, Antoni ,  MCKANNAN, Jon ,  MCMANUS, Samuel, P.

IPC: C08G65/32 ,  A61K47/48

CPC classification number: C08G65/33396 ,  A61K47/60 ,  C07B47/00 ,  C08G65/329 ,  C08G65/332 ,  C08G65/48 ,  C08L71/02

Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.