公开(公告)号：EP2983682A1

公开(公告)日：2016-02-17

申请号：EP14783183.8

申请日：2014-04-11

申请人： MANGOGEN PHARMA INC.

发明人： PRAKASH, Satya ,  PAUL, Arghya ,  SHUM-TIM, Dominique

IPC分类号： A61K35/76 ,  A61K31/7088 ,  A61K38/18 ,  A61K47/34 ,  A61K9/14 ,  A61L31/08 ,  A61L31/14 ,  A61P17/02 ,  C12N11/08 ,  C12N15/866 ,  C12N7/01

CPC分类号： A61K35/76 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/19 ,  A61K38/36 ,  A61K38/363 ,  A61K48/00 ,  A61L31/10 ,  A61L31/125 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/622 ,  A61L2430/34 ,  C12N7/00 ,  C12N2710/14032 ,  C12N2710/14043 ,  C12N2710/14143

摘要： The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as supports comprising the viral microparticles for the locating the viral microparticles in a wound or in the vicinity of a wound.

摘要翻译： 本发明提供的病毒微粒，包括基因工程改造的杆状病毒（至少部分地）嵌入在用于局部递送治疗性核酸分子的脊椎动物个体的细胞中的聚合物基体（任选与医疗植入物的组合：如血管支架平台 ）。 病毒微粒的爱宣传片婷伤口愈合以及血管的修复是特别有用的，防止病理性疤痕。 所以提供了可用于制备病毒微粒过程中，药物组合物包含病毒微粒以及支撑件，其包括用于在伤口或在伤口附近的定位病毒微粒的病毒微粒。

公开(公告)号：EP2836220A4

公开(公告)日：2016-01-13

申请号：EP13775009

申请日：2013-04-10

申请人： AGENCY SCIENCE TECH & RES

发明人： WANG SHU ,  WU CHUNXIAO ,  ZHAO YING ,  LEE ESTHER XINGWEI

IPC分类号： A61K31/7088 ,  A61K35/76 ,  A61P35/00 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K31/185 ,  A61K31/7028 ,  A61K35/768 ,  A61K48/0075 ,  A61K2039/525 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/585 ,  C07K14/5443 ,  C07K14/70575 ,  C07K14/70578 ,  C12N2710/14032 ,  C12N2710/14043 ,  C12N2710/14045 ,  C12N2710/14071 ,  C12N2740/14022 ,  C12N2830/00 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2830/60 ,  A61K2300/00

摘要： There is presently provided methods and uses relating to delivering a nucleic acid molecule to a bladder cell using a baculoviral vector. The bladder cell is contacted with a baculoviral vector, which may further comprise a transgene.

摘要翻译： 目前提供了使用杆状病毒载体将核酸分子递送至膀胱细胞的方法和用途。 将膀胱细胞与杆状病毒载体接触，其可以进一步包含转基因。

公开(公告)号：EP2746394A4

公开(公告)日：2015-07-15

申请号：EP12826119

申请日：2012-08-09

申请人： OSTRICH PHARMA KK ,  IMMORTAL SPIRIT LTD

发明人： TSUKAMOTO YASUHIRO

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P17/00 ,  A61P37/08 ,  C07K16/08 ,  C07K16/12

CPC分类号： C07K16/1271 ,  C07K16/084 ,  C07K16/085 ,  C07K16/1045 ,  C07K16/1063 ,  C07K16/1267 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/76 ,  C12N2710/14043

摘要： For many diseases due to microbes or the like, proliferation of microbes themselves is a cause of a symptom. However, there were cases where a substance released by the microbes is a cause of a symptom. In such cases, when attempting to treat a disease with an antibody, it was necessary to obtain an antibody against an antigen that is a substance causing the disease. However, it was difficult to find the underlying substance causing the disease among substances released by the microbes. An antibody (polyclonal) binding to not only an antigen but also to a substance, which is secreted by the antigen and accelerates the deterioration of a symptom, is obtained by immunizing birds with a lysis solution produced from lysing microbial cells as an antigen. Further, an antibody obtained with a surface protein of a virus as an antigen is expected to inhibit an infection by a virus.

摘要翻译： 对于由微生物等引起的许多疾病，微生物本身的增殖是症状的原因。 然而，有些情况下，微生物释放的物质是症状的原因。 在这种情况下，当试图用抗体治疗疾病时，有必要获得针对导致该疾病的物质的抗原的抗体。 然而，很难找到由微生物释放的物质引起疾病的潜在物质。 通过用裂解作为抗原的微生物细胞产生的裂解液免疫鸟，获得与抗原不仅与抗原分泌并加速症状恶化的物质结合的抗体（多克隆）。 此外，预期用病毒表面蛋白获得的抗体作为抗原可以抑制病毒的感染。

公开(公告)号：EP2836220A1

公开(公告)日：2015-02-18

申请号：EP13775009.7

申请日：2013-04-10

申请人： Agency for Science, Technology and Research

发明人： WANG, Shu ,  WU, Chunxiao ,  ZHAO, Ying ,  LEE, Esther, Xingwei

IPC分类号： A61K31/7088 ,  A61K35/76 ,  A61P35/00 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K31/185 ,  A61K31/7028 ,  A61K35/768 ,  A61K48/0075 ,  A61K2039/525 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/585 ,  C07K14/5443 ,  C07K14/70575 ,  C07K14/70578 ,  C12N2710/14032 ,  C12N2710/14043 ,  C12N2710/14045 ,  C12N2710/14071 ,  C12N2740/14022 ,  C12N2830/00 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2830/60 ,  A61K2300/00

摘要： There is presently provided methods and uses relating to delivering a nucleic acid molecule to a bladder cell using a baculoviral vector. The bladder cell is contacted with a baculoviral vector, which may further comprise a transgene.

公开(公告)号：EP2530162A1

公开(公告)日：2012-12-05

申请号：EP11187828.6

申请日：2006-05-05

申请人： Temasek Life Sciences Laboratory Limited

发明人： Kwang, Jimmy ,  Lu, Li Qun

IPC分类号： C12N15/866 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K39/145 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/14043 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2810/6072 ,  C12N2810/6081

摘要： A vaccine for the treatment or prevention of a disease in a subject, wherein said disease is associated with an avian influenza virus, and wherein said vaccine comprises an expression vector comprising a nucleic acid encoding a hemagglutinin peptide, such that in use said hemagglutinin peptide is expressed by said expression vector in said subject.

摘要翻译： 一种用于治疗或预防受试者疾病的疫苗，其中所述疾病与禽流感病毒相关，并且其中所述疫苗包含含有编码血凝素肽的核酸的表达载体，使得在使用中所述血凝素肽是 由所述受试者中的所述表达载体表达。

公开(公告)号：EP2481421A1

公开(公告)日：2012-08-01

申请号：EP12165993.2

申请日：2008-02-11

申请人： Boehringer Ingelheim Vetmedica, Inc.

发明人： Fachinger, Vicky ,  Elbers, Knut ,  Kixmoeller, Marion ,  Orveillon, Francois-Xavier ,  Frein von Richthofen, Isabelle ,  Lischewski, Axel

IPC分类号： A61K39/12 ,  C07K14/01

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N7/00 ,  C12N2710/14041 ,  C12N2710/14043 ,  C12N2710/14143 ,  C12N2750/10034 ,  C12N2750/10071

摘要： The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.

摘要翻译： 本发明涉及包含猪圆环病毒2型（PCV2）抗原的免疫原性组合物在动物，优选猪中预防和治疗亚临床PCV2感染的用途。

公开(公告)号：EP2424980A1

公开(公告)日：2012-03-07

申请号：EP10721379.5

申请日：2010-04-30

申请人： Redbiotec AG

发明人： JOHN, Corinne ,  SCHAUB, Christian ,  WELLNITZ, Sabine

IPC分类号： C12N7/04

CPC分类号： C12N15/86 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2710/14143 ,  C12N2710/16123 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2760/16023 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The invention describes novel virus-like particles for use as vaccines, diagnostic tools and R&D tools based on recombinant DNA and cell cultivation techniques for production. The recombinant virus-like particles of the invention are assembled by polypeptide chains that incorporate several, in particular two or more, different epitopes which are selected either (a) from different viral strains of the same virus and/or (b) from different serotypes of the same virus and/or (c) from different viral strains specific for different hosts. These epitopes are then displayed on the particle surface.

公开(公告)号：EP2185711A4

公开(公告)日：2011-01-19

申请号：EP08797373

申请日：2008-08-07

申请人： UNIV WAYNE STATE

发明人： CARLOCK LEON ,  CYPHER MARIA

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： C12N15/85 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0393 ,  A61K48/00 ,  A61K48/0066 ,  C07K14/4713 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/14043 ,  C12N2750/14143 ,  C12N2799/025 ,  C12N2799/026 ,  C12N2830/42 ,  C12N2840/00 ,  C12N2840/10 ,  C12N2840/203 ,  C12N2840/44 ,  C12N2840/85 ,  G01N33/5014 ,  G01N2333/90241 ,  G01N2510/00

公开(公告)号：EP1941903A1

公开(公告)日：2008-07-09

申请号：EP07100054.1

申请日：2007-01-03

申请人： Boehringer Ingelheim Vetmedica GmbH

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61K39/12 ,  C07K14/01 ,  C12N15/866

CPC分类号： A61K39/12 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55555 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2750/10022 ,  C12N2750/10034

摘要： The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of porcine respiratory disease complex (PRDC) in animals, preferably in pigs.

摘要翻译： 本发明涉及包含猪圆环病毒2型（PCV2）抗原的免疫原性组合物在动物，优选猪中用于预防和治疗猪呼吸道疾病复合物（PRDC）的用途。

公开(公告)号：EP1904098A2

公开(公告)日：2008-04-02

申请号：EP06769511.4

申请日：2006-07-06

申请人： Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy Wpulawach ,  Uniwersytet Gdanski

发明人： FITZNER, Andrzej ,  KESY, Andrzej ,  SZEWCZYK, Boguslaw ,  GROMADZKA, Beata

IPC分类号： A61K39/125

CPC分类号： A61K39/125 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K14/005 ,  C12N2710/14043 ,  C12N2770/16022 ,  C12N2770/16023 ,  C12N2770/16034

摘要： The subject of the present invention is a method of manufacturing a recombinant vaccine against rabbit viral haemorrhagic disease, the vaccine and the application of a recombinant protein antigen in the manufacture of the vaccine. The subjects of the present invention facilitate the production of a recombinant capsid protein exhibiting hemagglutinin and antigenic properties, which is able to form virus-like particles (VLP) and to stimulate the production of specific antibodies in inoculated animals.